Virtual Environment as a Design Tool for Sustainable Residential Spaces in Light of Theory of Planned Behavior

This study aims to reveal the impact of Virtual Environment as a design tool on the interior architect's design behavior towards adopting sustainable residential interior design practices. This approach is guided by the Theory of Planned Behaviour as a theoretical framework; the purpose as such would serve to bridge the gap between theoretical knowledge and its practical implementation to promote sustainable design practices. Findings revealed that Virtual Environment is anticipated to assist the interior architect in integrating the complex sustainable residential design objectives, and thus positively affect the interior architect's behavioral performance towards embracing sustainable residential design solutions.© 2016. The Authors. Published for AMER ABRA by e-International Publishing House, Ltd., UK. Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies, Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.Keywords: Virtual Environment; Residential Spaces; Sustainable Design; Theory of Planned Behavior

Phenotypic variability in patients with isodicentric Y(p11.3). a clinical, cytogenetic and molecular study

Introduction: Isodicentric (idic) chromosomes are the most common Y structural abnormalities and their influence on gonadal and somatic development is extremely variable. The prediction of their phenotypic consequences is often difficult because of the variety of genomic sequences concerned by duplications and deletions, and the variable degrees of mosaicism, 45, X cell line in particular, in various tissues. The Aim: This study was conducted to provide more information on patients with idic (Yq) allowing a better phenotype-karyotype correlation and understanding the sexual differentiation in these patients . Patients and Methods: The study included 14 patients referred to the out patient clinic of the Human Genetics Department, Medical Research Institute,University of Alexandria. The reason for referral was genital ambiguity [8 patients], short stature with variable Turner stigmata [4 patients] and primary amenorrhea with normal height [2 patients]. All patients were subjected to clinical examination and chromosome analysis by GTG and CTG-banding techniques. Fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR)were done to determine the structure of the marker chromosomes detected by conventional methods. Results: Chromosome analysis revealed a 45, X/46, X,idic (Y) (p11.3) in ten patients with variable degree of mosaicism, non mosaic 46, X, idic (Y) (p11.3) in two patients and a predominant 46, XX cell line along with 47, XX, idic (Y) (p11.3) cell line in two other patients .While the patients with an idic (Yq) described in this report were phenotypically different, all are considered as being at increased risk for gonadoblastoma. The great phenotypic variations seen in patients with an isodicentric Y chromosome greatly limit the genotype – phenotype correlation. Keywords: Isodicentric Y, mosaicism, FISH, SRY, phenotype genotype correlationEgyptian Journal of Medical Human Genetics Vol. 9 (2) 2008: pp. 189-20

Changes in left atrial deformation in hypertrophic cardiomyopathy: Evaluation by vector velocity imaging.

OBJECTIVES: Hypertrophic cardiomyopathy (HCM) represents a generalized myopathic process affecting both ventricular and atrial myocardium. We assessed the global and regional left atrial (LA) function and its relation to left ventricular (LV) mechanics and clinical status in patients with HCM using Vector Velocity Imaging (VVI). METHODS: VVI of the LA and LV was acquired from apical four- and two-chamber views of 108 HCM patients (age 40 ± 19years, 56.5% men) and 33 healthy subjects, all had normal LV systolic function. The LA subendocardium was traced to obtain atrial volumes, ejection fraction, velocities, and strain (ϵ)/strain rate (SR) measurements. RESULTS: Left atrial reservoir (ϵsys,SRsys) and conduit (early diastolic SRe) function were significantly reduced in HCM compared to controls (P  - 1.8s(- 1) was 81% sensitive and 30% specific, SRa> - 1.5s(- 1) was 73% sensitive and 40% specific. By multivariate analysis global LVϵsys and LV septal thickness are independent predictors for LAϵsys, while end systolic diameter is the only independent predictor for SRsys, P < .001. CONCLUSION: Left atrial reservoir and conduit function as measured by VVI were significantly impaired while contractile function was preserved among HCM patients. Left atrial deformation was greatly influenced by LV mechanics and correlated to severity of phenotype

HUBUNGAN PENGETAHUAN IBU TENTANG IMUNISASI PENTABIO DENGAN KETETAPAN PEMBERIAN IMUNISASI PENTABIO PADA BAYI USIA 2-11 BULAN DI BIDAN PRAKTEK MANDIRI MARTAPURA TAHUN 2017

Pengetahuan ibu mengenai imunisasi sangat berpengaruh terhadap ketepatan jadwal pemberian imunisasi. Ketidaktepatan waktu atau jadwal pemberian imunisasi menyebabkan vaksin tidak bekerja secara optimal.Sampel dalam penelitian ini adalah semua ibu yang mempunyai bayi usia 2-11 bulan yang berkunjung ke BPM di Martapura yang memenuhi syarat inklusi dan ekslusi dengan teknik total sampling.Jumlah sampel yang didapatkan adalah 42 responden. Pengambilan data dilakukan dengan menggunakan kuisioner dan check list. Data yang telah terkumpul kemudian dianalisis menggunakan uji statistik Chi Square (X2).Hasil penelitian yang didapat adalah pengetahuan ibu tentang imunisasi rendah menyebabkan ketepatan imunisasi Pentabio Kombinasi juga rendah. Hasil uji statistik menunjukkan bahwa nilai Chi-Square yaitu 9,227 lebih besar dibandingkan dengan nilai tabel 3,841 (Xhitung 9,227 &gt; Xtabel 3,841) dan P Value = 0,001, dimana Sig &lt; nilai α (0,001 &lt; 0,05). Berdasarkan hasil penelitian sebagian besar ibu memiliki pengetahuan yang kurang tentang imunisasi sehingga ketepatan imunisasi DPT pun rendah

Interplay between matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in acute asthma exacerbation and airway remodeling

AbstractBackgroundAirway inflammation and remodeling of extracellular matrix are important features of asthma. Matrix metalloproteinases (MMPs) are group of enzymes expressed in the airways with their inhibitor (tissue inhibitor of MMPs (TIMP) and they are the key responsible for extra cellular matrix (ECM) degradation.ObjectiveTo clarify the role of MMP-9 and TIMP-1 in asthma exacerbation and airway remodeling.Subjects and methodsThe study included 3 groups, group “A” included 22 patients with stable asthma group “B” included 18 patients during asthma exacerbation and group “C” of 18 healthy volunteer served as control. All groups were matching age and sex. Levels of MMP-9 and TIMP-1 were measured in the induced sputum of the 3 groups. Serum IgE skin prick test and PEFR were assessed.ResultsMMP-9, TIMP-1 and MMP-9/TIMP-1 ratio increased in both A and B groups in comparison to control (P<0.001). During exacerbation MMP-9 and MMP-9/TIMP-1 ratio showed significant increase for both but TIMP-1 did not show significant change when compared to stable asthmatics. There was significant negative correlation between PEFR and MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio.ConclusionMMP-9 and TIMP-1 play an important role in pathophysiology of asthma exacerbation and airway remodeling. Clearly, a greater understanding of the pathogenesis of asthma is critical to the development of better therapeutic modalities

Development and Evaluation of Elisa Kits Based on Proteomics Technology for Detection and Semi-Quantification of Meat Species Adulteration

Purpose: This study aimed to develop ELISA kits for the detection of meat species adulteration in raw and processed meat and evaluate its specificity and sensitivity. Method: We identify the unique peptide markers based on the proteomics approach. Subsequently, we prepared specific antisera for beef, pork, horse, sheep, chicken and developed ELISA kits. Results: Evaluation of the developed kits in testing crooked reference sample mixtures revealed that the developed  ELISA kits showed 100% specificity with no cross-reactivity detected for the non-target species. In terms of sensitivity, the developed ELISA kits were able to consistently detect pork in the sample mixtures and horses at levels down to 5% w/w. Although sheep and chicken were detected at levels as low as 1% w/w. The beef-specific ELISA test showed greater sensitivity.   Conclusions: It is concluded that the developed ELISA kits are a promising tool but further studies are still required for validation of the developed kits and comparing its results with the commercially used kits before entry into the production phase