24 research outputs found

    ReSolVe project – Restoring optimal Soil functionality in degraded areas within organic Vineyards

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    In both conventional and organic European vineyards, it is quite common to have areas characterized by problems in vine health, grape production and quality. These problems are very often related to sub-optimal soil functionality, caused by an improper land preparation before vine plantation and/or management. Different causes for soil malfunctioning can include: poor organic matter content and plant nutrient availability (both major and trace elements); imbalance of some element ratios (Ca/Mg, K/Mg, P/Fe, and Fe/Mn); pH; water deficiency; soil compaction and/or scarce oxygenation. Fertility related problems can often be compensated in conventional settings with externally introduced fertilizers that are not permitted in organic vineyards. ReSolVe is a transnational and multidisciplinary research project aimed at testing the effects of selected agronomic strategies for restoring optimal soil functionality in degraded areas within organic vineyard. The term "degraded areas within vineyard" means areas showing reduced vine growth, disease resistance, grape yield and quality. These areas may have lost their soil functionality because of either an improper land preparation, or an excessive loss of soil organic matter and nutrients, erosion and/or compaction. The project, financed by Core-Organic plus program of the ERA-NET plus action (2015-2018), aims at identifying the main causes of the soil functionality loss and testing different organic recovering methods. The different restoring strategies will implement: i) compost, ii) green manure with winter legumes, iii) dry mulching with cover crops. The strategies will be tested according to their efficiency to improve: i) plant and roots growth and well-being; ii) grape yield and quality; iii) quality of soil ecosystem services and their stability over the years; iv) better express of the “terroir effect”, that is, the linkage of wine quality to the environmental characteristics of the cultivation site. The project involves 8 research groups in 6 different EU countries (Italy, France, Spain, Sweden, Slovenia, and Turkey), with experts from several disciplines, including soil science, ecology, microbiology, grapevine physiology, viticulture, and biometry. The experimental vineyards are situated in Italy (Chianti hills and Maremma plain, Tuscany), France (Bordeaux and Languedoc), Spain (La Rioja) and Slovenia (Primorska) for winegrape, and in Turkey (Adana and Mersin) for table grape. The restoration techniques and the monitoring methodologies developed and tested during the ReSolVe project will be described in specific final guidelines. The restoration techniques will be accessible for all the European farmers and will be low cost and environmental-friendly. A protocol of analyses and measurements between the all partners will allow an effective and comparable monitoring of vineyard ecosystemic functioning in European countries

    Liver Fibrosis and Metabolic Alterations in Adults With alpha-1-antitrypsin Deficiency Caused by the Pi*ZZ Mutation

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    BACKGROUND & AIMS: Alpha-1 antitrypsin deficiency (AATD) is among the most common genetic disorders. Severe AATD is caused by a homozygous mutation in the SERPINA1 gene that encodes the Glu342Lys substitution (called the Pi*Z mutation, Pi*ZZ genotype). Pi*ZZ carriers may develop lung and liver diseases. Mutation- associated lung disorders have been well studied, but less is known about the effects in liver. We assessed the liver disease burden and associated features in adults with this form of AATD. METHODS: We collected data from 554 Pi*ZZ adults (403 in an exploratory cohort, 151 in a confirmatory cohort), in 9 European countries, with AATD who were homozygous for the Pi*Z mutation, and 234 adults without the Pi*Z mutation (controls), all without pre-existing liver disease. We collected data on demographic parameters, comorbidities, lung- and liver-related health, and blood samples for laboratory analysis. Liver fibrosis was assessed non-invasively via the serum tests Aspartate Aminotransferase to Platelet Ratio Index and HepaScore and via transient elastography. Liver steatosis was determined via transient elastography-based controlled attenuation parameter. We performed histologic analyses of livers from transgenic mice that overexpress the AATD-associated Pi*Z variant. RESULTS: Serum levels of liver enzymes were significantly higher in Pi*ZZ carriers vs controls. Based on non-invasive tests for liver fibrosis, significant fibrosis was suspected in 20%–36% of Pi*ZZ carriers, whereas signs of advanced fibrosis were 9- to 20-fold more common in Pi*ZZ carriers compared to non-carriers. Male sex; age older than 50 years; increased levels of alanine aminotransferase, aspartate aminotransferase, or g-glutamyl transferase; and low numbers of platelets were associated with higher liver fibrosis burden. We did not find evidence for a relationship between lung function and liver fibrosis. Controlled attenuation parameter 280 dB/m, suggesting severe steatosis, was detected in 39% of Pi*ZZ carriers vs 31% of controls. Carriers of Pi*ZZ had lower serum concentrations of triglyceride and low- and very-lowdensity lipoprotein cholesterol than controls, suggesting impaired hepatic secretion of lipid. Livers from Pi*Zoverexpressing mice had steatosis and down-regulation of genes involved in lipid secretion. CONCLUSIONS: In studies of AATD adults with the Pi*ZZ mutation, and of Pi*Z-overexpressing mice, we found evidence of liver steatosisinfo:eu-repo/semantics/publishedVersio

    Hepatitis C diagnosics: clinical evaluation of the HCV-core antigen determination

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    Anti-VEGF Therapie im Bereich des vorderen Augenabschnitts

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