Geological resource management of the future: Drilling down the possibilities

Management of geological resources is based, ideally, on information on the quality and quantity of surface and subsurface litho-stratigraphical properties. Increasingly, these data become available for the offshore realm, though the integration into manageable and user-friendly applications is still at its infancy. Building on expertise from on-land data mining, we are now in the phase of creating 3D voxel models allowing for multi criteria resource volume calculations. The underlying data will be subdued to uncertainty modelling, a necessary step to produce data products with confidence limits. Anticipating on the dynamic nature of the marine environment, we aim at coupling the voxel model to environmental impact models to calculate resource depletion and regeneration, based on geological boundary conditions. In combination with anticipated impacts on fauna and flora, mining thresholds will be defined. All of the information is integrated into a decision support system for easy querying and online visualizations . The main aim is to provide long-term predictions on resource quantities to ensure future developments for the benefit of society and our future generations

Еволюція топоформанта -щина в слов’янських мовах та його рефлекси в реґіональній історичній ойконімії

У статті автор на широкому географічно-історичному тлі простежує еволюцію топоформанта -щина в слов'янській топонімії детально аналізує рефлекси цього суфікса в реґіональній історичній ойконімії на прикладі дев'яти назв (і 12-ти мікроойконімних варіантів) населених пунктів Галицької та Львівської земель Руського воєводства із подальшим встановленням їхньої етимологи.В статье автор на широком географическо-историческом фоне прослеживает эволюцию топонимического форманта -щина в славянской топонимии детально анализирует рефлексы этого суффикса в региональной исторической ойконимии на примере девяти названий (с 12-ю микроойконимными вариантами) населенных пунктов Галицкой и Львовской земель Русского воеводства с последующим установлением их этимологии.The author traces the evolution of topoformant -schyna on the basis of historical and geographical studies in Slavic Toponymy. Reflexes of the suffix are analyzed in regional historical oykonymy in 12 toponyms (and their 12 microokonymic variants) of villages and towns of Halych and Lviv Lands of Ruske Woyewodstwo. Their etymology is also analysed

Recent Change—North Sea

This chapter discusses past and ongoing change in the following physical variables within the North Sea: temperature, salinity and stratification; currents and circulation; mean sea level; and extreme sea levels. Also considered are carbon dioxide; pH and nutrients; oxygen; suspended particulate matter and turbidity; coastal erosion, sedimentation and morphology; and sea ice. The distinctive character of the Wadden Sea is addressed, with a particular focus on nutrients and sediments. This chapter covers the past 200 years and focuses on the historical development of evidence (measurements, process understanding and models), the form, duration and accuracy of the evidence available, and what the evidence shows in terms of the state and trends in the respective variables. Much work has focused on detecting long-term change in the North Sea region, either from measurements or with models. Attempts to attribute such changes to, for example, anthropogenic forcing are still missing for the North Sea. Studies are urgently needed to assess consistency between observed changes and current expectations, in order to increase the level of confidence in projections of expected future conditions

Approach for Predicting Production Scenarios Focused on Cross Impact Analysis

AbstractOne of the most consistent challenges in business is anticipating what the future holds and what impact it may have on current production systems. The scenario technique is a well-established method for developing and forecasting multiple future development paths for companies. However, this method is mostly employed to develop and to support strategic long-term decisions. The core idea of the approach introduced in this paper is to convey the future impact of today's decisions on production systems to employees involved in production planning processes. With the help of immersive visualization, performed in virtual reality (VR) systems, planning participants can perceive how the factory must adapt to fit future demands.In this paper, the focus is on the fourth phase of the scenario technique – so called scenario development – and, in particular, the cross impact analysis. With this methodology, the interrelations, or cross impacts of the different basic elements are determined. The cross impact analysis results serve as a basis for the development of a standardized tool that can be used to create probable production scenarios out of given production systems. This standardized tool will facilitate the usage of the scenario technique for factory planning projects, as it focuses the immense diversity of future uncertainties companies are faced with on the factory level

IFNβ Protects Neurons from Damage in a Murine Model of HIV-1 Associated Brain Injury.

Infection with human immunodeficiency virus-1 (HIV-1) causes brain injury. Type I interferons (IFNα/β) are critical mediators of any anti-viral immune response and IFNβ has been implicated in the temporary control of lentiviral infection in the brain. Here we show that transgenic mice expressing HIV-1 envelope glycoprotein 120 in their central nervous system (HIVgp120tg) mount a transient IFNβ response and provide evidence that IFNβ confers neuronal protection against HIVgp120 toxicity. In cerebrocortical cell cultures, neuroprotection by IFNβ against gp120 toxicity is dependent on IFNα receptor 1 (IFNAR1) and the β-chemokine CCL4, as IFNAR1 deficiency and neutralizing antibodies against CCL4, respectively, abolish the neuroprotective effects. We find in vivo that IFNβ mRNA is significantly increased in HIVgp120tg brains at 1.5, but not 3 or 6 months of age. However, a four-week intranasal IFNβ treatment of HIVgp120tg mice starting at 3.5 months of age increases expression of CCL4 and concomitantly protects neuronal dendrites and pre-synaptic terminals in cortex and hippocampus from gp120-induced damage. Moreover, in vivo and in vitro data suggests astrocytes are a major source of IFNβ-induced CCL4. Altogether, our results suggest exogenous IFNβ as a neuroprotective factor that has potential to ameliorate in vivo HIVgp120-induced brain injury