2,277 research outputs found
Structural analysis of ultrafast extended x-ray absorption fine structure with subpicometer spatial resolution: Application to spin crossover complexes
We present a novel analysis of time-resolved extended x-ray absorption fine structure (EXAFS) spectra based on the fitting of the experimental transients obtained from optical pump/x-ray probe experiments. We apply it to the analysis of picosecond EXAFS data on aqueous [FeII (bpy)3] 2+, which undergoes a light induced conversion from its low-spin (LS) ground state to the short-lived (τ≈650 ps) excited high-spin (HS) state. A series of EXAFS spectra were simulated for a collection of possible HS structures from which the ground state fit spectrum was subtracted to generate transient difference absorption (TA) spectra. These are then compared with the experimental TA spectrum using a least-squares statistical analysis to derive the structural change. This approach reduces the number of required parameters by cancellation in the differences. It also delivers a unique solution for both the fractional population and the extracted excited state structure. We thus obtain a value of the Fe-N bond elongation in the HS state with subpicometer precision (0.203±0.008 Å). © 2009 American Institute of Physics.This work was funded by the Swiss National Science Foundation via Contract Nos. 620–066145, 200021–107956, PP002–110464, 200020–116023, 200021–105239, and 200020-116533.Peer Reviewe
Distribution and kinematics of the HCN(3-2) emission down to the innermost region in the envelope of the O-rich star W Hya
We report high angular resolution observations of the HCN (3-2) line emission
in the circumstellar envelope of the O-rich star W Hya with the Submillimeter
Array. The proximity of this star allows us to image its molecular envelope
with a spatial resolution of just ~40 AU, corresponding to about 10 times the
stellar diameter. We resolve the HCN (3-2) emission and find that it is
centrally peaked and has a roughly spherically symmetrical distribution. This
shows that HCN is formed in the innermost region of the envelope (within ~10
stellar radii), which is consistent with predictions from pulsation-driven
shock chemistry models, and rules out the scenario in which HCN forms through
photochemical reactions in the outer envelope. Our model suggests that the
envelope decreases steeply in temperature and increases smoothly in velocity
with radius, inconsistent with the standard model for mass-loss driven by
radiative pressure on dust grains. We detect a velocity gradient of ~5 km/s in
the NW--SE direction over the central 40 AU. This velocity gradient is
reminescent of that seen in OH maser lines, and could be caused by the rotation
of the envelope or by a weak bipolar outflow.Comment: accepted for publication in ApJ
Comparison of different pain scoring systems in critically ill patients in a general ICU
Background: Pain in critically ill patients in the intensive care unit (ICU) is common. However, pain assessment in critically ill patients often is complicated because these patients are unable to communicate effectively. Therefore, we designed a study (a) to determine the inter-rater reliability of the Numerical Rating Scale (NRS) and the Behavioral Pain Scale (BPS), (b) to compare pain scores of different observers and the patient, and (c) to compare NRS, BPS, and the Visual Analog Scale (VAS) for measuring pain in patients in the ICU. Methods: We performed a prospective observational study in 113 non-paralyzed critically ill patients. The attending nurses, two researchers, and the patient (when possible) obtained 371 independent observation series of NRS, BPS, and VAS. Data analyses were performed on the sample size of patients (n = 113). Results: Inter-rater reliability of the NRS and BPS proved to be adequate (kappa = 0.71 and 0.67, respectively). The level of agreement within one scale point between NRS rated by the patient and NRS scored by attending nurses was 73%. However, high patient scores (NRS ≥4) were underestimated by nurses (patients 33% versus nurses 18%). In responsive patients, a high correlation between NRS and VAS was found (rs= 0.84, P < 0.001). In ventilated patients, a moderate positive correlation was found between the NRS and the BPS (rs= 0.55, P < 0.001). However, whereas 6% of the observations were NRS of greater than or equal to 4, BPS scores were all very low (median 3.0, range 3.0 to 5.0). Conclusion: The different scales show a high reliability, but observer-based evaluation often underestimates the pain, particularly in the case of high NRS values (≥4) rated by the patient. Therefore, whenever this is possible, ICU patients should rate their pain. In unresponsive patients, primarily the attending nurse involved in daily care should score the patient's pain. In ventilated patients, the BPS should be used only in conjunction with the NRS nurse to measure pain levels in the absence of painful stimuli
Inactivation of the type I interferon pathway reveals long double‐stranded RNA ‐mediated RNA interference in mammalian cells
RNA interference (RNAi) elicited by long double-stranded (ds) or
base-paired viral RNA constitutes the major mechanism of antiviral
defence in plants and invertebrates. In contrast, it is controversial
whether it acts in chordates. Rather, in vertebrates, viral RNAs
induce a distinct defence system known as the interferon (IFN)
response. Here, we tested the possibility that the IFN response
masks or inhibits antiviral RNAi in mammalian cells. Consistent
with that notion, we find that sequence-specific gene silencing can
be triggered by long dsRNAs in differentiated mouse cells rendered
deficient in components of the IFN pathway. This unveiled response
is dependent on the canonical RNAi machinery and is lost upon
treatment of IFN-responsive cells with type I IFN. Notably, transfection with long dsRNA specifically vaccinates IFN-deficient cells
against infection with viruses bearing a homologous sequence.
Thus, our data reveal that RNAi constitutes an ancient antiviral
strategy conserved from plants to mammals that precedes but has
not been superseded by vertebrate evolution of the IFN system
ICESat Measurements Reveal Complex Pattern of Elevation Changes on Siple Coast Ice Streams, Antarctica
We compare ICESat data (2003-2004) to airborne laser altimetry data (1997-98 and 1999-2000) to monitor surface changes over portions of Van der Veen (VdVIS), Whillans (WIS) and Kamb ice streams (KIS) in the Ross Embayment of the West Antarctic Ice Sheet. The spatial pattern of detected surface changes is generally consistent with earlier observations. However, important changes have occurred during the past decade. For example, areas on the VdVIS and WIS, where large thinning was detected by the airborne surveys, are now closer to being in balance. The upper trunk of KIS continues to build up with thickening rates reaching 0.4 m/year. Our results provide new evidence that the overall mass balance of the region is becoming more positive, but a significant spatial variability exists. They also demonstrate the potential of ICESat data for detecting spatial patterns of surface elevation change in Antarctica
Tuberculosis-HIV Co-infection in Kiev City, Ukraine
In 2004, we tested all patients with newly diagnosed tuberculosis (TB) for HIV in Kiev City. The results were compared to information from medical records of 2002, when co-infection prevalence was 6.3%. Of 968 TB patients, 98 (10.1%) were HIV infected. TB-HIV co-infection is increasing, especially in injecting drug users
ICESat measurements reveal complex pattern of elevation changes on Siple Coast ice streams, Antarctica
This is the published version, also available here: http://dx.doi.org/10.1029/2005GL024289.We compare ICESat data (2003–2004) to airborne laser altimetry data (1997–98 and 1999–2000) to monitor surface changes over portions of Van der Veen (VdVIS), Whillans (WIS) and Kamb ice streams (KIS) in the Ross Embayment of the West Antarctic Ice Sheet. The spatial pattern of detected surface changes is generally consistent with earlier observations. However, important changes have occurred during the past decade. For example, areas on the VdVIS and WIS, where large thinning was detected by the airborne surveys, are now closer to being in balance. The upper trunk of KIS continues to build up with thickening rates reaching 0.4 m/year. Our results provide new evidence that the overall mass balance of the region is becoming more positive, but a significant spatial variability exists. They also demonstrate the potential of ICESat data for detecting spatial patterns of surface elevation change in Antarctica
Pulsations and Long-Term Light Variability of Three Candidates to Protoplanetary Nebulae
We present new photometric data and analysis of the long-duration UBV
photoelectric observations for three candidates to protoplanetary objects -
F-supergiants with IR-excesses located at large galactic latitudes, IRAS
18095+2704, IRAS 19386+0155, and IRAS 19500-1709. All three stars have revealed
quasiperiodic low-amplitude variabilities caused by pulsations observed against
the long-term trends of brightnesses. For IRAS 18095+2704=V887 Her we have
found a pulsation period of 109 days and a linear trend of brightness under the
constant colours if being averaged over the year timescale. The light curve of
IRAS 19386+0155=V1648 Aql over 2000-2008 can be approximated by a wave with a
main period of 102 days which is modulated by close frequency, with a period of
98 days, that results in brightness oscillations with a variable amplitude.
V1648 Aql has also shown synchronous reddening together with a persistent rise
of brightness in the V-band. IRAS 19500-1709=V5112 Sgr experiences irregular
pulsations with the periods of 39 and 47 days. The long-term component of the
variability of V5112 Sgr may be related to the binary character of this star.Comment: 11 pages, 6 figures, accepted for publication in Pis'ma Astron. Z
- …