International Course Landscape Architecture.

The Wageningen international course: some backgrounds on a twelf week cours

Use of phenobarbitone for treating childhood epilepsy in resource-poor countries

Should the continued use of phenobarbitone for childhood epilepsy in resource-poor countries be considered a form of discrimination? Phenobarbitone was recommended by the World Health Organization (WHO) as the first-line agent for the control of seizures,1 but this has been contested on the grounds that it is biased against resource-poor countries.2 It was first used as an anticonvulsant in 1912, but now has little role to play in First-World countries where the newer generation agents are readily accessible. Phenobarbitone monotherapy has equivalent efficacy to the newer anticonvulsants (phenytoin, sodium valproate and carbamazepine) in children with partial-onset and generalised tonic-clonic seizures.3 Phenobarbitone is cheap, readily available, and easy to use and store. However, it has definite cognitive and behavioural side-effects in many children. It can exacerbate seizures in about 35% of children, and extreme caution should be taken with children who have a pre-morbid state of behavioural problems or attention deficit hyperactivity disorder (ADHD)

CC's for the CIO - Core competencies for the chief information officer

The role of the modern-day Chief Information Officer (CIO) is multi-faceted, dynamic, inherently pressured and complex, and one which requires a multidisciplinary knowledge and skill-set. As the executive charged with the responsibility of managing the fast changing and complex Information Systems (IS) and Information Technology (IT) function, the modern-day CIO must possess and continually develop a wide range of diverse competencies. Today's CIO is required to take a much broader role in the business, drive business transformation, innovate for competitive advantage and act as a key strategic partner within the wider organisation. This study reports preliminary findings from 30 Australian CIOs on the identification of core competencies and is part of a larger body of work leading to the development of a CIO Competency Framework - for use by both practitioners and researchers to help bridge the gap between practice and theory and aid in CIO succession planning

Genderkloof in de wetenschap verdwijnt niet vanzelf

Een actieplan voor meer diversiteit in de wetenschap werd onlangs fors afgezwakt door de Tweede ­Kamer. Maar de argumenten ­waarmee dat gebeurde, zijn wankel, schrijven Michiel Kolman en ­Jojanneke van der Toorn.Social decision makin

Paradigmawisselingen en constanten: 200 jaar taalkundige diversiteit

Interne en externe geschiedenis van het Nederlands en zijn dialecte

Can AMP induce sputum eosinophils, even in subjects with complete asthma remission?

<p>Abstract</p> <p>Background</p> <p>The definition of <b>"</b>clinical asthma remission" is based on absence of symptoms and use of medication. However, in the majority of these subjects airway inflammation is still present when measured. In the present study we investigated whether "complete asthma remission", additionally defined by the absence of bronchial hyperresponsiveness (BHR) and the presence of a normal lung function, is associated with the absence of airway inflammation.</p> <p>Methods</p> <p>Patients with a former diagnosis of asthma and a positive histamine provocation test were re-examined to identify subjects with complete asthma remission (no asthma symptoms or medication, PC₂₀histamine > 32 mg/ml, FEV₁> 90% predicted). Patients with PC₂₀histamine ≤ 32 mg/ml were defined as current asthmatics and were divided in two groups, i.e. asthmatics with and without BHR to adenosine 5'monophoshate (AMP). Sputum induction was performed 1 week before and 1 hour after AMP provocation. Sputum induction and AMP provocation were previously shown to be sensitive markers of airway inflammation.</p> <p>Results</p> <p>Seven patients met criteria for complete asthma remission. Twenty-three were current asthmatics, including twelve without hyperresponsiveness to AMP. Subjects with complete asthma remission showed no AMP-induced sputum eosinophilia (median (range) 0.2 (0 - 4.6)% at baseline and 0.2 (0 - 2.6)% after AMP). After AMP, current asthmatics had a significant increase in sputum eosinophils (0.5 (0 - 26.0)% at baseline and 2.6 (0 - 32.0) % after AMP), as had the subgroup of current asthmatics without hyperresponsiveness to AMP (0.2 (0 - 1.8)% at baseline and 1.3 (0 - 6.3)% after AMP).</p> <p>Conclusions</p> <p>Subjects with complete asthma remission, in contrast to subjects with current asthma, do not respond with eosinophilic inflammation in sputum after AMP provocations. These data lend support to the usefulness of the definition of complete asthma remission.</p

Do high molecular weight adiponectin levels associate with radiographic progression in early rheumatiod arthritis and hand osteoarthritis?

Pathophysiology and treatment of rheumatic disease