Optimal extent of completion lymphadenectomy for patients with melanoma and a positive sentinel node in the groin

Background: The optimal extent of groin completion lymph node dissection (CLND) (inguinal or ilioinguinal dissection) in patients with melanoma is controversial. The aim of this study was to evaluate whether the extent of groin CLND after a positive sentinel node biopsy (SNB) is associated with improved outcome. Methods: Data from all sentinel node-positive patients who underwent gr

Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future

Purpose Age-related macular degeneration (AMD) is a frequent, complex disorder in elderly of European ancestry. Risk profiles and treatment options have changed considerably over the years, which may have affected disease prevalence and outcome. We determined the prevalence of early and late AMD in Europe from 1990 to 2013 using the European Eye Epidemiology (E3) consortium, and made projections for the future. Design Meta-analysis of prevalence data. Participants A total of 42 080 individuals 40 years of age and older participating in 14 population-based cohorts from 10 countries in Europe. Methods AMD was diagnosed based on fundus photographs using the Rotterdam Classification. Prevalence of early and late AMD was calculated using random-effects meta-analysis stratified for age, birth cohort, gender, geographic region, and time period of the study. Best-corrected visual acuity (BCVA) was compared between late AMD subtypes; geographic atrophy (GA) and choroidal neovascularization (CNV). Main Outcome Measures Prevalence of early and late AMD, BCVA, and number of AMD cases. Results Prevalence of early AMD increased from 3.5% (95% confidence interval [CI] 2.1%–5.0%) in those aged 55–59 years to 17.6% (95%

Social skills: A resource for more social support, lower depression levels, higher quality of life and participation in individuals with spinal cord injury?

Objective: to examine the relevance of social skills and their different dimensions (i.e. expressivity, sensitivity and control) in relation to social support, depression, participation and quality of life (QoL) in individuals with spinal cord injury (SCI).Design: cross-sectional data collection within Swiss Spinal Cord Injury Cohort (SwiSCI).Setting: community-based.Participants: a total of 503 individuals with SCI.Interventions: not applicable.Main Outcome Measures: depression, participation and QoL were measured using the Hospital Anxiety and Depression Scale (HADS), the Utrecht Scale for Evaluation of Rehabilitation-Participation (USER-Participation) and 5 selected items of the World Health Organization Quality of Life Scale (WHOQOL-BREF). The Social Skills Inventory (SSI), and the Social Support Questionnaire (SSQ6) were used to assess social skills (expressivity, sensitivity, control) and social support.Results: structural equation modeling was conducted. In model 1 (chi-square 27.81, df=19, p=.087, RMSEA=.033, 90% CI=.000–.052) social skills as a latent variable was related to social support (?=.31/R2=.10), depression (?=-.31/Total R2=.42) and QoL (?=.46/R2=.25). Social support partially mediated the effect of social skills on QoL (indirect effect: ?=.04, p=.02) but not on depression or participation. In model 2 (chi-square of 27.96, df=19, p=.084, RMSEA=.031, 90%CI=.000–.053) the social skills dimension expressivity showed a path coefficient of ?=.20 to social support and ?=.18 to QoL. Sensitivity showed a negative path coefficient to QoL (?=-.15) and control a path coefficient of ?=-.15 to depression and ?=.24 to QoL.Conclusions: social skills are a resource related to more social support, lower depression scores and higher QoL<br/

Le Nouveau journal de Strasbourg

17 novembre 19101910/11/17 (N439).Appartient à l’ensemble documentaire : BNUStr014Appartient à l’ensemble documentaire : BNUStr017Appartient à l’ensemble documentaire : Alsace

Optimal extent of completion lymphadenectomy for patients with melanoma and a positive sentinel node in the groin

Contains fulltext : 183979.pdf (Publisher’s version ) (Open Access

Strategies for mitigation of nitrogen environmental impact from swine production Estratégias para minimização do impacto ambiental do azoto em suinicultura

This work presents strategies that can be implemented in order to minimize the environmental impact of swine slurry on soil, water, and air. This reduction can be achieved through decrease in nitrogen excretion and ammonia emissions. The correct feed formulation according to animal requirements, the increase in diet digestibility and improvement in animal performance can reduce nitrogen excretion. The use of additives either in the diet or in the manure as well as some equipment rearrangements can reduce ammonia emission.<br>Neste trabalho são apresentadas estratégias que podem ser implementadas para minimizar o impacto ambiental dos efluentes da produção suína sobre o solo, a água e a atmosfera. Esta redução pode ser obtida com a excreção de azoto e a sua volatilização. A formulação mais ajustada às necessidades dos animais, o aumento da digestibilidade da dieta e a melhoria do desempenho dos animais podem reduzir a excreção de azoto. O uso de aditivos nas dietas ou nos dejectos e alterações nas instalações pode reduzir a volatilização da amónia