Asymptotically Safe Quantum Field Theories in Perturbative Regime and Beyond

The range of topics covered in this thesis reflects the extent to which the tree of Asymptotic Safety research has branched out in recent years. The thesis consists of two parts, one dealing with pure particle models and one adding gravity to the mix. Having roots in a 1996 paper by Reuter, Asymptotic Safety was for a long time thought of as \u201conly\u201d a promising approach to quantum gravity. In 2014 an impor- tant new branch was grafted to the tree when Litim and Sannino discovered first examples of asymptotically safe quantum field theories structurally similar to the Standard Model. In the first part of the thesis we work in perturbation theory and with instanton calculus to extend the work of Litim and Sannino. The extension goes in two directions. A more formal one studies the instanton effects in their model. The other, more pragmatic one, seeks asymptotically safe minimal extensions of the Standard Model. Despite being historically first, asymptotic safety in quantum grav- ity context is studied after pure particle models here. The reasons are that quantum gravity is a logical extension of \u201cbeyond the Standard Model\u201d particle physics, and that it relies heavily on the less-known functional renormalization group. We will show that a generic matter-gravity fixed point of the renormalization group flow al- ways contains gravity-induced non-minimal matter-gravity interactions. This com- putation will also demonstrate the practical necessity of dealing with background independence in Asymptotic Safety, which is the final topic that we address

Adoption of Business Process Orientation Practices: Slovenian and Croatian Survey

Process orientation has been empirically linked to corporate performance. Several studies have shown that more process oriented companies perform better than less process oriented companies. Consequently, many researchers attempted to define what makes a company process oriented, which resulted in numerous frameworks and conceptualizations of process orientation. Based on concepts of business process orientation (BPO) the authors have developed and operationalised a concept of extended BPO to study its adoption in two countries, one EU member and one a candidate for EU membership (Slovenia and Croatia, respectively). Extensive field study has been carried out in these countries. The results of the analysis show that there are many statistically significant differences, namely companies in Slovenia have implemented process oriented practices to a higher degree than their counterparts in Croatia. The paper shows the main differences in BPO areas and practices.business process orientation, process orientation, maturity, empirical research, Croatia, Slovenia

Safe and free instantons

We investigate the instanton dynamics of asymptotically safe and free quantum field theories featuring respectively controllable ultraviolet and infrared fixed points. We start by briefly reviewing the salient points about the instanton calculus for pure Yang Mills (YM) and QCD. We then move on to determine the role of instantons within the controllable regime of the QCD conformal window. In this region we add a fermion-mass operator and determine the density of instantons per unit volume as function of the fermion mass. Finally, for the first time, we extend the instanton calculus to asymptotically safe theories.Comment: 34 pages, 15 figure

Image guided constitutive modeling of the brain tissue

Issued as final reportUnited States. Department of Health and Human Service

Mechanics and Computational Modeling of Pharmaceutical Tabletting Process

Reference Module in Materials Science and Materials EngineeringPharmaceutical Manufacturing Technology Centre (PMTC) in Irelan

Quantum fields without wick rotation

We discuss the calculation of one-loop effective actions in Lorentzian spacetimes, based on a very simple application of the method of steepest descent to the integral over the field. We show that for static spacetimes this procedure agrees with the analytic continuation of Euclidean calculations. We also discuss how to calculate the effective action by integrating a renormalization group equation. We show that the result is independent of arbitrary choices in the definition of the coarse-graining and we see again that the Lorentzian and Euclidean calculations agree. When applied to quantum gravity on static backgrounds, our procedure is equivalent to analytically continuing time and the integral over the conformal factor

Evaluation of pretreatment serum interleukin-6 and tumour necrosis factor alpha as a potential biomarker for recurrence in patients with oral squamous cell carcinoma

Background: Oral squamous cell carcinoma (OSCC) constitutes 3 percent of all cancers with predominant occurrence in middle aged and elderly males. Tumour recurrence worsens disease prognosis and decreases quality of life in patients with OSCC. Proinflammatory cytokines such as interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α) have been suggested to play a certain role in variety of tumours. The aim of this study was to investigate the relationship of pretreatment serum IL-6 and TNF-α levels on tumour recurrence in patients with OSCC in order to identify potential biomarkers for the early detection of disease recurrence. Material and Methods: The patients with newly diagnosed OSCC were treated and followed from the first visit from November 2006 until January 2008. Serum IL-6 and TNF-α concentrations were measured. The records of the patients were re-examined in July 2012 and data were recorded about cancer characteristics and tumour recurrence. Disease free survival was analyzed by Kaplan-Meier survival curves, log rank test and Cox proportional hazards regression. Results: Serum IL-6 was shown as an independent risk factor for tumour recurrence. Conclusions: Pretreatment serum IL-6 concentration may be a useful biomarker for identification of OSCC patients with increased risk of the disease recurrence

In search of a UV completion of the standard model \u2014 378,000 models that don\u2019t work

Asymptotically safe extensions of the Standard Model have been searched for by adding vector-like fermions charged under the Standard Model gauge group and having Yukawa-like interactions with new scalar fields. Here we study the corresponding renormalization group \u3b2-functions to next and next-to-next to leading order in the perturbative expansion, varying the number of extra fermions and the representations they carry. We test the fixed points of the \u3b2-functions against various criteria of perturbativity to single out those that are potentially viable. We show that all the candidate ultraviolet fixed points are unphysical for these models: either they are unstable under radiative corrections, or they cannot be matched to the Standard Model at low energies

Assessment of intra- and inter-ventricular cardiac dyssynchrony in patients with repaired Tetralogy of Fallot: a cardiac magnetic resonance study

Background Patients with repaired tetralogy of Fallot (TOF) frequently have right bundle branch block. However, the contribution of cardiac dyssynchrony to dysfunction remains controversial. To better understand this phenomenon and ultimately study therapies, we developed a method to quantify left (LV), right (RV) and inter-ventricular cardiac dyssynchrony using standard cine CMR. Methods 30 patients with repaired TOF (age 28 ± 16, 46% female) and 17 healthy controls (age 29 ± 7, 12% female) underwent cine CMR. Patients were imaged twice to assess inter-test reproducibility. Circumferential strain vs time curves were generated with a custom feature tracking algorithm for 12 LV and 12 RV segments in 4-7 slices encompassing the ventricles. For each segment, the temporal offset (TO) of the strain curve relative to a global reference curve derived from the controls was calculated and expressed as a percent of the cardiac cycle. The intra-ventricular dyssynchrony index (DI) for each ventricle was computed as the standard deviation (SD) of the TOs (more dyssynchrony increases the SD). The inter-ventricular DI was calculated as the difference in median RV and median LV TOs. Regional dyssynchrony was quantified in 3 LV (septum, infero-lateral and antero-lateral wall) and 3 RV (septum, sinus, outflow tract) regions using median TOs. Results Compared to controls, patients with repaired TOF had a greater LV, RV and inter-ventricular DI. The greater inter-ventricular delay in the patients was primarily due to a global delay in RV contraction with the RV contracting 4.9 ± 3.5% later than the LV in patients vs 1.4 ± 3.2% earlier in controls. Median TOs were similar in the three LV regions between patients and controls, but all three RV regions were significantly delayed in patients compared to the controls. Contraction patterns in the RV were also distinct: in controls, the earliest contraction was seen in the outflow tract; in patients, contraction occurred first in the septum and last in the outflow tract. Inter-test reproducibility for the three DIs was good with all coefficients of variation Conclusions Patients with repaired TOF suffer from left, right and inter-ventricular cardiac dyssynchrony which can all be quantified from standard cine CMR with good inter-test reproducibility. Future studies need to determine whether these patients may benefit from resynchronization therapy