1,864 research outputs found

    Imagine being asked to evaluate your CEO …: Using the constructive controversy approach to teach gender and management in times of economic crisis

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    This article addresses the relationship between gender and management as intertwined discursive practices. Following a constructive controversial approach, we proposed to the students to complete a short story in which they have to give a feedback either to a fictitious female or to a male boss. The article has a dual aim since it offers a reflection on a teaching methodology suited to foster critical thinking in the classroom and analyzes the narratives so produced in search of what constitutes the students’ idea of “good management.” In positioning men/women CEO within a narrative, students enact a moral order that evaluates management in society. Their narratives reveal how the economic crisis has undermined the positive image of the male manager, while femaleness is emphasized for its anti-managerial imaginary. Moreover, the idea of what constitutes “good management” is constructed around an idea of care for both male and female CEOs

    Staging precariousness: The Serpica Naro catwalk during the Milan Fashion Week

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    The article illustrates the Italian process of work precarisation and the collective resistance of precarious workers. It interprets them in terms of the birth of a collective identity that conducts a critique against precariousness while developing learning resources. Through discursive analysis of the Serpica Naro catwalk, organised in the area of Milan by the activists of the May Day Parade and the San Precario network, the article illustrates the process of construction of this collective identity that uses irony and playfulness to resist and denounce precarious working conditions. The purpose is to interpret the anti-precariousness movement as a process of critical urban learning that creates the viability of spaces for resistance in metropolitan contexts

    What makes a “good manager”? Positioning gender and management in students’ narratives

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    The purpose of this paper is to address the relationships between gender and management in the narratives of students. More specifically, the authors discuss how the discourse on management is mobilized as a discursive practice able to make some form of that activity thinkable and practicable: who can be a CEO? What kind of managerial competencies are attributed to men/women CEOs? What kind of moral order is expressed in the stories told? Design/methodology/approach – Stimulus texts have been used to elicit narratives. Students were asked to complete a short story regarding a fictive managerial character, either female or male, whose performance and attitude they were asked to evaluate. Findings – The paper discusses how the collected stories as a whole expressed a conception of what counts as a “good manager” and how management is gendered. In the analysis, the authors discuss whether and how the relationships between gender and management are changing, or the basic assumptions about “think manager-think male” are still valid. The paper illustrates a traditional positioning of gendered management along the lines of rationality vs care, and a third positioning in which the ideal of the “good manager” has both competencies. Originality/value – The authors designed an alternative research strategy focused on how gender and management are discursively constructed within a context of economic crisis that affects management reputation. Particularly, the authors discuss the surprising results concerning how the written stories evaluating male CEOs distrusted the masculine way of managing and positioned the female managing style within a trustworthy context

    Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: Functional and therapeutic implications

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    This article is made available through the Brunel Open Access Publishing Fund. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.CLU (clusterin) is a tumor suppressor gene that we have previously shown to be negatively modulated by the MYCN proto-oncogene, but the mechanism of repression was unclear. Here, we show that MYCN inhibits the expression of CLU by direct interaction with the non-canonical E box sequence CACGCG in the 5′-flanking region. Binding of MYCN to the CLU gene induces bivalent epigenetic marks and recruitment of repressive proteins such as histone deacetylases and Polycomb members. MYCN physically binds in vitro and in vivo to EZH2, a component of the Polycomb repressive complex 2, required to repress CLU. Notably, EZH2 interacts with the Myc box domain 3, a segment of MYC known to be essential for its transforming effects. The expression of CLU can be restored in MYCN-amplified cells by epigenetic drugs with therapeutic results. Importantly, the anticancer effects of the drugs are ablated if CLU expression is blunted by RNA interference. Our study implies that MYC tumorigenesis can be effectively antagonized by epigenetic drugs that interfere with the recruitment of chromatin modifiers at repressive E boxes of tumor suppressor genes such as CLU.SPARKS, The Neuroblastoma Society, a Wellcome Trust grant (to A. S.), and the Italian Association for Cancer Research

    Empirical models to quantify the nutritive characteristics of annual pastures in south-west Western Australia

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    The objective of this paper is to quantify the magnitude of the major sources of variation, which affect in vitro digestibility (DMD) and concentrations of neutral detergent fibre (NDF), acid detergent fibre (ADF), and crude protein (CP) of annual pastures in Mediterranean-type climate zones. Four experiments were conducted in the south-west of Western Australia in 2006–07 and 2007–08, where the supply of nitrogen, phosphorous, potassium, or sulfur and pasture types were varied. Effects of seasonality, fertiliser application, pasture type, and site were analysed with an auto-regression maximum likelihood procedure. Temperature sum was used to explain the seasonal differences in DMD, CP, NDF, and ADF. Seasonality explained 82, 79, 79, and 62% of the total variation in DMD, NDF, ADF, and CP, respectively, with only an additional 5, 5, 6, and 24% being explained by the combined effects of site/management, fertiliser application, and pasture type.The differences in DMD, NDF, ADF, and CP, between sites, were 2.3–6.0%, 4.6–18.7%, 5.8–8.6%, and 1.5–17.4%, respectively. Pasture types differed by 6.6–9.5%, 9.0–11.4%, 3.1–6.1%, and 5.1–5.2% for DMD, NDF, ADF, and CP, respectively. The differences between sites and pasture types were markedly larger for CP, NDF, and ADF than for DMD. Fertiliser application did not affect nutritive characteristics, with the exception of N application rates on CP. It was concluded that the seasonality model captured nearly all of the temporal variation in DMD, NDF, and ADF but not in CP. The spatial variation in DMD was mostly determined by pasture type. By comparison, NDF and ADF were most strongly affected by grazing management, and CP by the availability of N

    \u27Dermo\u27 fleece rot and body strike on sheep

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    Blowfly strike is one of the major problems confronting the sheep industry in Austrsalia, with an estimated totsalcost of control eceeding $100 million each year. Sheep are susceptible to five types of strike: body, breach, poll, pizzle and wound. Body strike, is of greater economic importance because its sporadic occurence from year to year makes it difficult to predict and cintrol. Outbreaks of body strike after rain can affect large numbers of sheep and inflict severe production losses. In eastern Australia fleece rot is generally considered to be the main predisposing factor to blowfly strike, but in Western Australia evidence suggests that dermatophilosis - or \u27dermo\u27 - is the more important factor
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