535 research outputs found
Reuleaux plasticity: improving Mohr-Coulomb and Drucker-Prager
The yielding of soil exhibits both a Lode angle dependency and a dependency on the intermediate principal stress. Ignoring these leads to a loss of realism in geotechnical analysis, yet neither of the widely used Mohr-Coulomb (M-C) or Drucker-Prager (D-P) models include both. This paper presents a simple pressure-dependent plasticity model based on a modified Reuleaux (mR) triangle which overcomes these limitations and yet (like the M-C and D-P formulations) allows for an analytical backward-Euler stress integration solution scheme. This latter feature is not found in more sophisticated (and computationally expensive) models. The mR deviatoric function is shown to provide a significantly improved fit to experimental data when compared with the M-C and D-P functions. Finite deformation finite-element analysis of the expansion of a cylindrical cavity is presented, verifying the use of the mR constitutive model for practical analyses
PMP22 related neuropathies: Charcot-Marie-Tooth disease type 1A and Hereditary Neuropathy with liability to Pressure Palsies
PMP22 related neuropathies comprise (1) PMP22 duplications leading to Charcot-Marie-Tooth disease type 1A (CMT1A), (2) PMP22 deletions, leading to Hereditary Neuropathy with liability to Pressure Palsies (HNPP), and (3) PMP22 point mutations, causing both phenotypes. Overall prevalence of CMT is usually reported as 1:2,500, epidemiological studies show that 20-64% of CMT patients carry the PMP22 duplication. The prevalence of HNPP is not well known. CMT1A usually presents in the first two decades with difficulty walking or running. Distal symmetrical muscle weakness and wasting and sensory loss is present, legs more frequently and more severely affected than arms. HNPP typically leads to episodic, painless, recurrent, focal motor and sensory peripheral neuropathy, preceded by minor compression on the affected nerve. Electrophysiological evaluation is needed to determine whether the polyneuropathy is demyelinating. Sonography of the nerves can be useful. Diagnosis is confirmed by finding respectively a PMP22 duplication, deletion or point mutation. Differential diagnosis includes other inherited neuropathies, and acquired polyneuropathies. The mode of inheritance is autosomal dominant and de novo mutations occur. Offspring of patients have a chance of 50% to inherit the mutation from their affected parent. Prenatal testing is possible; requests for prenatal testing are not common. Treatment is currently symptomatic and may include management by a rehabilitation physician, physiotherapist, occupational therapist and orthopaedic surgeon. Adult CMT1A patients show slow clinical progression of disease, which seems to reflect a process of normal ageing. Life expectancy is norma
Legacy effects of nitrogen and phosphorus additions on vegetation and carbon stocks of upland heaths
Open Access via the Wiley Jisc Agreement. Funding Information Scottish Natural Heritage Royal Society of Edinburgh Fellowship Scottish Government Rural and Environment Science and Analytical Services Division (RESAS) N8 AgriFoodPeer reviewedPublisher PD
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