Paramagnetic energy levels of the ground state of Cr/+3/ in Al2O3

Paramagnetic energy levels of ground state of chromium 3 and aluminum oxide

Energy levels and transition matrix elements of paramagnetic crystals for maser applications

Univac computer programs for energy levels and transition probabilities for ruby and emerald

Low-noise K(u)-band receiver input system

Improved maser and superconducting magnet, which operates in vacuum of closed-cycle helium refrigerator, comprise a low-noise, reliable, field-operational receiver input system

ANALISIS KELEMBAGAAN PENGEMBANGAN HUTAN ADAT DESA TORO KECAMATAN KULAWI KABUPATEN SIGI PROVINSI SULAWESI TENGAH

This research aimed to revitalizethe local institution and its implication on the management of natural resources in Lore Lindu National Park area. The research was conducted at the village of Toro, Kulawi district, Sigi Regency, Central Sulawesi, from October through December 2013. The method used in this study is the method of historical and institutional analysis and qualitative approach by interview process on key informants as respondents.The results showed that institutional revitalization was influenced by community needs on institution development caused social dynamics and community economy. New institutional revitalization has implication on structure and regulation change of local institution of Toro village. Institution in Toro was contributed by local leadership role particularly in determination of natural resources and social economy. Keywords: Institution Analysis, Development, Community Forest, Toro Community

Investigation into Reliability of the Jubilee Line

Metro systems are often faced with reliability issues; specifically pertaining to safety, accessibility, train punctuality, and stopping accuracy. The project goal was to assess the reliability of the London Underground’s Jubilee Line and the systems implemented during the Jubilee Line extension. The team achieved this by interviewing train drivers and Transport for London employees, surveying passengers, validating the stopping accuracy of the trains, measuring dwell times, observing accessibility and passenger behavior on platforms with Platform Edge Doors, and overall train performance patterns

Effects of Freezing in Sweetened Dried Cranberry Production

The purpose of this project was to study and identify the effects of different freezing conditions on cranberries in Ocean SprayÂs Sweetened Dried Cranberry (SDC) process. By understanding how different freezing conditions affect the cellular structure of cranberries, these effects can be better accounted for during the SDC manufacturing process. The project involved a preliminary SDC lab-scale process design, and the development of a freezing method for yielding full batches of cranberries that underwent uniform freezing conditions. The freezing method concluded by this yearÂs project should be used by future teams in carrying and testing batches through the lab-scale process

IL-10 Immunomodulation of Myeloid Cells Regulates a Murine Model of Ovarian Cancer

Elevated levels of IL-10 in the microenvironment of human ovarian cancer and murine models of ovarian cancer are well established and correlate with poor clinical prognosis. However, amongst a myriad of immunosuppressive factors, the actual contribution of IL-10 to the ovarian tumor microenvironment, the mechanisms by which it acts, and its possible functional redundancy are unknown. We previously demonstrated that elimination of the myeloid-derived suppressor cell (MDSC) compartment within the ovarian tumor ascites inhibited tumor progression and, intriguingly, significantly decreased local IL-10 levels. Here we identify a novel pathway in which the tumor-infiltrating MDSC are the predominant producers of IL-10 and, importantly, require it to develop their immunosuppressive function in vivo. Importantly, we demonstrate that the role of IL-10 is critical, and not redundant with other immunosuppressive molecules, to in vivo tumor progression: blockade of the IL-10 signaling network results in alleviation of MDSC-mediated immunosuppression, altered T cell phenotype and activity, and improved survival. These studies define IL-10 as a fundamental modulator of both MDSC and T cells within the ovarian tumor microenvironment. Importantly, IL-10 signaling is shown to be necessary to the development and maintenance of a permissive tumor microenvironment and represents a viable target for anti-tumor strategies

Flagellar Motility Is a Key Determinant of the Magnitude of the Inflammasome Response to Pseudomonas aeruginosa

We previously demonstrated that bacterial flagellar motility is a fundamental mechanism by which host phagocytes bind and ingest bacteria. Correspondingly, loss of bacterial motility, consistently observed in clinical isolates from chronic Pseudomonas aeruginosa infections, enables bacteria to evade association and ingestion of P. aeruginosa by phagocytes both in vitro and in vivo. Since bacterial interactions with the phagocyte cell surface are required for type three secretion system-dependent NLRC4 inflammasome activation by P. aeruginosa, we hypothesized that reduced bacterial association with phagocytes due to loss of bacterial motility, independent of flagellar expression, will lead to reduced inflammasome activation. Here we report that inflammasome activation is reduced in response to nonmotile P. aeruginosa. Nonmotile P. aeruginosa elicits reduced IL-1β production as well as caspase-1 activation by peritoneal macrophages and bone marrow-derived dendritic cells in vitro. Importantly, nonmotile P. aeruginosa also elicits reduced IL-1β levels in vivo in comparison to those elicited by wild-type P. aeruginosa. This is the first demonstration that loss of bacterial motility results in reduced inflammasome activation and antibacterial IL-1β host response. These results provide a critical insight into how the innate immune system responds to bacterial motility and, correspondingly, how pathogens have evolved mechanisms to evade the innate immune system