210 research outputs found
Ground reaction forces during walking with different load and slope combinations in rats
BACKGROUND: Treadmill animal models are commonly used to study effects of exercise on bone. Since mechanical loading induces bone strain, resulting in bone formation, exercise that induces higher strains is likely to cause more bone formation. Our aim was to investigate the effect of slope and additional load on limb bone strain. METHODS: Horizontal and vertical ground reaction forces on left fore-limb (FL) and hind-limb (HL) of twenty 23-week old female Wistar rats (weight 279 ± 26 g) were measured for six combinations of SLOPE (-10°, 0°, +10°) and LOAD (0 to 23% of body mass). Peak force (Fmax), rate of force rise (RC), stance time (Tstance) and impulse (Fint) on FLs and HLs were analyzed. RESULTS: For the FL, peak ground reaction forces and rate of force rise were highest when walking downward -10° with load (Fmax = 2.09±0.05 N, FLRC = 34±2 N/s) For the HL, ground reaction forces and rate of force rise were highest when walking upward +10°, without load (Fmax = 2.20±0.05 N, HLRC = 34±1 N/s). Load increased stance time. Without additional load, estimates for the highest FL loading (slope is -10°) were larger than for the highest HL loading (slope is +10°) relative to level walking. CONCLUSIONS: Thus, walking downward has a higher impact on FL bones, while walking upward is a more optimal HL exercise. Additional load may have a small effect on FL loading
Direct magneto-optical compression of an effusive atomic beam for high-resolution focused ion beam application
An atomic rubidium beam formed in a 70 mm long two-dimensional
magneto-optical trap (2D MOT), directly loaded from a collimated Knudsen
source, is analyzed using laser-induced fluorescence. The longitudinal velocity
distribution, the transverse temperature and the flux of the atomic beam are
reported. The equivalent transverse reduced brightness of an ion beam with
similar properties as the atomic beam is calculated because the beam is
developed to be photoionized and applied in a focused ion beam. In a single
two-dimensional magneto-optical trapping step an equivalent transverse reduced
brightness of A/(m sr eV) was
achieved with a beam flux equivalent to nA. The
temperature of the beam is further reduced with an optical molasses after the
2D MOT. This increased the equivalent brightness to A/(m sr eV). For currents below 10 pA, for which disorder-induced
heating can be suppressed, this number is also a good estimate of the ion beam
brightness that can be expected. Such an ion beam brightness would be a six
times improvement over the liquid metal ion source and could improve the
resolution in focused ion beam nanofabrication.Comment: 10 pages, 8 figures, 1 tabl
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COVID-19 Outcomes in Minority Ethnic Groups: Do Obesity and Metabolic Risk Play a Role?
Purpose of Review
Globally, minority ethnic groups have been at higher risk of COVID-19 mortality and morbidity than majority populations. This review outlines factors that may interact to create these inequalities and explores the hypothesis that differing levels of cardio-metabolic risk, according to ethnic group, play a role.
Recent Findings
Two UK Biobank studies have reported that the body mass index is more strongly associated with an increased risk of COVID-19 infection and mortality in minority ethnic populations than in White populations. A study of UK patients found that the strongest association between obesity and adverse COVID-19 outcomes was in people of Black ethnicity.
Summary
Differences in the prevalence of obesity and its metabolic sequelae have been shown to partly mediate ethnic inequalities in COVID-19 outcomes, although not always consistently. It is possible that ethnic differences in the consequences of obesity may explain some of the remaining disparity in COVID-19 risk
Coherent Pair Production by Photons in the 20-170 GeV Energy Range Incident on Crystals and Birefringence
The cross section for coherent pair production by linearly polarised photons
in the 20-170 GeV energy range was measured for photon aligned incidence on
ultra-high quality diamond and germanium crystals. The theoretical description
of coherent bremsstrahlung and coherent pair production phenomena is an area of
active theoretical debate and development. However, under our experimental
conditions, the theory predicted the combined cross section and polarisation
experimental observables very well indeed. In macroscopic terms, our experiment
measured a birefringence effect in pair production in a crystal. This study of
this effect also constituted a measurement of the energy dependent linear
polarisation of photons produced by coherent bremsstrahlung in aligned
crystals. New technologies for manipulating high energy photon beams can be
realised based on an improved understanding of QED phenomena at these energies.
In particular, this experiment demonstrates an efficient new polarimetry
technique. The pair production measurements were done using two independent
methods simultaneously. The more complex method using a magnet spectrometer
showed that the simpler method using a multiplicity detector was also viable.Comment: 10 pages, 13 figures, 1 table, REVTeX4 two column, Version for
publicatio
Linear to Circular Polarisation Conversion using Birefringent Properties of Aligned Crystals for Multi-GeV Photons
We present the first experimental results on the use of a thick aligned Si
crystal acting as a quarter wave plate to induce a degree of circular
polarisation in a high energy linearly polarised photon beam. The linearly
polarised photon beam is produced from coherent bremsstrahlung radiation by 178
GeV unpolarised electrons incident on an aligned Si crystal, acting as a
radiator. The linear polarisation of the photon beam is characterised by
measuring the asymmetry in electron-positron pair production in a Ge crystal,
for different crystal orientations. The Ge crystal therefore acts as an
analyser. The birefringence phenomenon, which converts the linear polarisation
to circular polarisation, is observed by letting the linearly polarised photons
beam pass through a thick Si quarter wave plate crystal, and then measuring the
asymmetry in electron-positron pair production again for a selection of
relative angles between the crystallographic planes of the radiator, analyser
and quarter wave plate. The systematics of the difference between the measured
asymmetries with and without the quarter wave plate are predicted by theory to
reveal an evolution in the Stokes parameters from which the appearance of a
circularly polarised component in the photon beam can be demonstrated. The
measured magnitude of the circularly polarised component was consistent with
the theoretical predictions, and therefore is in indication of the existence of
the birefringence effect.Comment: 12 pages, 12 figures, 1 table, REVTeX4 two column, Version for
publicatio
Results on the Coherent Interaction of High Energy Electrons and Photons in Oriented Single Crystals
The CERN-NA-59 experiment examined a wide range of electromagnetic processes
for multi-GeV electrons and photons interacting with oriented single crystals.
The various types of crystals and their orientations were used for producing
photon beams and for converting and measuring their polarisation.
The radiation emitted by 178 GeV unpolarised electrons incident on a 1.5 cm
thick Si crystal oriented in the Coherent Bremsstrahlung (CB) and the
String-of-Strings (SOS) modes was used to obtain multi-GeV linearly polarised
photon beams.
A new crystal polarimetry technique was established for measuring the linear
polarisation of the photon beam. The polarimeter is based on the dependence of
the Coherent Pair Production (CPP) cross section in oriented single crystals on
the direction of the photon polarisation with respect to the crystal plane.
Both a 1 mm thick single crystal of Germanium and a 4 mm thick multi-tile set
of synthetic Diamond crystals were used as analyzers of the linear
polarisation.
A birefringence phenomenon, the conversion of the linear polarisation of the
photon beam into circular polarisation, was observed. This was achieved by
letting the linearly polarised photon beam pass through a 10 cm thick Silicon
single crystal that acted as a "quarter wave plate" (QWP) as suggested by N.
Cabibbo et al.Comment: Presented at International workshop "Relativistic Channeling and
Related Coherent Phenomena", Frascati (Rome) 23-26 March 200
Coherent bremsstrahlung, boherent pair production, birefringence and polarimetry in the 20-170 GeV energy range using aligned crystals
The processes of coherent bremsstrahlung (CB) and coherent pair production
(CPP) based on aligned crystal targets have been studied in the energy range
20-170 GeV. The experimental arrangement allowed for measurements of single
photon properties of these phenomena including their polarization dependences.
This is significant as the theoretical description of CB and CPP is an area of
active theoretical debate and development. With the theoretical approach used
in this paper both the measured cross sections and polarization observables are
predicted very well. This indicates a proper understanding of CB and CPP up to
energies of 170 GeV. Birefringence in CPP on aligned crystals is applied to
determine the polarization parameters in our measurements. New technologies for
high energy photon beam optics including phase plates and polarimeters for
linear and circular polarization are demonstrated in this experiment. Coherent
bremsstrahlung for the strings-on-strings (SOS) orientation yields a larger
enhancement for hard photons than CB for the channeling orientations of the
crystal. Our measurements and our calculations indicate low photon
polarizations for the high energy SOS photons.Comment: 23 pages, 27 figures, 2 tables, REVTeX4 two column
Histamine, a vasoactive agent with vascular disrupting potential, improves tumour response by enhancing local drug delivery
Tumour necrosis factor (TNF)-based isolated limb perfusion (ILP) is an approved and registered treatment for sarcomas confined to the limbs in Europe since 1998, with limb salvage indexes of 76%. TNF improves drug distribution in solid tumours and secondarily destroys the tumour-associated vasculature (TAV). Here we explore the synergistic antitumour effect of another vasoactive agent, histamine (Hi), in doxorubicin (DXR)-based ILP and evaluate its antivascular effects on TAV. We used our well-established rat ILP model for in vivo studies looking at tumour response, drug distribution and effects on tumour vessels. In vitro studies explored drug interactions at cellular level on tumour cells (BN-175) and Human umbilical vein endothelial cells (HUVEC). There was a 17% partial response and a 50% arrest in tumour growth when Hi was combined to DXR, without important side effects, against 100% progressive disease with DXR alone and 29% arrest in tumour growth for Hi alone. Histology documented an increased DXR leakage in tumour tissue combined to a destruction of the TAV, when Hi was added to the ILP. In vitro no synergy between the drugs was observed. In conclusion, Hi is a vasoactive drug, targeting primarily the TAV and synergises with different chemotherapeutic agents
Clinicopathological characteristics of resected adenosquamous cell carcinoma of the lung: Risk of coexistent double cancer
<p>Abstract</p> <p>Background</p> <p>adenosquamous carcinoma (ADSQ) of non-small cell lung cancer (NSCLC) is a rare disease and the biological behavior and clinicopathological characteristics have not yet been thoroughly described.</p> <p>Method</p> <p>This study reviewed the patient charts of 11 (1.6%) ADSQ cases among 779 patients with primary lung cancer who underwent a lung resection. The characteristics and clinicopathological factors were evaluated retrospectively.</p> <p>Results</p> <p>Six of the 11 patients with ADSQ were male and five were female. The mean age was 67.3 years' olds. Three patients had pathological stage IA, one patient each had stage IB and IIA, five patients had stage IIIA, and one patient stage IIIB. Five patients had coexistent double cancer including 2 gastric, 1 rectal, 1 prostate and 1 bladder cancer. ADSQ was found less frequently in males than squamous cell carcinoma (SQ). ADSQ was found more frequently in older patients, with advanced stage, advanced T status, and lymph node metastases than adenocarcinoma (AD). The proportion with coexistent double cancer of AD, SQ, and ADSQ were 21.1, 17.6, and 45.5%, respectively. ADSQ had a significantly correlation with double cancer (ADSQ vs. non- ADSQ p = 0.03). A multivariate analysis showed no significant prognostic difference between the patients with ADSQ and non- ADSQ.</p> <p>Conclusions</p> <p>In this study, cases with ADSQ showed no significantly prognostic difference in comparison to AD and SQ. However, surgeons must be cautious of any coexistent double cancer because approximately half of all patients with ADSQ of the lung have double cancer.</p
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