Synthesis and Antimicrobial Activity of the Essential Oil Compounds (E)- and (Z)-3-Hexenyl Nonanoate and Two Analogues

The synthesis of (E)- and (Z)-3-hexenyl nonanoate, known constituents of essential oil containing plants, and two related compounds is reported. These compounds were assembled from nonanoyl chloride or nonanoic acid and the respective alcohols. In particular, it was found that the use of triethylamine as a co-solvent was necessary to avoid acid-mediated isomerization of the alkenes, which resulted in an inseparable mixture of products. The antimicrobial activity of the four hexenyl and hexyl nonanoate compounds was undertaken using microdilution minimum inhibitory concentration (MIC) analysis against eight test microorganisms. All four compounds demonstrated activity, with (E)-3-hexenyl nonanoate 1b having the highest inhibition (MIC value of 0.45 mg mL–1) against Pseudomonas aeruginosa ATCC 27858. Furthermore, this compound demonstrated the highest broad-spectrum activity (mean MIC value of 1.24 ± 0.50 mg mL–1) with noteworthy activity against all pathogens tested.Keywords: Essential oil constituent, (E)- and (Z)-3-hexenyl nonanoate, antimicrobial, ester synthesis, acid-induced alkene isomerizations PDF and supplemetary file attached.

The Synthesis of 5-, 6-, 7- and 8-Membered Oxygen-containing Benzo-fused Rings using Alkene Isomerization and Ring-closing Metathesis Reactions

A number of benzo-fused oxygen-containing heterocycles were synthesized from allyl-3-isopropoxy- 4-methoxybenzaldehyde using metathesis or an alkene isomerization-metathesis sequence as key synthetic steps. Benzo-fused compounds thus formed included a 3,6-dihydro-1H-2-benzoxocine, 1,3-dihydro- benzo[c]oxepine, 1H-isochromene, 2,3-dihydro-benzo[b]oxepine, benzofuran and 2H-chromene skeleton, demonstrating the versatility of this methodology.KEYWORDS: Ring-closing metathesis, isomerization, ruthenium, benzo-fused compounds

Synthesis of Novel Piperazine-linked Anthranilic Acids as Potential Small Molecule Kinase Inhibitors

Substituted anthranilic acid and piperazines were used as building blocks to prepare two libraries of  compounds, with the aim being that they would exhibit biochemical activity as small molecule kinase inhibitors. The synthesized anthranilamidepiperazine compounds were subsequently tested against a panel of kinases including EGFR, Abl, Akt and Aurora B.KEYWORDS: Small molecule kinase inhibitors, anthranilic acid, piperazines, EGFR

Selective derivatisation of resorcinarene ethers <i>via</i> an ortholithiation approach

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The Synthesis of Substituted Piperazine-cholesterol Conjugates for use as Components of Nucleic Acid Transfection Lipoplexes

A small library of cholesterol-piperazine conjugates were synthesized by the reaction of cholesteryl chloroformate with a set of substituted piperazines in dichloromethane at room temperature. The conjugates, all obtained in good to excellent yields, were synthesized to be key components of nucleic acid transfection lipoplexes.Keywords: Piperazine, Cholesterol, Conjugates, Transfection, Cationic Lipoplexe

Tubular shaped composites made from polythiophene covalently linked to Prato functionalized N-doped carbon nanotubes

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Nanocomposites of gold and poly(3-hexylthiophene) containing fullerene moieties: Synthesis, characterization and application in solar cells

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Synthesis and characterization of single wall carbon nanotube-grafted poly(3-hexylthiophene) and their nanocomposites with gold nanoparticles

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Synthesis of C-60-containing Polymers by Ring-opening Metathesis Co-polymerization of a C-60-cyclopentadiene Cycloadduct and N-(cycloheptyl)-endo-norbornene-5,6-dicarboximide and their Application in a Photovoltaic Device

A C-60-cyclopentadiene cycloadduct and N-(cycloheptyl)-endo-norbornene-5,6-dicarboximide were utilized as co-monomers in ring-opening metathesis polymerization (ROMP) reactions to afford a series of polymers containing C-60 in varying ratios. The polymerization reactions were catalyzed by the Grubbs second-generation ruthenium catalyst, and the co-polymers formed were investigated by spectroscopic and thermal techniques. The photovoltaic behavior of the new materials was studied by the construction of a simple sandwich-type photovoltaic cell. Under irradiation we concluded that the C-60 in the copolymers simultaneously accelerated both the charge separation in the polymer and the charge recombination between the electrons in the TiO2 and the electrolyte.213198212DST/NRF Centre of Excellence in Strong Materials,NRF [GUN 2053652]University of the Witwatersrand (University and Science Faculty Research Councils)NRF [GUN 2053652

Overcoming compound fluorescence in the FLiK screening assay with red-shifted fluorophores

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