Tetra-μ-benzoato-bis­[(3-methyl­quinoline)copper(II)](Cu—Cu)

In the title compound, [Cu2(C7H5O2)4(C10H9N)2], the paddle-wheel-type dinuclear complex mol­ecule contains four bridging benzoate groups and two terminal 3-methyl­quinoline ligands. The asymmetric unit contains one and a half mol­ecules with a total of three independent Cu atoms; there is an inversion center at the mid-point of the Cu⋯Cu bond in one molecule. The octa­hedral coordination of each Cu atom, with four O atoms in the equatorial plane, is completed by an N atom of a 3-methyl­quinoline ligand [Cu—N = 2.190 (4)–2.203 (3) Å] and by another Cu atom [Cu⋯Cu = 2.667 (1) and 2.6703 (7) Å]. The Cu atoms are all ca 0.22 Å out of the plane of the four bonded O atoms

N,N,N′,N′-Tetra­kis(2-hy­droxy-5-methyl­benz­yl)ethane-1,2-diamine dimethyl­formamide disolvate

The title compound, C34H40N2O4·2C3H7NO, was synthesized by the Mannich condensation of ethane­diamine, formaldehyde and p-cresol. In the crystal, the tetra­phenol mol­ecule is arranged around an inversion center. The mol­ecule and the dimethyl­formamide solvate are linked through an O—H⋯O hydrogen bond. An intra­molecular O—H⋯N hydrogen bond occurs in the tetra­phenol mol­ecule, which may influence the mol­ecular confomation. Futhermore, C—H⋯O and π–π stacking inter­actions [centroid–centroid distance = 3.7081 (14) Å] stabilize the crystal packing, building a three-dimensional network

Homoleptic [ONO]2Ti(IV) type complexes of amino-acid-tethered phenolato, Schiff-base ligands: Synthesis, characterization, time-resolved fluorescence spectroscopy, and cytotoxicity against ovarian and colon cancer cells

Six homoleptic Ti(IV) compounds of dianionic tridentate Schiff base ligands were synthesized from chiral amino acids, 2-hydroxybenzaldehyde and Ti(OiPr)4. The compounds were spectroscopically characterized and the molecular geometries were established by X-ray crystallography. The ligands coordinated the titanium via carboxylate-O-, imine-N-, and phenoxide-O atoms. Two isomers were identified; each based on a trans-N2O4 donor set, but one with trans carboxylate-O atoms and another with each carboxylate-O atom trans to a phenoxide-O atom. Photophysical profiles exhibited faster excited-state relaxation in the solid phase than in solution. Marked cytotoxicities were recorded toward human ovarian A2780 and colon HT-29 cancer cells with IC50 values ranging between 23±2 and 103±3 µM. Comparative hydrolytic stability studies by NMR in 10% D2O solutions provided t1/2 values of up to 15±2 h, with little correlation to cytotoxicity implying a role of hydrolysis products in the reactivity and identifying steric bulk as a contributor to stability and solubility

Dibenzoatobis[3-(pyrrol-1-ylmeth­yl)pyridine]­zinc(II)

In the title compound, [Zn(C7H5O2)2(C10H10N2)2], the ZnII ion, located on a twofold axis, is coordinated by two N atoms from two 3-(pyrrol-1-ylmeth­yl)pyridine ligands and two O atoms from two benzoate ligands in a distorted tetra­hedral geometry. The pyridine and the pyrrole rings are nearly perpendicular to each other, making a dihedral angle of 84.83 (7)°

Asymmetric pentafulvene carbometalation-access to enantiopure titanocene dichlorides of biological relevance

Unprecedented asymmetric copper-catalyzed addition of ZnEt2 (ZnBu2) to the exocyclic C[DOUBLE BOND]C bond of pentafulvenes C5H4([DOUBLE BOND]CHAr) (Ar=2-MeOPh and related species) results in enantiomerically enriched (up to 93:7 e.r.) cyclopentadienyl ligands (C5H4CHEtAr; abbreviated CpR). Copper catalyst promotion with both chiral phosphoramidite ligands and a phosphate additive is vital in realizing both acceptable enantioselectivities and reaction rates. Enantiomeric CpR2TiCl2 complexes have been prepared; the (S,S) isomer is twice as active towards pancreatic, breast, and colon cancer cell lines as its (R,R) enantiomer at 24 h

3,5-Diamino-4H-1,2,4-triazol-1-ium (6-carb­oxy­pyridine-2-carboxyl­ato)(pyridine-2,6-dicarboxyl­ato)cuprate(II) trihydrate

In the complex anion of the title compound, (C2H6N5)[Cu(C7H4NO4)(C7H3NO4)]·3H2O, the CuII atom is coordinated by tridentate 6-carb­oxy­pyridine-2-carboxyl­ate and pyridine-2,6-dicarboxyl­ate ligands and is surrounded by four O atoms in the equatorial plane and two N atoms in axial positions in a distorted octa­hedral geometry. In the crystal, the components are linked into a three dimensional network by O—H⋯O, N—H⋯O, N—H⋯N and C—H⋯O hydrogen bonds and a π–π inter­action with a centroid–centroid distance of 3.6080 (8) Å

Bis(methanol-κO)bis­(quinoline-2-carboxyl­ato-κ2 N,O)nickel(II)

In the title complex, [Ni(C10H6NO2)2(CH3OH)2], the NiII ion lies on an inversion center and is coordinated by two quinoline-2-carboxyl­ate ligands in the equatorial sites and two axial methanol ligands, forming a distorted octa­hedral environment. In the crystal, mol­ecules are linked via O—H⋯O hydrogen bonds into a two-dimensional network parallel to (10)

Bis(di-2-pyridyl­methane­diol-κ3 N,O,N′)nickel(II) dibenzoate

The title compound, [Ni(C11H10N2O2)2](C7H5O2)2, consists of an NiII ion coordinated by two tridentate chelating (2-py)2C(OH)2 ligands (py is pyrid­yl) and two benzoate anions. The NiII ion is located on a twofold rotation axis, and its geometry is distorted octa­hedral. The gem-diol ligand (2-py)2C(OH)2 adopts an η1:η1:η1 coordination mode. There are O—H⋯O hydrogen bonds between the gem-diol ligands and benzoate anions

Tetra-μ-benzoato-bis­{[4-(pyrrolidin-1-yl)pyridine]zinc(II)}

The central part of the title centrosymmetric dinuclear complex, [Zn2(C7H5O2)4(C9H12N2)2], has a paddle-wheel conformation with four benzoate ligands bridging two symmetry-related ZnII ions. The distorted square-pyramidal coordination environment around the ZnII ion is completed by an N atom from a 4-(pyrrolidin-1-yl)pyridine ligand. The Zn⋯Zn separation of 2.9826 (12) Å does not represent a formal direct metal–metal bond. The ZnII ion is displaced by 0.381 (1) Å from the mean plane of the four basal O atoms. Two of the C atoms of the pyrrolidine ring are disordered over two sites with refined occupancies of 0.53 (2) and 0.47 (2)