36 research outputs found
Recommended from our members
Examination of T cell clones derived from patients receiving DLT relapse following bone marrow transplantation
Recommended from our members
Graft-versus-leukaemia effect (GVL) post allogeneic BMT is mediated by CML specific T cell clones
Recommended from our members
CD4 positive leukemia specific T cell clones are present during the graft-versus-leukemia response after allogeneic bone marrow transplantation for chronic myeloid leukemia
Recommended from our members
Graft-versus-leukaemia (GVL) effect post allogeneic BMT is mediated by CML specific T cell clones
Variability of definition of highârisk multiple myeloma across phase III clinical trials
Abstract The definition of highârisk multiple myeloma (HRMM) is evolving. Use of a clear definition of HRMM in clinical trials was not previously studied. We explored the definition of HRMM in completed phase III clinical trials. There is extreme variability in the definition and cutoffs used to define HRMM, with a significant number of studies lacking a clear definition. Our study provides a quantification of the variability in defining HRMM and suggests a need to better define HRMM in future clinical trials to enable more consistent treatment recommendations
Gene expression profiling impacts treatment decision making in newly diagnosed multiple myeloma patients in the prospective PROMMIS trial
Abstract Multiple myeloma (MM) is a heterogeneous hematologic malignancy associated with several risk factors including genetic aberrations which impact disease response and survival. Thorough risk classification is essential to select the best clinical strategy to optimize outcomes. The SKY92 molecular signature classifies patients as standardâ or highârisk for progression. The PRospective Observational Multiple Myeloma Impact Study (PROMMIS; NCT02911571) measures impact of SKY92 on risk classification and treatment plan. Newly diagnosed MM patients had bone marrow aspirates analyzed for SKY92. Physicians completed a questionnaire for each patient capturing risk classification, hypothetical treatment plan, and physician confidence in the treatment plan, before and after unblinding SKY92. One hundred forty seven MM patients were enrolled. Before unblinding SKY92, physicians regarded 74 (50%) patients as clinical standardârisk. After unblinding SKY92, 16 patients were reâassigned as highârisk by the physician, and for 15 of them treatment strategy was impacted, resulting in an escalated treatment plan. For the 73 (50%) clinical highârisk patients, SKY92 indicated 46 patients to be standardârisk; for 31 of these patients the treatment strategy was impacted consistent with a deâescalation of risk. Overall, SKY92 impacted treatment decisions in 37% of patients (p < 0.001). For clinical decisionâmaking, physicians incorporated SKY92, and the final assigned clinical risk was in line with SKY92 for 89% of patients. Furthermore, SKY92 significantly increased the confidence of the physiciansâ treatment decisions (p < 0.001). This study shows potential added value of SKY92 in MM for treatment decision making
Measurement of hadron and lepton-pair production at 161 GeV<root s<172 GeV at LEP
Contains fulltext :
26256.pdf (publisher's version ) (Open Access