Frequency permutation arrays

Motivated by recent interest in permutation arrays, we introduce and investigate the more general concept of frequency permutation arrays (FPAs). An FPA of length n=m lambda and distance d is a set T of multipermutations on a multiset of m symbols, each repeated with frequency lambda, such that the Hamming distance between any distinct x,y in T is at least d. Such arrays have potential applications in powerline communication. In this paper, we establish basic properties of FPAs, and provide direct constructions for FPAs using a range of combinatorial objects, including polynomials over finite fields, combinatorial designs, and codes. We also provide recursive constructions, and give bounds for the maximum size of such arrays.Comment: To appear in Journal of Combinatorial Design

A Swedish comment on ‘review: the availability of life-cycle studies in Sweden’

The article entitled ‘Review: the availability of life-cycle studies in Sweden’ by Croft and colleagues (January 2019, volume 24, issue 1, pages 6–11) has puzzled many researchers in Sweden. The stated purpose of the article is to review the availability of water and carbon footprinting studies and life-cycle assessment (LCA) studies in Sweden. Despite its title and purpose suggesting otherwise, the article appears to be about the accessibility of life-cycle case studies from Sweden in South Africa. It is problematic that the article claims to be a review in the title and text, but is presented by the journal as a commentary. We believe that the article’s method is unclear and that its title and results are misleading. The authors of the article found only 12 academic papers, 10 academic theses, 8 company reports, and 1 presentation. This result significantly underestimates the actual production and availability of Swedish LCA case studies

Technical, Economic, and Environmental Assessment of Wastewater and Sludge Management Solutions Designed to Overcome Common Issues

In order to support decision-making in design of wastewater and sludge management within the European Union, the EU FP7 project ROUTES has performed technical development aimed at sludge minimisation, the enabling of agricultural use of sludge and sludge resource recovery. Technical, economic and environmental assessment has been performed for ten case studies in which model (non-existent) reference plants of different size and configuration, representative of real wastewater treatment plants in Europe, have been considered to be upgraded to solve different common problems, based on the new knowledge from the technology development carried out within the project. This paper reports on the methodology used in the assessment with examples of obtained results for three of the case studies. The methodology in particular highlights some critical points that need further attention when similar upgrading is considered in real cases

Upgrading a wastewater treatment plant with thermophilic digestion of thermally pre-treated secondary sludge: techno-economic and environmental assessment

Nowadays, several technologies and management strategies are proposed for upgrading wastewater treatment plants (WWTPs) in order to improve sludge stabilization or minimize sludge production. In order to make sure that this leads to overall improvements, their techno-economic and environmental performance has to be carefully evaluated. In response to this, the techno-economic and environmental performance was assessed for a considered model reference WWTP upgraded with separate treatment and disposal for primary and secondary sludge to provide guidance to research, policy and investment efforts. This paper departs in an experimental campaign carried out within the EU project "ROUTES" and describes an assessment of an upgrade of a WWTP, involving wet oxidation of primary sludge and thermophilic anaerobic digestion (integrated with thermal hydrolysis pre-treatment) for secondary sludge. The reference plant and the upgrade implied different disposal routes for the resulting sludges: incineration for the stabilized sludge deriving from the reference WWTP; agricultural land application for the secondary stabilized sludge from the upgraded plant and landfilling for the solid residue deriving from the wet oxidation process (as non-hazardous waste). The mass balance carried out for both reference and upgraded WWTPs showed a reduction of total sludge production (up to 45%) for the upgraded WWTP. The additional energy demand of the upgraded solution (+22.4 Wh/(PE d), PE: population equivalent) was partially balanced by the electric energy produced by combined heat and power unit installed in the upgraded WWTP (-18.08 Wh/(PE d)). The integrated assessment showed that the upgraded solution, although resulting in an increase of WWTP technical complexity, may contribute to environmental and economic advantages. The paper provides guidance in terms of which aspects need a more thorough evaluation when this upgrade is considered in real cases

Upgrading small wastewater treatment plants with the sequencing batch biofilter granular reactor technology: Techno-economic and environmental assessment

7sinonenoneDi Iaconi, Claudio; Del Moro, Guido; Bertanza, Giorgio; Canato, Matteo; Laera, Giuseppe; Heimersson, Sara; Svanström, MagdalenaDi Iaconi, Claudio; Del Moro, Guido; Bertanza, Giorgio; Canato, Matteo; Laera, Giuseppe; Heimersson, Sara; Svanström, Magdalen

Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort.

Recent genome-wide association studies have identified 1q31 (RGS1), 2q11-12 (IL18RAP), 3p21 (CCR1/CCR3/CCR2), 3q25-26 (IL12A/SCHIP1), 3q28 (LPP), 4q27 (IL2/IL21), 6q25 (TAGAP) and 12q24 (SH2B3) as susceptibility regions for coeliac disease (CD). We have earlier replicated association with the IL2/IL21 region. This study aimed at replicating the remaining regions in a family cohort using the transmission disequilibrium test, which is not prone to population stratification as a source of false-positive results. Nine single nucleotide polymorphisms (SNPs) within these regions were genotyped in 325 Swedish-Norwegian CD families. We found significant associations with the same alleles in the regions 1q31 (rs2816316; P(nc)=0.0060), 3p21 (rs6441961; P(nc)=0.0006), 3q25-26 (rs17810564; P(nc)=0.0316 and rs9811792; P(nc)=0.0434) and 3q28 (rs1464510; P(nc)=0.0037). Borderline, but non-significant, associations were found for rs917997 (IL18RAP), whereas no evidence for association could be obtained for rs13015714 (IL18RAP) or rs1738074 (TAGAP). The lack of replication of the latter SNPs could be because of limited power. rs3184504 (SH2B3) was not analysed because of assay failure. The most significantly associated region, 3p21 (CCR1/CCR3/CCR2), was further analysed by typing of 30 SNPs, with the aim of identifying the causal variant responsible for the initial association. Several SNPs showed association with CD, but none displayed associations stronger than rs6441961, nor did any of them add to the effect initially marked by rs6441961 in a conditional analysis. However, differential effects of rs6441961(*)C carrying haplotypes were indicated, and we thus cannot exclude the possibility that our inability to obtain evidence for multiple independent effects in the CCR1/CCR3/CCR2 gene region was related to a power issue

Fine mapping study in Scandinavian families suggests association between coeliac disease and haplotypes in chromosome region 5q32.

The previous genome-wide scan in Scandinavian families supported earlier evidence for linkage of a region on chromosome 5 (5q31–33) to coeliac disease. This study deals with further genetic mapping of an 18 cM region, spanning from marker GAh18A (131.87 Mb) to D5S640 (149.96 Mb). Linkage and association analyses were performed in a two-step approach. First, seven microsatellites were added. Strong evidence for linkage was obtained with a Zlr score of 3.96, Pnc = 4 7 10−5 at marker D5S436. The strongest association was with a haplotype consisting of the markers D5S2033 and D5S2490 (Pn