106 research outputs found
ΠΡΡΠΎΡΠΈΠ°ΡΠΈΡ Π°Π»Π»Π΅Π»ΡΠ½ΡΡ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠ² Π³Π΅Π½Π° ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ NO-ΡΠΈΠ½ΡΠ°Π·Ρ Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΡΠ΅ΡΠ΄ΡΠ° (Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ½ΡΠΉ ΠΎΠ±Π·ΠΎΡ)
ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΉ Π°Π½Π°Π»ΡΠ· Π²ΡΡΡΠΈΠ·Π½ΡΠ½ΠΈΡ
ΡΠ° Π·Π°ΠΊΠΎΡΠ΄ΠΎΠ½Π½ΠΈΡ
Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Ρ ΡΡΠΎΡΠΎΠ²Π½ΠΎ Π²ΠΈΠ²ΡΠ΅Π½Π½Ρ Π²ΠΏΠ»ΠΈΠ²Ρ Π’-786Π‘, G894T, 4a/b ΠΏΠΎΠ»ΡΠΌΠΎΡΡΡΠ·ΠΌΡΠ² Π³Π΅Π½Ρ eNOS Π½Π° ΡΠΈΠ·ΠΈΠΊ ΡΠΎΠ·Π²ΠΈΡΠΊΡ ΠΠ₯Π‘ Ρ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π½ΠΈΠΊΡΠ² ΡΡΠ·Π½ΠΈΡ
ΠΏΠΎΠΏΡΠ»ΡΡΡΠΉ. ΠΠΎΠ²Π΅Π΄Π΅Π½Π° ΡΠΎΠ»Ρ Π’-786 Π‘ ΠΏΠΎΠ»ΡΠΌΠΎΡΡΡΠ·ΠΌΠ° Π³Π΅Π½Ρ eNOS Ρ ΡΠΎΠ·Π²ΠΈΡΠΊΡ ΠΠ₯Π‘ Ρ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π½ΠΈΠΊΡΠ² ΡΠΏΠΎΠ½ΡΡΠΊΠΎΡ, ΡΠΊΡΠ°ΡΠ½ΡΡΠΊΠΎΡ, ΡΡΠ°Π»ΡΠΉΡΡΠΊΠΎΡ ΠΏΠΎΠΏΡΠ»ΡΡΡΡ, ΠΏΡΠΈΡΠΎΠΌΡ Π² ΠΎΡΡΠ°Π½Π½ΡΡ
Π²ΡΠ½ ΠΏΠΎΠ²βΡΠ·Π°Π½ΠΈΠΉ ΡΠ· Π±Π°Π³Π°ΡΠΎΡΡΠ΄ΠΈΠ½Π½ΠΈΠΌ ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠΌ. G894T ΠΏΠΎΠ»ΡΠΌΠΎΡΡΡΠ·ΠΌ Π³Π΅Π½Ρ eNOS ΠΏΠΎΠ²βΡΠ·Π°Π½ΠΈΠΉ ΡΠ· ΠΏΡΠ΄Π²ΠΈΡΠ΅Π½ΠΈΠΌ ΡΠΈΠ·ΠΈΠΊΠΎΠΌ ΡΠΎΠ·Π²ΠΈΡΠΊΡ ΠΠ₯Π‘, ΡΡΠ΅ΠΌΡΡΠ½ΠΈΡ
ΡΠ½ΡΡΠ»ΡΡΡΠ² Π² ΡΡΠ°Π»ΡΠΉΡΡΠΊΡΠΉ, ΡΡΡΠ΅ΡΡΠΊΡΠΉ, Π°Π·ΡΠ°ΡΡΡΠΊΡΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΡΡΡ
, Π° Π² ΡΠΎΡΡΠΉΡΡΠΊΡΠΉ β ΡΠ· ΡΠ΅ΡΡΠ΅Π½ΠΎΠ·Π°ΠΌΠΈ ΡΡΠ΅Π½ΡΡΠ². ΠΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΉ Π·Π²βΡΠ·ΠΎΠΊ 4Π°/4b ΠΏΠΎΠ»ΡΠΌΠΎΡΡΡΠ·ΠΌΡ Π³Π΅Π½Ρ eNOS ΡΠ· Π²ΠΈΠ½ΠΈΠΊΠ½Π΅Π½Π½ΡΠΌ ΠΠ₯Π‘ Ρ ΡΡΡΠ΅ΡΡΠΊΡΠΉ, ΡΠΏΠΎΠ½ΡΡΠΊΡΠΉ, ΠΊΠΎΡΠ΅ΠΉΡΡΠΊΡΠΉ, Π°ΡΡΠΎ-Π°ΠΌΠ΅ΡΠΈΠΊΠ°Π½ΡΡΠΊΡΠΉ, ΡΡΠ°Π½ΡΡΠΊΡΠΉ, ΡΠΎΡΡΠΉΡΡΠΊΡΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΡΡΡ
, Π° Π² ΡΠΏΠΎΠ½ΡΡΠΊΡΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΡΡ β Π³Π΅Π½Π΄Π΅ΡΠ½Π° ΡΠΏΠ΅ΡΠΈΡΡΠΊΠ° Π΄Π°Π½ΠΎΡ Π°ΡΠΎΡΡΠ°ΡΡΡ. Π ΠΎΠΊΡΠ΅ΠΌΠΈΡ
Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½ΡΡ
ΠΎΡΡΠΈΠΌΠ°Π½Ρ ΡΡΠΏΠ΅ΡΠ΅ΡΠ»ΠΈΠ²Ρ Π΄Π°Π½Ρ ΡΠΎΠ΄ΠΎ Π²ΠΏΠ»ΠΈΠ²Ρ Π’-786 Π‘ ΠΏΠΎΠ»ΡΠΌΠΎΡΡΡΠ·ΠΌΡ Π³Π΅Π½Ρ eNOS Π² ΡΡΡΠ΅ΡΡΠΊΡΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΡΡ. ΠΠ΅ Π²ΠΈΡΠ²Π»Π΅Π½ΠΎ Π°ΡΠΎΡΡΠ°ΡΡΡ 4Π°/4b ΠΏΠΎΠ»ΡΠΌΠΎΡΡΡΠ·ΠΌΡ Π³Π΅Π½Ρ eNOS Ρ ΡΠΎΠ»ΠΎΠ²ΡΠΊΡΠ² Π‘Π»ΠΎΠ²Π΅Π½ΡΡ, Π€ΡΠ½Π»ΡΠ½Π΄ΡΡ, G894T ΠΏΠΎΠ»ΡΠΌΠΎΡΡΡΠ·ΠΌΡ Π³Π΅Π½Ρ eNOS Ρ ΠΊΠΎΡΠ΅ΠΉΡΡΠΊΡΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΡΡ, Π° Ρ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π½ΠΈΠΊΡΠ² Π±ΡΠ»ΠΎΡ Π°Π²ΡΡΡΠ°Π»ΡΠΉΡΡΠΊΠΎΡ ΠΏΠΎΠΏΡΠ»ΡΡΡΠΉ Π½Π΅ Π²ΠΈΡΠ²Π»Π΅Π½ΠΎ Π°ΡΠΎΡΡΠ°ΡΡΡ Π³Π΅Π½ΠΎΡΠΈΠΏΡΠ² 4Π°/4b, G894T, Π’-786Π‘ ΠΏΠΎΠ»ΡΠΌΠΎΡΡΡΠ·ΠΌΡ Π³Π΅Π½Ρ eNOS ΡΠ· ΡΠΈΠ·ΠΈΠΊΠΎΠΌ ΡΠΎΠ·Π²ΠΈΡΠΊΡ ΠΠ₯Π‘.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΈ Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΡ
ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π²Π»ΠΈΡΠ½ΠΈΡ Π’-786Π‘, G894T, 4a/b ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠ² Π³Π΅Π½Π° eNOS Π½Π° ΡΠΈΡΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΠΠ‘ Ρ ΠΏΡΠ΅Π΄ΡΡΠ°Π²ΠΈΡΠ΅Π»Π΅ΠΉ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΉ. ΠΠΎΠΊΠ°Π·Π°Π½Π° ΡΠΎΠ»Ρ Π’-786 Π‘ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½Π° eNOS Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΠΠΠ‘ Ρ ΠΏΡΠ΅Π΄ΡΡΠ°Π²ΠΈΡΠ΅Π»Π΅ΠΉ ΡΠΏΠΎΠ½ΡΠΊΠΎΠΉ, ΡΠΊΡΠ°ΠΈΠ½ΡΡΠΊΠΎΠΉ, ΠΈΡΠ°Π»ΡΡΠ½ΡΠΊΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ, ΠΏΡΠΈΡΠ΅ΠΌ Ρ ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΡ
ΠΎΠ½ ΡΠ²ΡΠ·Π°Π½ Ρ ΠΌΠ½ΠΎΠ³ΠΎΡΠΎΡΡΠ΄ΠΈΡΡΡΠΌ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ. G894T ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌ Π³Π΅Π½Π° eNOS ΡΠ²ΡΠ·Π°Π½ Ρ ΠΏΠΎΠ²ΡΡΠ΅Π½ΡΠΌ ΡΠΈΡΠΊΠΎΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΠ₯Π‘, ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠ½ΡΡΠ»ΡΡΠΎΠ² Π² ΠΈΡΠ°Π»ΡΡΠ½ΡΠΊΠΎΠΉ, ΡΡΡΠ΅ΡΠΊΠΎΠΉ, Π°Π·ΠΈΠ°ΡΡΠΊΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΡΡ
, Π° Π² ΡΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ β Ρ ΡΠ΅ΡΡΠ΅Π½ΠΎΠ·Π°ΠΌΠΈ ΡΡΠ΅Π½ΡΠΎΠ². ΠΠΎΠΊΠ°Π·Π°Π½Π° ΡΠ²ΡΠ·Ρ 4Π°/4b ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½Π° eNOS Ρ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΠ΅ΠΌ ΠΠΠ‘ Π² ΡΡΡΠ΅ΡΠΊΠΎΠΉ, ΡΠΏΠΎΠ½ΡΠΊΠΎΠΉ, ΠΊΠΎΡΠ΅ΠΉΡΠΊΠΎΠΉ, Π°ΡΡΠΎ-Π°ΠΌΠ΅ΡΠΈΠΊΠ°Π½ΡΠΊΠΎΠΉ, ΠΈΡΠ°Π½ΡΡΠΊΠΎΠΉ, ΡΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΡΡ
, Π° Π² ΡΠΏΠΎΠ½ΡΠΊΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ β Π³Π΅Π½Π΄Π΅ΡΠ½Π°Ρ ΡΠΏΠ΅ΡΠΈΡΠΈΠΊΠ° Π΄Π°Π½Π½ΠΎΠΉ Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΈ. Π ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ
ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ ΠΏΡΠΎΡΠΈΠ²ΠΎΡΠ΅ΡΠΈΠ²ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠΈ Π’-786 Π‘ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½Π° eNOS Π² ΡΡΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ. ΠΠ΅ Π²ΡΡΠ²Π»Π΅Π½ΠΎ Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΈ 4Π°/4b ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½Π° eNOS Ρ ΠΌΡΠΆΡΠΈΠ½ Π‘Π»ΠΎΠ²Π΅Π½ΠΈΠΈ, Π€ΠΈΠ½Π»ΡΠ½Π΄ΠΈΠΈ, G894T ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½Π° eNOS Π² ΠΊΠΎΡΠ΅ΠΉΡΠΊΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ, Π° Ρ ΠΏΡΠ΅Π΄ΡΡΠ°Π²ΠΈΡΠ΅Π»Π΅ΠΉ Π±Π΅Π»ΠΎΠΉ Π°Π²ΡΡΡΠ°Π»ΠΈΠΉΡΠΊΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ Π½Π΅ Π²ΡΡΠ²Π»Π΅Π½ΠΎ Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΈ Π³Π΅Π½ΠΎΡΠΈΠΏΠΎΠ² 4Π°/4b, G894T, Π’-786Π‘ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΡ Π³Π΅Π½Ρ eNOS Ρ ΡΠΈΡΠΊΠΎΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΠΠ‘.The article analyzed Ukrainian and foreign research on the impact
study T-786Π‘, G894T, 4a /b polymorphisms of the eNOS gene on the
risk of coronary artery disease (CAD) among representatives of different
populations. The role of T-786C polimorphism of the eNOS gene
was proven in the development of CAD among Japanese, Ukrainian,
Italian population, and in the past it is associated with multivessel disease.
G894T polymorphism of the eNOS gene is associated with high
risk of CAD, ischemic stroke in Italian, Turkish, Asian populations. In
the Russian population this polymorphism assotiated with restenosis of
stents. The 4a/4b polymorphism of the eNOS gene has significant influence
on risk of CAD in Turkish, Japanese, Korean, AfricanAmerican,
Iranian and Russian populations. Japanese population has
gender specificity of the association. Conflicting data obtained in separate
studies of the influence of T-786C polymorphism of the eNOS
gene in the Turkish population. There was no association 4a /4b polymorphism
of the eNOS gene in men Sloveniaβs men and in Finland.
Wasnβt identify association of G894T polymorphism of the eNOS
gene in Korean population. Wasnβt detected association of genotypes
4a/4b, G894T, T-786S of the eNOS gene polymorphisms with risk of
CAD in white Australians.
Due to the existence of common pathogenetic mechanisms, involving
NO, polymorphism eNOS gene presence may increases the risk of
developing COPD. So perspective is study of polymorphisms eNOS
gene in patients with COPD and CAD of Ukrainian population. Investigate
their role as candidate genes can help to predict and prevent the
appearance of comorbid disorders
Association between serum uric acid, aortic, carotid and femoral stiffness among adults aged 40-75 years without and with type 2 diabetes mellitus: The Maastricht Study
Objective: Arterial stiffness may be a mechanism to explain the association between uric acid and cardiovascular disease. We aimed to analyse associations between serum uric acid and regional and local arterial stiffness, and assess potential differences related to sex and glucose metabolism status. Methods: A cross-sectional study was performed in 614 adults [52.6% men; mean age 58.7 +/- 8.5 years; 23.2% type 2 diabetes mellitus (by design)] from The Maastricht Study. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV), distensibility, and compliance coefficient of the carotid and femoral artery, and carotid artery Young's elastic modulus. Results: Higher uric acid (per SD of 74 mu mol/l) was associated with greater stiffness indicated by a significantly higher cfPWV [beta = 0.216 (95% confidence interval 0.061, 0.372); P = 0.006] and lower carotid distensibility coefficient [beta = -0.633 (95% confidence interval -1.099, -0.166); P = 0.008] after adjustment for sex, age, and glucose metabolism status. Associations lost significance after adjusting for mean arterial pressure, BMI, waist, smoking status, heart rate, total : high-density lipoprotein cholesterol ratio, triglycerides, estimated glomerular filtration rate, use of lipid-lowering, antihypertensive, and diabetes medication, and use of secondary uricosurics. No associations were found between uric acid and carotid compliance coefficient, carotid Young's elastic modulus, or stiffness of the femoral artery. A significant interaction (P <0.10) with glucose metabolism status was found for cfPWV. However, none of the stratified associations were significant. There was no interaction with sex. Conclusion: Uric acid was not significantly associated with stiffness of the aorta, or the carotid or femoral artery among adults aged 40-75 years without and with type 2 diabetes mellitus
ΠΠ΅Π±-ΡΠ΅ΡΡΡΡ Π΄Π»Ρ ΠΏΠ΅ΡΠ΅Π³Π»ΡΠ΄Ρ 3D ΠΌΠΎΠ΄Π΅Π»Π΅ΠΉ Π· Π²ΠΈΠΊΠΎΡΠΈΡΡΠ°Π½Π½ΡΠΌ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΡΡ WebGL
Π£ ΠΏΠ΅ΡΡΠΎΠΌΡ ΡΠΎΠ·Π΄ΡΠ»Ρ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΡΡΡΡΡΡ Π°ΠΊΡΡΠ°Π»ΡΠ½ΡΡΡΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΈ, ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡΡΡ Π°Π½Π°Π»ΡΠ· ΡΡΠ½ΡΡΡΠΈΡ
Π°Π½Π°Π»ΠΎΠ³ΡΠ². ΠΡΡΠ³ΠΈΠΉ ΡΠΎΠ·Π΄ΡΠ» ΠΏΡΠΈΡΠ²ΡΡΠ΅Π½ΠΈΠΉ ΡΠΎΡΠΌΡΠ²Π°Π½Π½Ρ ΠΌΠ΅ΡΠΈ Π΄ΠΈΠΏΠ»ΠΎΠΌΠ½ΠΎΡ ΡΠΎΠ±ΠΎΡΠΈ ΡΠ° Π·Π°Π΄Π°Ρ ΠΏΡΠΎΠ΅ΠΊΡΡ, Π²ΠΈΠ±ΠΎΡΡ Π·Π°ΡΠΎΠ±ΡΠ² ΡΠ΅Π°Π»ΡΠ·Π°ΡΡΡ ΡΠ° ΠΏΠ»Π°Π½ΡΠ²Π°Π½Π½Ρ ΡΠΎΠ±ΡΡ. Π£ ΡΡΠ΅ΡΡΠΎΠΌΡ ΡΠΎΠ·Π΄ΡΠ»Ρ Π²ΠΈΠΊΠΎΠ½ΡΡΡΡΡΡ ΠΏΡΠΎΠ΅ΠΊΡΡΠ²Π°Π½Π½Ρ Π²Π΅Π±-ΡΠ΅ΡΡΡΡΡ, Π΄Π΅ Π½Π°Π²Π΅Π΄Π΅Π½Ρ Π΄ΡΠ°Π³ΡΠ°ΠΌΠΈ Ρ Π½ΠΎΡΠ°ΡΡΡ IDF0 ΡΠ° Use Case.ΠΡΡΠ°Π½Π½ΡΠΉ ΡΠΎΠ·Π΄ΡΠ» ΠΏΡΠΈΡΠ²ΡΡΠ΅Π½ΠΈΠΉ Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠΌΡ ΠΎΠΏΠΈΡΡ ΠΏΡΠ°ΠΊΡΠΈΡΠ½ΠΎΡ ΡΠ΅Π°Π»ΡΠ·Π°ΡΡΡ ΠΏΡΠΎΠ΅ΠΊΡΡ: Π²ΠΈΠΊΠΎΠ½Π°Π½Π½Ρ ΠΏΡΠΎΡΠΎΡΠΈΠΏΡΠ²Π°Π½Π½Ρ Π²Π΅Π±-ΡΡΠΎΡΡΠ½ΠΊΠΈ, ΡΠΎΠ·ΠΌΡΡΠΊΠ° ΡΠ° ΡΠΎΡΠΌΠ°ΡΡΠ²Π°Π½Π½Ρ Π²Π΅Π±-ΡΠ΅ΡΡΡΡΡ, Π½Π°Π»Π°ΡΡΡΠ²Π°Π½Π½Ρ ΡΠ° ΠΏΠ΅ΡΠ΅Π²ΡΡΠΊΠ° ΠΏΡΠ°ΡΠ΅Π·Π΄Π°ΡΠ½ΠΎΡΡΡ Π²Π΅Π±-Π±ΡΠ°ΡΠ·Π΅ΡΠ° Π· WebGL, ΠΎΠΏΠΈΡ ΡΠ΅Π°ΠΊΡΡΡ Π½Π° Π΄ΡΡ ΠΊΠΎΡΠΈΡΡΡΠ²Π°ΡΠ°, ΡΠΎΠ·ΡΠΎΠ±ΠΊΠ° ΡΡΠ½ΠΊΡΡΠΉ ΠΌΠ°Π½ΡΠΏΡΠ»ΡΡΡΠΉ Π½Π°Π΄ ΠΌΠΎΠ΄Π΅Π»Π»Ρ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠΌ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎΡ ΡΠΎΠ±ΠΎΡΠΈ Ρ ΡΠΎΠ·ΡΠΎΠ±Π»Π΅Π½ΠΈΠΉ Π²Π΅Π±-ΡΠ΅ΡΡΡΡ, ΡΠΊΠΈΠΉ Π΄ΠΎΠ·Π²ΠΎΠ»ΡΡ ΠΊΠΎΡΠΈΡΡΡΠ²Π°ΡΡ ΠΎΠ±ΠΈΡΠ°ΡΠΈ ΠΎΠ΄Π½Ρ ΡΠ· ΡΠΎΡΠΈΡΡΠΎΡ
ΠΌΠΎΠ΄Π΅Π»Π΅ΠΉ Π΄Π»Ρ Π²ΡΠ·ΡΠ°Π»ΡΠ·Π°ΡΡΡ Π½Π° Π²Π΅Π±-ΡΡΠΎΡΡΠ½ΡΡ ΡΠ° Π²ΠΈΠΊΠΎΠ½ΡΠ²Π°ΡΠΈ Π±Π°Π·ΠΎΠ²Ρ ΠΌΠ°Π½ΡΠΏΡΠ»ΡΡΡΡ Π· Π½Π΅Ρ
Associations of Advanced Glycation End-Products With Cognitive Functions in Individuals With and Without Type 2 Diabetes: The Maastricht Study
Context: Advanced glycation end-products (AGEs) are thought to be involved in the pathogenesis of Alzheimer's disease. AGEs are products resulting from nonenzymatic chemical reactions between reduced sugars and proteins, which accumulate during natural aging, and their accumulation is accelerated in hyperglycemic conditions such as type 2 diabetes mellitus. Objective: The objective of the study was to examine associations between AGEs and cognitive functions. Design, Setting, and Participants: This study was performed as part of the Maastricht Study, a population-based cohort study in which, by design, 215 participants (28.1%) had type 2 diabetes mellitus. Main Outcome Measures: We examined associations of skin autofluorescence (SAF) (n = 764), an overall estimate of skin AGEs, and specific plasma protein-bound AGEs (n = 781) with performance on tests for global cognitive functioning, information processing speed, verbal memory (immediate and delayed word recall), and response inhibition. Results: After adjustment for demographics, diabetes, smoking, alcohol, waist circumference, total cholesterol/high-density lipoprotein cholesterol ratio, triglycerides, and lipid-lowering medication use, higher SAF was significantly associated with worse delayed word recall (regression coefficient, b = - 0.44; P = .04), and response inhibition (b = 0.03; P = .04). After further adjustment for systolic blood pressure, cardiovascular disease, estimated glomerular filtration rate, and depression, associations were attenuated (delayed word recall, b = - 0.38, P = .07; response inhibition, b = 0.02, P = .07). Higher pentosidine levels were associated with worse global cognitive functioning (b = - 0.61; P = .04) after full adjustment, but other plasma AGEs were not. Associations did not differ between individuals with and without diabetes. Conclusion: We found inverse associations of SAF (a noninvasive marker for tissue AGEs) with cognitive performance, which were attenuated after adjustment for vascular risk factors and depression
Exercise SBP response and incident depressive symptoms: The Maastricht Study
Objective : An exaggerated exercise SBP, which is potentially modifiable, may be associated with incident depressive symptoms via an increased pulsatile pressure load on the brain. However, the association between exaggerated exercise SBP and incident depressive symptoms is unknown. Therefore, we examined whether exaggerated exercise SBP is associated with a higher risk of depressive symptoms over time. Methods : We used longitudinal data from the population-based Maastricht Study, with only individuals free of depressive symptoms at baseline included (n = 2121; 51.3% men; age 59.5 +/- 8.5 years). Exercise SBP was measured at baseline with a submaximal exercise cycle test. We calculated a composite score of exercise SBP based on four standardized exercise SBP measures: SBP at moderate workload, SBP at peak exercise, SBP change per minute during exercise and SBP 4 min after exercise. Clinically relevant depressive symptoms were determined annually at follow-up and defined as a Patient Health Questionnaire score of at least 10. Results : After a mean follow-up of 3.9 years, 175 participants (8.3%) had incident clinically relevant depressive symptoms. A 1 SD higher exercise SBP composite score was associated with a higher incidence of clinically relevant depressive symptoms [hazard ratio: 1.27 (95% confidence interval: 1.04-1.54)]. Results were adjusted for age, sex, education level, glucose metabolism status, lifestyle, cardiovascular risk factors, resting SBP and cardiorespiratory fitness. Conclusion : A higher exercise SBP response is associated with a higher incidence of clinically relevant depressive symptoms
Multiple inflammatory biomarker detection in a prospective cohort study: a cross-validation between well-established single-biomarker techniques and electrochemiluminescense-based multi-array platform
Background - In terms of time, effort and quality, multiplex technology is an attractive alternative for well-established single-biomarker measurements in clinical studies. However, limited data comparing these methods are available. Methods - We measured, in a large ongoing cohort study (n = 574), by means of both a 4-plex multi-array biomarker assay developed by MesoScaleDiscovery (MSD) and single-biomarker techniques (ELISA or immunoturbidimetric assay), the following biomarkers of low-grade inflammation: C-reactive protein (CRP), serum amyloid A (SAA), soluble intercellular adhesion molecule 1 (sICAM-1) and soluble vascular cell adhesion molecule 1 (sVCAM-1). These measures were realigned by weighted Deming regression and compared across a wide spectrum of subjectsβ cardiovascular risk factors by ANOVA. Results - Despite that both methods ranked individualsβ levels of biomarkers very similarly (Pearsonβs r all=0.755) absolute concentrations of all biomarkers differed significantly between methods. Equations retrieved by the Deming regression enabled proper realignment of the data to overcome these differences, such that intra-class correlation coefficients were then 0.996 (CRP), 0.711 (SAA), 0.895 (sICAM-1) and 0.858 (sVCAM-1). Additionally, individual biomarkers differed across categories of glucose metabolism, weight, metabolic syndrome and smoking status to a similar extent by either method. Conclusions - Multiple low-grade inflammatory biomarker data obtained by the 4-plex multi-array platform of MSD or by well-established single-biomarker methods are comparable after proper realignment of differences in absolute concentrations, and are equally associated with cardiovascular risk factors, regardless of such differences. Given its greater efficiency, the MSD platform is a potential tool for the quantification of multiple biomarkers of low-grade inflammation in large ongoing and future clinical studies
Sex disparities in cardiovascular risk factor assessment and screening for diabetes-related complications in individuals with diabetes: a systematic review
Background Insight in sex disparities in the detection of cardiovascular risk factors and diabetes-related complications may improve diabetes care. The aim of this systematic review is to study whether sex disparities exist in the assessment of cardiovascular risk factors and screening for diabetes-related complications.MethodsPubMed was systematically searched up to April 2020, followed by manual reference screening and citations checks (snowballing) using Google Scholar. Observational studies were included if they reported on the assessment of cardiovascular risk factors (HbA1c, lipids, blood pressure, smoking status, or BMI) and/or screening for nephropathy, retinopathy, or performance of feet examinations, in men and women with diabetes separately. Studies adjusting their analyses for at least age, or when age was considered as a covariable but left out from the final analyses for various reasons (i.e. backward selection), were included for qualitative analyses. No meta-analyses were planned because substantial heterogeneity between studies was expected. A modified Newcastle-Ottawa Quality Assessment Scale for cohort studies was used to assess risk of bias.ResultsOverall, 81 studies were included. The majority of the included studies were from Europe or North America (84%).The number of individuals per study ranged from 200 to 3,135,019 and data were extracted from various data sources in a variety of settings. Screening rates varied considerably across studies. For example, screening rates for retinopathy ranged from 13% to 90%, with half the studies reporting screening rates less than 50%. Mixed findings were found regarding the presence, magnitude, and direction of sex disparities with regard to the assessment of cardiovascular risk factors and screening for diabetes-related complications, with some evidence suggesting that women, compared with men, may be more likely to receive retinopathy screening and less likely to receive foot exams.ConclusionOverall, no consistent pattern favoring men or women was found with regard to the assessment of cardiovascular risk factors and screening for diabetes-related complications, and screening rates can be improved for both sexes.Public Health and primary carePrevention, Population and Disease management (PrePoD
Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: the Maastricht Study
Background Women with type 2 diabetes are disproportionally affected by macrovascular complications; we here investigated whether this is also the case for microvascular complications and retinal microvascular measures. Methods In a population-based cohort study of individuals aged 40-75 years (n = 3410; 49% women, 29% type 2 diabetes (oversampled by design)), we estimated sex-specific associations, and differences therein, of (pre)diabetes (reference: normal glucose metabolism), and of continuous measures of glycemia with microvascular complications and retinal measures (nephropathy, sensory neuropathy, and retinal arteriolar and venular diameters and dilatation). Sex differences were analyzed using regression models with interaction terms (i.e. sex-by- (pre)diabetes and sex-by-glycemia) and were adjusted for potential confounders. Results Men with type 2 diabetes (but not those with prediabetes) compared to men with normal glucose metabolism, (and men with higher levels of glycemia), had significantly higher prevalences of nephropathy (odds ratio: 1.58 95% CI (1.01;2.46)) and sensory neuropathy (odds ratio: 2.46 (1.67;3.63)), larger retinal arteriolar diameters (difference: 4.29 mu m (1.22;7.36)) and less retinal arteriolar dilatation (difference: - 0.74% (- 1.22; - 0.25)). In women, these associations were numerically in the same direction, but generally not statistically significant (odds ratios: 1.71 (0.90;3.25) and 1.22 (0.75;1.98); differences: 0.29 mu m (- 3.50;4.07) and: - 0.52% (- 1.11;0.08), respectively). Interaction analyses revealed no consistent pattern of sex differences in the associations of either prediabetes or type 2 diabetes or glycemia with microvascular complications or retinal measures. The prevalence of advanced-stage complications was too low for evaluation. Conclusions Our findings show that women with type 2 diabetes are not disproportionately affected by early microvascular complications.Prevention, Population and Disease management (PrePoD)Public Health and primary car
Caco-2 cells secrete two independent classes of lipoproteins with distinct density: effect of the ratio of unsaturated to saturated fatty acid
Polarized Caco-2 cells can synthesize two distinct density classes of lipoproteins, i.e. chylomicron/VLDL (d <1.006 g/ml) or IDL/LDL density (1.009 <d <1.068 g/ml). When saturated fatty acid in the incubation medium is replaced with unsaturated fatty acid, this results in an increase in the basolateral secretion of triglycerides from 18.6 +/- 3.6 nmol/filter (with 0.5 mmol/l 16:0) to 21.4 +/- 6.2, 27.5 +/- 4.8 and 28.9 +/- 5.3 nmol/filter when 10, 20 or 30% of 16:0 were substituted by 18:1. The secretion of IDL/LDL-sized lipoproteins diminished and chylomicron/VLDL secretion increased in proportion to the increase of unsaturated fatty acid in the medium. To gain insight into the relationship between these lipoprotein classes, we determined their secretion at several time intervals (0-4, 4-8 and 22-26 h) after incubation with a fatty acid mixture containing 16:0 and 18:1 in a 9:1 molar ratio (total fatty acid concentration was 0.5 mmol/l). Chylomicron/VLDL secretion was detectable immediately upon the start of the incubation and persisted during all intervals. In contrast, IDL/LDL density lipoproteins were first detectable in the 4-8 h time interval and their secretion was highest in the final phase of the incubation (22-26 h). We conclude that Caco-2 cells secrete two distinct density classes of lipoproteins that show no precursor-product relation
Genetic and environmental influences interact with age and sex in shaping the human methylome
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