The English towns and the War of the Roses

Submitted in partial fulfillment of the requirements for the degree of Master of ArtsText from page 5: "The growth, material progress and political power of the English towns in the fifteenth century may claim some attention. In this study nothing is more noticeable than the gradual breaking up of the feudal elements of society. Little by little feudal ties disappeared; conformably, the bonds of society were of different fibre. A statute of Richard the Second prohibiting livery end maintenance tells the story of the retainer in place of the vassal, the substitution which had told in favor of Edward the Third against the chivalry of France.Includes bibliographical references (pages 51-53)

Development of Novel Pyridazine Derivatives and Drug Delivery Systems Against Dengue

The lack of approved vaccines, medications and treatment regimens has significantly contributed to the rapid spread of mosquito-borne viruses such as Dengue and Zika virus. The complex immunopathology of these viruses presents limitations for the development and implementation of a definitive, safe and effective approach to combat infections.Previous research has demonstrated that vector control strategies such as the elimination of larval habitats, larviciding with insecticides, the use of biological agents and the application of adulticides have been unsuccessful in the reduction of viral transmission leading to the need for the continued development of antivirals. This research proposes an approach for a drug delivery system that involves novel antivirals that suppress dengue virus in an intracellular pH specific manner with the use of micellar nanoparticles. Drug-loaded nanoparticle that dissociates when exposed to a pH of 6.0, will release drug at the targeted location in the cell, in particular, the proximal trans-Golgi network in the cell. Three (3) novel pyridazine derivatives were analyzed and possessed anti-viral activity against Zika virus through the use of cell-culture based suppression techniques. The derivatives described in this thesis will be designed and analyzed for its future potential in drug encapsulation into newly synthesized mPEG-PLA comprised micellar nanoparticles

The effect of indentation force and displacement on visual perception of compliance

This paper investigates the effect of maximum indentation force and depth on people's ability to accurately discriminate compliance using indirect visual information only. Participants took part in two psychophysical experiments in which they were asked to choose the 'softest' sample out of a series of presented sample pairs. In the experiments, participants observed a computer-actuated tip indent the sample pairs to one of two conditions; maximum depth (10mm) or maximum force (4N). This indentation process simulates tool operated palpation in laparoscopic surgery. Results were used to plot psychometric functions as a measure of accuracy of compliance discriminability. A comparison indicated that participants performed best in the task where they judged samples being indented to a pre-set maximum force relying solely on visual cues, which demonstrates the effect of visual information on compliance discrimination. Results also show that indentation cues such as force and deformation depth have different effects on our ability to visually discriminate compliance. These findings will inform future work on designing a haptic feedback system capable of augmenting visual and haptic information independently for optimal compliance discrimination performance

Development and Characterisation of a Multi-material 3D Printed Torsion Spring

Compliant actuation methods are popular in robotics applications where interaction with complex and unpredictable environments and objects is required. There are a number of ways of achieving this, but one common method is Series Elastic Actuation (SEA). In a recent version of their Unified Snake robot, Choset et al. incorporated a Series Elastic Element (SEE) in the form of a rubber torsional spring. This pa- per explores the possibility of using multi-material 3D printing to produce similar SEEs. This approach would facilitate the fabrication and testing of different spring variants and minimise the assembly required. This approach is evaluated by characterizing the behavior of two printed SEEs with different dimensions. The springs exhibit predictable viscoelastic behavior that is well described by a five element Wiechert model. We find that individual springs behave predictably and that multiple copies of the same spring design exhibit good consistency

Typical Teaching Procedure for Socialized Activities in the Middle Grades

So rapid is the spread of the progressive movement in the schools that everywhere supervisors are urging their teachers to adopt newer ways of doing things. In many cases, however, teachers are concerned and at a loss as to where to turn for assistance. Too often teachers, urged on by eager supervisors and critics, blindly adopt mechanical and formal methods - isolated subject-matter units which are a mere succession of artificial topics

A simulation model for multi-channel, time-dependent queuing systems and an application to test and evaluate an analytical model of the U.S. Army Acute Minor Illness Clinics.

Many organizations exist within the Department of Defense which exhibit the properties of multi-channel, time-dependent queueing systems. One such system is the Army's Acute Minor Illness Clinic (AMIC) . Models of this system can be developed to determine optimum staffing levels and to upgrade the quality of service provided. This study developed a time-dependent simulation program which was applied to a two queue, multi-channel queueing system. In particular, this model was designed to test and evaluate the results of an analytical model of the AMIC. The results of both of these models are compared to a second simulation program which more closely models the AMIC in order to measure the significant differences between it and the two other models.http://archive.org/details/simulationmodelf00culmApproved for public release; distribution is unlimited

A soft multi-axial force sensor to assess tissue properties in RealTime

Objective: This work presents a method for the use of a soft multi-axis force sensor to determine tissue trauma in Minimally Invasive Surgery. Despite recent developments, there is a lack of effective haptic sensing technology employed in instruments for Minimally Invasive Surgery (MIS). There is thus a clear clinical need to increase the provision of haptic feedback and to perform real-time analysis of haptic data to inform the surgical operator. This paper establishes a methodology for the capture of real-time data through use of an inexpensive prototype grasper. Fabricated using soft silicone and 3D printing, the sensor is able to precisely detect compressive and shear forces applied to the grasper face. The sensor is based upon a magnetic soft tactile sensor, using variations in the local magnetic field to determine force. The performance of the sensing element is assessed and a linear response was observed, with a max hysteresis error of 4.1% of the maximum range of the sensor. To assess the potential of the sensor for surgical sensing, a simulated grasping study was conducted using ex vivo porcine tissue. Two previously established metrics for prediction of tissue trauma were obtained and compared from recorded data. The normalized stress rate (kPa.mm⁻¹) of compression and the normalized stress relaxation (ΔσR) were analyzed across repeated grasps. The sensor was able to obtain measures in agreement with previous research, demonstrating future potential for this approach. In summary this work demonstrates that inexpensive soft sensing systems can be used to instrument surgical tools and thus assess properties such as tissue health. This could help reduce surgical error and thus benefit patients

A novel multiple electrode direct current technique for characterisation of tissue resistance during surgery

Electrochemical and electrical characteristics have the potential to help differentiate between, and assess the health state of, different biological tissues. However, measurement and interpretation of these characteristics is non-trivial. We propose a new DC galvanostatic sensing method for application to laparoscopic cancer surgery. This presents a simple and cost-effective measurement coupled with straightforward data interpretation. This paper describes the electrochemical and electrical theory underpinning the technique. Additionally, we describe a measurement system employing this technique and present an investigation into the feasibility of using it for measuring the resistance of different tissue types. Measurements were performed on ex vivo porcine liver, colon and rectum tissues. Outputs were consistent with theory and showed a significant difference between the resistance of the different tissue types, (one-way ANOVA, F(2, 28) = 1369, p < 0.01). These findings indicate that this novel technique may be viable as a low cost method for the discrimination and health assessment of tissues in clinical scenarios

Evaluating the use of a novel low-cost measurement insole to characterise plantar foot strain during gait loading regimes

Introduction: Under plantar loading regimes, it is accepted that both pressure and shear strain biomechanically contribute to formation and deterioration of diabetic foot ulceration (DFU). Plantar foot strain characteristics in the at-risk diabetic foot are little researched due to lack of measurement devices. Plantar pressure comparatively, is widely quantified and used in the characterisation of diabetic foot ulceration risk, with a range of clinically implemented pressure measurement devices on the market. With the development of novel strain quantification methods in its infancy, feasibility testing and validation of these measurement devices for use is required. Initial studies centre on normal walking speed, reflecting common activities of daily living, but evaluating response to differing gait loading regimes is needed to support the use of such technologies for potential clinical translation. This study evaluates the effects of speed and inclination on stance time, strain location and strain response using a low-cost novel strain measurement insole.Methods: The STrain Analysis and Mapping of the Plantar Aspect (STAMPS) insole has been developed, and feasibility tested under self-selected normal walking speeds to characterise plantar foot strain, with testing beyond this limited regime required. A treadmill was implemented to standardise speed and inclination for a range of daily plantar loading conditions. A small cohort, comprising of five non-diabetic participants, were examined at slow (0.75 m/s), normal (1.25 m/s) and brisk (2 m/s) walking speeds and normal speed at inclination (10% gradient).Results: Plantar strain active regions were seen to increase with increasing speed across all participants. With inclination, it was seen that strain active regions reduce in the hindfoot and show a tendency to forefoot with discretionary changes to strain seen. Stance time decreases with increasing speed, as expected, with reduced stance time with inclination.Discussion: Comparison of the strain response and stance time should be considered when evaluating foot biomechanics in diabetic populations to assess strain time interval effects. This study supports the evaluation of the STAMPS insole to successfully track strain changes under differing plantar loading conditions and warrants further investigation of healthy and diabetic cohorts to assess the implications for use as a risk assessment tool for DFU