Frozen storage characteristics of cultured Macrobrachium rosenbergii (de Man)

Cultured Macrobrachium rosenbergii (Scampi, about 30 g each) in headless shell-on form was individually quick frozen in a spiral freezer. The frozen samples were glazed and packed in polythene bags, which were further packed in master carton and stored at -18°C. Samples were drawn at regular intervals and subjected to biochemical, bacteriological and organoleptic analysis to study its storage characteristics. The data on the above parameters showed that the samples were in prime acceptable condition when stored up to 23 weeks. No appreciable change in colour and odour was noticed in the raw muscle. Afterwards, organoleptic evaluation of the cooked muscle revealed slight change in the flavour. Texture also appeared little tougher. These changes in organoleptic characters were well supported by the biochemical bacteriological changes in the muscle

Formulation development and Stability Studies of Meropenem Extended-Release matrix Tablets

The aim of this research was to develop a new hydrophilic matrix system containing meropenem (MEX). Extended-release tablets are usually intended for once-a-day administration with benefits to the patient and lower discontinuation of the therapy. Formulations were developed with hydroxyl propyl methyl cellulose or poly (ethylene oxide) as hydrophilic polymers, with different molecular weights (MWs) and concentrations (20 and 30%). The tablets were found to be stable (6 months at 40 ± 2°C and 75± 5% relative humidity), and the film-coating process is recommended to avoid MEX photo-degradation. The dissolution profiles demonstrated an extended-release of MEX for all developed formulations. Dissolution curves analyzed using the Korsmeyer exponential equation showed that drug release was controlled by both drug diffusion and polymer relaxation or erosion mechanisms. A more erosion controlled system was obtained for the formulations containing lower MW and amount of polymer. With the increase in both MW and amount of polymer in the formulation, the gel layer became stronger, and the dissolution was more drug-diffusion dependent. Formulations containing intermediate MW polymers or high concentration (30%) of low MW polymers demonstrated a combination of extended and complete in vitro drug release. This way, these formulations could provide an increased bioavailability in vivo

Functional Movement Disorders in Elderly

Background: Functional movement disorders (FMDs) have been rarely described in the elderly population. Methods: This is a retrospective chart review of elderly patients with FMDs (onset >60 years) attending the movement disorders clinic at a tertiary care teaching institute in India. Results: Out of 117 patients diagnosed with FMD at our center, 18 patients had an onset after the age of 60 years. The male-to-female ratio was 10:8 and the duration of symptoms ranged from 1 day to 5 years. Social (10/18) and physical factors (5/18) with an evident temporal relationship with the onset of FMD were identified in 15 out of 18 patients. Six of them had a past history of depression, anxiety, or other psychiatric illnesses. The tremor was the most frequent phenomenology seen in 11 (61.1%) patients, followed by dystonia in seven (38.8%), choreoballism and tics in two each, and hemifacial spasm and functional gait in one each. Seven patients had more than one phenotype. Discussion: Tremor was the most frequent movement disorder seen in our patients with FMD. Surprisingly, tics (n = 2) and choreoballistic (n = 2) movements were also found in our patients with FMD, which has not been reported previously in an elderly population. Both physical and social factors were identified preceding the development of FMDs in majority of our patients

Exploration of Wound Healing Activity of Polyherbal Formulation

The present study was prepared wound healing activity of polyherbal formulation (lablab purpureous, Nerium indicum, Tebernamontana derivitacate) in Wister rat in excision and insision wound model. The appropriate gel formulation applied on tropically. Wound healing was monitored on Days 4, 8,12 and 16 days. and histological evaluation was carried out on the samples. The wound area of each animal was measured at the intervals of 24-48 hrs using transparent polythene graph paper and then tracing the area of wound on it. Contraction was calculated from the days of measurements of wound area. Keywords: Poly herbal formulation, Wound healing, Wound contraction

Synthesis and optical properties of CdTe nanocrystals with improved optical properties

CdTe nanocrystals are prepared by hydrothermal route using the reaction between Cd2+ and KHTe in the presence of thioglycolic acid as the stabilizing agent. Hydrothermal synthesis under optimum conditions resulted in a rapid growth. CdTe nanocrystals with high PL intensity and narrow PL spectra are obtained in less time. The growth mechanism of CdTe nanocrystals is investigated. The growth rate in the initial stage of synthesis is higher in hydrothermal synthesis resulting in an increased growth in diffusion controlled focused region

Gas Sensor Array Drift in an E-Nose System: A Dataset for Machine Learning Applications

Gas sensor arrays are widely used in various applications such as environmental monitoring, industrial process control, and medical diagnosis. However, one of the main challenges in using gas sensor arrays is their tendency to drift over time, which can significantly affect their accuracy and reliability. In this research paper, we present a gas sensor array drift dataset that can be used to evaluate and develop drift compensation techniques. The dataset consists of measurements from an array of eight metal oxide gas sensors exposed to six different target gases at varying concentrations over several months. The paper also describes the experimental setup, data acquisition process, and preliminary dataset analysis. Our results show that the sensor array exhibits significant drift over time and that the drift patterns vary depending on the target gas and concentration. This dataset can provide a valuable resource for researchers and engineers working on gas sensor array applications and can help advance the development of more robust and accurate gas sensing systems

Study of parametric optimization of fused deposition modelling process using response surface methodology

FDM(fused deposition modelling) is a RP(rapid prototyping)technique used to manufacture prototypes on additive manufacturing technology.The material used is ABS(acronitirile butadiene styrene) plastic.The prototypes are made layer by layer addition of semi molten plastic and their joining by diffusion welding.In the present study effect of different parameters on response is studied.RSM(response surface methodology) is used to build a regression model which can represent response in terms of different parameters. Influence of the process parameters on each factor is essentially studied and regression equation is built for each of strength under study.By using ANOVA analysis significant factors are considered and unsignificant factors are left out. After getting regression equation an optimized solution is obtained for each strengthby using a suitable mathematical software

Distributed diagnostics, prognostics and maintenance planning: Realizing industry 4.0

In this paper, a novel distributed yet integrated approach for diagnostics and prognostics is presented. An experimental study is conducted to validate the performance. Results showed that distributed prognostics give better performance in leaser computational time. Also, the proposed approach helps in making the results of the machine learning techniques comprehensible and more accurate. These results will be handy in arriving at predictive maintenance schedule considering the criticality of the system, the dependency of the components, available maintenance resources and confidence level in the results of the prognostic.Royal Academy of Engineering London, UK (IAPP 18-19/31

Subcutaneous Immunoglobulin-G Replacement Therapy with Preparations Currently Available in the United States for Intravenous or Intramuscular Use: Reasons and Regimens

For patients who require replacement therapy for primary immunodeficiency, subcutaneous infusions of immunoglobulin G (IgG) may be preferable to intravenous infusions for several reasons. However, at present, there is no preparation marketed for use by this route in North America. In this article, we describe the reasons patients have selected this route of therapy and the range of treatment regimens used. Approximately 20% of our patients have chosen the subcutaneous route, mainly because of adverse effects from intravenous (IV) infusions or difficulties with venous access. Unit dose regimens using whole bottles of currently available 16% intramuscular preparations or sucrose-containing lyophilized preparations intended for IV use but reconstituted to 15% IgG for subcutaneous administration were individually tailored to each patient. In most cases, self-infusions or home infusions were administered once or twice a week, most commonly requiring two subcutaneous sites and 2 to 3 hours per infusion. On average, patients took 0.18 mL of IgG per kilogram of body weight per site per hour. There were no systemic adverse effects. In patients for whom comparative data were available, trough serum IgG levels were higher with subcutaneous therapy than with IV therapy

Monitoring the status of Human-wildlife conflict and its impact on community based conservation in Bandhavgarh tiger reserve, Madhya Pradesh, India

The Bandhavgarh Tiger Reserve is one of the famous tiger reserve in India. The human wildlife conflict is on rise for few years. A total of 194 human casualties and 1960 livestock depredation were reported between 2001 to 2011. Out of 194 casualties, 6.7% were lethal which caused death and 93.3% were injuries. Out of these maximum 37.57% (68) were reported by Jackal (Canis aureus) followed by 27.64% (50) of Sloth bear (Melursus ursinus), 20.99% (38) by Wild boar (Sus scrofa), 8.84% (16) by Tiger (Panthera tigris), 3.31% (6) by Leopard (Panthera Pardus) and 1.65% (3) by other carnivores. Out of 194 casualties 71.13% were male and 28.87% were female. The livestock killings were reported to be 1960 out of which maximum 81.78% (1603) were by tiger followed by 17.60% (345) by leopard and rest 0.62% (12) by other carnivores. The mean livestock killing was 178.182±42.82 (SE) per year. Discussions and surveys were made with affected peoples to know the views about conflict and its alleviation by using Close ended questionnaire. Total 180 individuals were surveyed.  Out of these 151 (83.89 %) respondent felt that wildlife should be conserved while 29 (16.11 %) felt there is no need for conservation. Adequate compensation, habitat management practices, livestock and crop insurance scheme and bio fencing around the affected villages and conservation awareness could be the way to mitigate existing conflict.&nbsp