6,388 research outputs found

    Asymmetric accidental composite dark matter

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    The goal of this work is to find the simplest UV completion of Accidental Composite Dark Matter Models (ACDM) that can dynamically generate an asymmetry for the DM candidate, the lightest dark baryon (DCb), and simultaneously annihilate the symmetric component. In this framework the DCb is a bound state of a confining SU(N)(DC) gauge group, and can interact weakly with the visible sector. The constituents of the DCb can possess non-trivial charges under the Standard Model gauge group. The generation of asymmetry for such candidate is a two-flavor variation of the out-of-equilibrium decay of a heavy scalar, with mass M-phi greater than or similar to 10(10) GeV. Below the scale of the scalars, the models recover accidental stability, or long-livedness, of the DM candidate. The symmetric component is annihilated by residual confined interactions provided that the mass of the DCb m(DCb) less than or similar to 75 TeV. We implement the mechanism of asymmetry generation, or a variation of it, in all the original ACDM models, managing to generate the correct asymmetry for DCb of masses in this range. For some of the models found, the stability of the DM candidate is not spoiled even considering generic GUT completions or asymmetry generation mechanisms in the visible sector

    Dynamical analysis on f(R,G)f(R,\mathcal{G}) cosmology

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    We use a dynamical system approach to study the cosmological viability of f(R,G)f(R,\mathcal{G}) gravity theories. The method consists of formulating the evolution equations as an autonomous system of ODEs, using suitable variables. The formalism is applied to a class of models in which f(R,G)‚ąĚRnG1‚ąínf(R,\mathcal{G})\propto R^{n}\mathcal{G}^{1-n} and its solutions and corresponding stability are analysed in detail. New accelerating solutions that can be attractors in the phase space are found. We also find that this class of models does not exhibit a matter-dominated epoch, a solution which is inconsistent with current cosmological observations.Comment: 12 pages, 4 figures. Accepted for publication in Classical and Quantum Gravit

    Chromatin dynamics of the developmentally regulated P. lividus neural alpha tubulin gene

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    Over 40 years ago, Allfrey and colleagues (1964) suggested that two histone modifications, namely acetylation and methylation, might regulate RNA synthesis. Nowadays it is universally accepted that activation of gene expression strictly depends on enzymatic mechanisms able to dynamically modify chromatin structure. Here, using techniques including DNaseI hypersensitive site analysis, chomatin immunoprecipitation and quantitative PCR analysis, we have analyzed the dynamics of histone post-translation modifications involved in developmentally/spatially controlled activation of the sea urchin PlTalpha2 tubulin gene. We have demonstrated that only when the PlTalpha2 core promoter chromatin is acetylated on H3K9, tri-methylated on H3K4 and not di-methylated on H3K27, RNA pol II can be enrolled. In contrast, we have shown that when chromatin is methylated both on H3K9 (me2/3) and H3K27 (me2) and mono methylated on H3K4 the promoter is not accessible to RNA pol II. Our results suggest that, during P. lividus embryogenesis, both HAT/HDAC and HMT/HDM activities, which are able to regulate accessibility of the PlTalpha2 basal promoter to RNA polymerase II, are coordinately switched-on

    An Active High Impedance Surface for Low Profile Tunable and Steerable Antennas

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    In this letter, an approach for designing a tunable and steerable antenna is presented. The antenna model is based on a wideband bow-tie radiating element mounted above an active Artificial Magnetic Conductor (AMC). The AMC geometry consists of a Frequency Selective Surface (FSS) printed on a thin grounded dielectric slab in which some chip-set varactor diodes are placed between the metallic elements and the backing plane through vias. The resulting antenna can be tuned over the S-Band by simply changing all varactor capacitances through an appropriate biasing voltage. Moreover, this structure can operate a beam scanning over each working frequency by applying an appropriate biasing voltage to the active elements of the AMC surface in accordance to leaky radiation principles. The low profile active antenna is characterized by an overall thickness of 5.32 mm, which corresponds to approximately lambda/24 at the centre of the operating band.Comment: 4 pages, 13 figures

    Unveiling dark forces with the Large Scale Structure of the Universe

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    Cosmology offers opportunities to test Dark Matter independently of its interactions with the Standard Model. We study the imprints of long-range forces acting solely in the dark sector on the distribution of galaxies, the so-called Large Scale Structure (LSS). We derive the strongest constraint on such forces from a combination of Planck and BOSS data. Along the way we consistently develop, for the first time, the Effective Field Theory of LSS in the presence of new dynamics in the dark sector. We forecast that future surveys will improve the current bound by an order of magnitude.Comment: 5+18 pages, 4 figure

    In silico characterization of the neural alpha tubulin gene promoter of the sea urchin embryo Paracentrotus lividus by phylogenetic footprinting

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    During Paracentrotus lividus sea urchin embryo development one alpha and one beta tubulin genes are expressed specifically in the neural cells and they are early end output of the gene regulatory network that specifies the neural commitment. In this paper we have used a comparative genomics approach to identify conserved regulatory elements in the P. lividus neural alpha tubulin gene. To this purpose, we have first isolated a genomic clone containing the entire gene plus 4.5 Kb of 50 upstream sequences. Then, we have shown by gene transfer experiments that its non-coding region drives the spatiotemporal gene expression corresponding substantially to that of the endogenous gene. In addition, we have identified by genome and EST sequence analysis the S. purpuratus alpha tubulin orthologous gene and we propose a revised annotation of some tubulin family members. Moreover, by computational techniques we delineate at least three putative regulatory regions located both in the upstream region and in the first intron containing putative binding sites for Forkhead and Nkx transcription factor families

    The Transantral Endoscopic Approach: A Portal for Masses of the Inferior Orbit-Improving Surgeons' Experience Through Virtual Endoscopy and Augmented Reality

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    In the past years, endoscopic techniques have raised an increasing interest to perform minimally invasive accesses to the orbit, resulting in excellent clinical outcomes with inferior morbidities and complication rates. Among endoscopic approaches, the transantral endoscopic approach allows us to create a portal to the orbital floor, representing the most straightforward access to lesions located in the inferior orbital space. However, if endoscopic surgery provides enhanced magnified vision of the anatomy in a bloodless field, then it has several impairments compared with classic open surgery, owing to restricted operative spaces. Virtual surgical planning and anatomical computer-generated models have proved to be of great importance to plan endoscopic surgical approaches, and their role can be widened with the integration of surgical navigation, virtual endoscopy simulation, and augmented reality (AR). This study focuses on the strict conjugation between the technologies that allow the virtualization of surgery in an entirely digital environment, which can be transferred to the patient using intraoperative navigation or to a printed model using AR for pre-surgical analysis. Therefore, the interaction between different software packages and platforms offers a highly predictive preview of the surgical scenario, contributing to increasing orientation, awareness, and effectiveness of maneuvers performed under endoscopic guidance, which can be checked at any time using surgical navigation. In this paper, the authors explore the transantral approach for the excision of masses of the inferior orbital compartment through modern technology. The authors apply this technique for masses located in the inferior orbit and share their clinical results, describing why technological innovation, and, in particular, computer planning, virtual endoscopy, navigation, and AR can contribute to empowering minimally invasive orbital surgery, at the same time offering a valuable and indispensable tool for pre-surgical analysis and training
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