Laser Therapy After Repair of the Distal Half of the Median Nerve; a Comparative Study

Background: Nerve injuries resulting from major or minor trauma often cause some disabilities for patients. Neurotmesis, characterized by complete anatomical rupture of the nerve, is the most severe form of the injury which will not recover without reconstructive surgery and nowadays such neural damages are improved by microsurgical procedures. Some studies have used low power laser for nerve cell growth in order to improve the rehabilitation results of peripheral nerves. Low power laser can complement the reformation of postsurgical nerve injuries. Objectives: The current study aimed to assess the effects of laser therapy after repair of median nerve rupture in the distal third of the forearm and to compare the results with that of the standard method. Patients and Methods: The current study was a case-control clinical trial of 36 patients with volar surface rupture of the distal third of forearm admitted to the emergency ward of Hazrat-e-Fatemeh Hospital within 72 hours of injury, they had anesthesia in the first, second, and third fingers as a result of Median Nerve Injury. Patients were divided into two groups. The first group included subjects treated with standard methods and the second group included those treated with low power laser therapy (LT) along with the standard method. The same surgeon operated the subjects in the two groups. The second group underwent 10 sessions of LT every other day. Clinical Examination, Electromyography and Nerve Conduction Velocity (NCV) were done after six months and the results were compared. Results: In the two -point discrimination- test, there was no significant difference between the two groups in the thumbs but a significant improvement was observed in the index finger of the LT group. Improvement of muscular examinations such as opposition and thumb abduction supported the usage of laser in the second group. Regarding electromyography and NCV, significant statistical difference was observed in the motor part of the laser group and, to a great extent, was compatible with the physical examinations. Conclusions: Accordingly, laser therapy in our protocol seemed to affect some of the nerve growth parameters, mostly on motor rather than sensory fibers. Copyright © 2015, Trauma Monthly

A least squares solution to regionalize VTEC estimates for positioning applications

A new approach is presented to improve the spatial and temporal resolution of the Vertical Total Electron Content (VTEC) estimates for regional positioning applications. The proposed technique utilises a priori information from the Global Ionosphere Maps (GIMs) of the Center for Orbit Determination in Europe (CODE), provided in terms of Spherical Harmonic (SH) coefficients of up to degree and order 15. Then, it updates the VTEC estimates using a new set of base-functions (with better resolution than SHs) while using the measurements of a regional GNSS network. To achieve the highest accuracy possible, our implementation is based on a transformation of the GIM/CODE VTECs to their equivalent coefficients in terms of (spherical) Slepian functions. These functions are band-limited and reflect the majority of signal energy inside an arbitrarily defined region, yet their orthogonal property is remained. Then, new dual-frequency GNSS measurements are introduced to a Least Squares (LS) updating step that modifies the Slepian VTEC coefficients within the region of interest. Numerical application of this study is demonstrated using a synthetic example and ground-based GPS data in South America. The results are also validated against the VTEC estimations derived from independent GPS stations (that are not used in the modelling), and the VTEC products of international centres. Our results indicate that, by using 62 GPS stations in South America, the ionospheric delay estimation can be considerably improved. For example, using the new VTEC estimates in a Precise Point Positioning (PPP) experiment improved the positioning accuracy compared to the usage of GIM/CODE and Klobuchar models. The reductions in the root mean squared of errors were ∼23% and 25% for a day with moderate solar activity while 26% and ∼35% for a day with high solar activity, respectively

Comparison of accelerometer data calibration methods used in thermospheric neutral density estimation

Ultra-sensitive space-borne accelerometers on board of low Earth orbit (LEO) satellites are used to measure non-gravitational forces acting on the surface of these satellites. These forces consist of the Earth radiation pressure, the solar radiation pressure and the atmospheric drag, where the first two are caused by the radiation emitted from the Earth and the Sun, respectively, and the latter is related to the thermospheric density. On-board accelerometer measurements contain systematic errors, which need to be mitigated by applying a calibration before their use in gravity recovery or thermospheric neutral density estimations. Therefore, we improve, apply and compare three calibration procedures: (1) a multi-step numerical estimation approach, which is based on the numerical differentiation of the kinematic orbits of LEO satellites; (2) a calibration of accelerometer observations within the dynamic precise orbit determination procedure and (3) a comparison of observed to modeled forces acting on the surface of LEO satellites. Here, accelerometer measurements obtained by the Gravity Recovery And Climate Experiment (GRACE) are used. Time series of bias and scale factor derived from the three calibration procedures are found to be different in timescales of a few days to months. Results are more similar (statistically significant) when considering longer timescales, from which the results of approach (1) and (2) show better agreement to those of approach (3) during medium and high solar activity. Calibrated accelerometer observations are then applied to estimate thermospheric neutral densities. Differences between accelerometer-based density estimations and those from empirical neutral density models, e.g., NRLMSISE-00, are observed to be significant during quiet periods, on average 22 % of the simulated densities (during low solar activity), and up to 28 % during high solar activity. Therefore, daily corrections are estimated for neutral densities derived from NRLMSISE-00. Our results indicate that these corrections improve model-based density simulations in order to provide density estimates at locations outside the vicinity of the GRACE satellites, in particular during the period of high solar/magnetic activity, e.g., during the St. Patrick's Day storm on 17 March 2015

Interannual variability of temperature in the UTLS region over Ganges-Brahmaputra-Meghna river basin based on COSMIC GNSS RO data

Poor reliability of radiosonde records across South Asia imposes serious challenges in understanding the structure of upper-tropospheric and lower-stratospheric (UTLS) region. The Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) mission launched in April 2006 has overcome many observational limitations inherent in conventional atmospheric sounding instruments. This study examines the interannual variability of UTLS temperature over the Ganges-Brahmaputra-Meghna (GBM) river basin in South Asia using monthly averaged COSMIC radio occultation (RO) data, together with two global reanalyses. Comparisons between August 2006 and December 2013 indicate that MERRA (Modern-Era Retrospective Analysis for Research Application) and ERA-Interim (European Centre for Medium-Range Weather Forecasts reanalysis) are warmer than COSMIC RO data by 2°C between 200 and 50hPa levels. These warm biases with respect to COSMIC RO data are found to be consistent over time. The UTLS temperature show considerable interannual variability from 2006 to 2013 in addition to warming (cooling) trends in the troposphere (stratosphere). The cold (warm) anomalies in the upper troposphere (tropopause region) are found to be associated with warm ENSO (El Niño-Southern Oscillation) phase, while quasi-biennial oscillation (QBO) is negatively (positively) correlated with temperature anomalies at 70hPa (50hPa) level. PCA (principal component analysis) decomposition of tropopause temperatures and heights over the basin indicate that ENSO accounts for 73% of the interannual (non-seasonal) variability with a correlation of 0.77 with Niño3.4 index whereas the QBO explains about 10% of the variability. The largest tropopause anomaly associated with ENSO occurs during the winter, when ENSO reaches its peak. The tropopause temperature (height) increased (decreased) by about 1.5°C (300m) during the last major El Niño event of 2009/2010. In general, we find decreasing (increasing) trend in tropopause temperature (height) between 2006 and 2013

Improving the recovery of monthly regional water storage using one year simulated observations of two pairs of GRACE-type satellite gravimetry constellation

Increasing the spatial sampling isotropy is a major issue in designing future missions dedicated to continue the task of the Gravity Recovery And Climate Experiment (GRACE) mission. From various possible future satellite gravimetry scenarios, the two-pair multi-orbit satellite configuration (Bender-type in the sequence), consisting of a coupled semi-polar pair (the same as GRACE) and an inclined pair of satellites seems to be an optimal mission choice. This contribution examines the performance of a Bender-type scenario at altitudes of 335 km and 352 km and inclinations of 89° and 63°, respectively, for improving the regional recovery of hydrological signals. To this end, we created one full year of simulated observations of the GRACE and Bender-type configurations. Our investigations include: 1) evaluating the feasible spatial resolution for the recovery of terrestrial water storage (TWS) changes in the presence of realistic instrumental noise and errors in the background models; 2) assessing the influence of aliasing errors in the TWS recovery and its separation from instrumental noise and introduced hydrological signals; and 3) analyzing the regional quality of the gravity-derived TWS results by assessing water storage changes over the 33 world major river basins. From our simulations, the Bender-derived spectral error curves indicate that, in spite of the instrumental noise, aliasing errors still contaminate the gravity fields above geopotential spherical harmonic coefficient (SHC) degree and order (d/o) 80 till 100. Regarding to the TWS recovery, we found notable improvements for the Bender-type configuration results in medium and small-scale basins, such as the Brahmaputra, Euphrates, Ganges, Indus, Mekong basins in Asia and the Yellow and Orange basins in South Africa. These results were achieved without applying post-processing, which was unachievable using simulations of one pair of GRACE-like configuration. Comparing the magnitudes of errors in the Bender-derived solutions with those of GRACE indicate that the accuracy derived from the Bender-type fields is about two times better than that of GRACE, specifically at medium spatial resolutions of 250 km (SHC d/o 80). We truncated the TWS recovery up to SHC d/o 80 in the spectral domain, whereas all comparisons are demonstrated in the spatial domain after a truncation of the solutions and WGHM field at d/o 60, since beyond this range; a relatively strong instrumental and aliasing errors contaminate the solutions. Our numerical results indicate that the spatial resolution of the Bender-type TWS recovery can be even higher for the basins with strong temporal water storage variations such as the Amazon basin. Short wavelength mass variations in basins with relatively weaker temporal TWS magnitude, such as the Murray basin, might still need the application of a filter with small averaging kernel

Mechanistic Pathways of Malignancy in Breast Cancer Stem Cells.

Breast cancer stem cells (BCSCs) are the minor population of breast cancer (BC) cells that exhibit several phenotypes such as migration, invasion, self-renewal, and chemotherapy as well as radiotherapy resistance. Recently, BCSCs have been more considerable due to their capacity for recurrence of tumors after treatment. Recognition of signaling pathways and molecular mechanisms involved in stemness phenotypes of BCSCs could be effective for discovering novel treatment strategies to target BCSCs. This review introduces BCSC markers, their roles in stemness phenotypes, and the dysregulated signaling pathways involved in BCSCs such as mitogen-activated protein (MAP) kinase, PI3K/Akt/nuclear factor kappa B (NFκB), TGF-β, hedgehog (Hh), Notch, Wnt/β-catenin, and Hippo pathway. In addition, this review presents recently discovered molecular mechanisms implicated in chemotherapy and radiotherapy resistance, migration, metastasis, and angiogenesis of BCSCs. Finally, we reviewed the role of microRNAs (miRNAs) in BCSCs as well as several other therapeutic strategies such as herbal medicine, biological agents, anti-inflammatory drugs, monoclonal antibodies, nanoparticles, and microRNAs, which have been more considerable in the last decades