Kynance Cove; or the Cornish Smugglers. A tale of the last century.

Dialecto Literario. -- Dialecto de Cornwall. -- Pertenece a la colección LD-1800-1950 de The Salamanca Corpus. --William Bentinck Forfar, 1810-1895. -- Kynance Cove; or the Cornish Smugglers. A Tale of the Last Century. -- 1865.[ES] Novela que se desarrolla en Cornwall y que contiene dialecto de Cornwall. [EN] A novel that takes place in Cornwall and contains Cornish English

Common mortality modeling and coherent forecasts. An empirical analysis of worldwide mortality data

A new common mortality modeling structure is presented for analyzing mortality dynamics for a pool of countries, under the framework of generalized linear models (GLM). The countries are first classified by fuzzy c-means cluster analysis in order to construct the common sparse age-period model structure for the mortality experience. Next, we propose a method to create the common sex difference age-period model structure and then use this to produce the residual age-periodmodel structure for each country and sex. The time related principal components are extrapolated using dynamic linear regression (DLR) models and coherent mortality forecasts are investigated. We make use of mortality data from the “Human Mortality Database”

Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3

This project was supported by Queen Mary Innovation Ltd Proof of Concept Fund (2012/13) and The William Harvey Research Foundation

Severe transient left ventricular dysfunction induced by thyrotoxicosis

We report on a 44-year-old woman presenting with chest pain and dyspnoea without previous stress-related events. By means of echocardiography severe left ventricular dysfunction and wall motion abnormalities resembling stress-induced cardiomyopathy (Tako Tsubo) were seen. Laboratory investigation revealed thyrotoxicosis and elevated cardiac markers. Six days after starting medical treatment, complete restoration of the left ventricular function was observed. The transient left ventricular dysfunction was induced by thyrotoxicosis resembling stress-induced cardiomyopathy that resolved completely after medical treatment

Hyperthyroidism as a reversible cause of right ventricular overload and congestive heart failure

We describe a case of severe congestive heart failure and right ventricular overload associated with overt hyperthyroidism, completely reversed with antithyroid therapy in a few week. It represents a very unusual presentation of overt hyperthyroidism because of the severity of right heart failure. The impressive right ventricular volume overload made mandatory to perform transesophageal echo and angio-TC examination to exclude the coexistence of ASD or anomalous pulmonary venous return. Only a few cases of reversible right heart failure, with or without pulmonary hypertension, have been reported worldwide. In our case the most striking feature has been the normalization of the cardiovascular findings after six weeks of tiamazole therapy