The crystal and molecular structure of 2,7-diazanaphthalene

X-ray diffraction data were collected at 20°C on a computer-controlled Philips diffractometer (PW 1100). The structure was solved by direct methods and refined by the full-matrix least-squares method to an R of 0.065 (weighted R 0.046). The molecule in the crystal is of lower symmetry than C2,.. The geometry of the molecule has been compared with NMR results obtained by Danieli, Lunazzi & Veracini [J. Chem. Soc. Perkin II, (1976), pp. 19-201. As a result a C-H bond-length correction of 0.09 (2) A was found

Overview geotechnical model tests on dike safety at Deltares

Three on-going dike safety studies (on: macro stability, piping and flow slides) in the Netherlands make use of geotechnical physical models. A short outline of these projects is presented; the physical models chosen are described and discussed. The three studies use different physical models, depending on the research questions at the beginning of the model test series, the heterogeneity that is anticipated in the field, the scaling laws and the knowledge level. The paper describes why a certain model was chosen

Trends in Computer Network Modeling Towards the Future Internet

This article provides a taxonomy of current and past network modeling efforts. In all these efforts over the last few years we see a trend towards not only describing the network, but connected devices as well. This is especially current given the many Future Internet projects, which are combining different models, and resources in order to provide complete virtual infrastructures to users. An important mechanism for managing complexity is the creation of an abstract model, a step which has been undertaken in computer networks too. The fact that more and more devices are network capable, coupled with increasing popularity of the Internet, has made computer networks an important focus area for modeling. The large number of connected devices creates an increasing complexity which must be harnessed to keep the networks functioning. Over the years many different models for computer networks have been proposed, and used for different purposes. While for some time the community has moved away from the need of full topology exchange, this requirement resurfaced for optical networks. Subsequently, research on topology descriptions has seen a rise in the last few years. Many different models have been created and published, yet there is no publication that shows an overview of the different approaches.

The moderate drift towards less tetracycline-susceptible isolates of contagious agalactia causative agents might result from different molecular mechanisms.

©2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in Veterinary Microbiology. To access the final edited and published work see https://doi.org/10.1016/j.vetmic.2018.05.001Contagious agalactia is a mycoplasmosis that affects small ruminants, is associated with loss of milk production and high morbidity rates, and is highly deleterious to dairy industries. The etiological agents are four mycoplasma (sub)species, of which the relative importance depends on the countries and the animal host. Tetracyclines are non 23 expensive, broad-spectrum antimicrobials and are often used to control mastitis in dairy herds. However, the in vitro efficiency of tetracyclines against each of the etiological agents of contagious agalactia has been poorly assessed. The aims of this study were i) to compare the tetracycline susceptibilities of various field isolates, belonging to different mycoplasma (sub)species and subtypes, collected over the years from different clinical contexts in France or Spain, and ii) to investigate the molecular mechanisms behind the decreased susceptibility of some isolates to tetracyclines. The Minimum Inhibitory Concentrations (MICs) of tetracyclines were determined in vitro on a set of 120 isolates. Statistical analyses were run to define the significance of any observed differences in MICs distribution. As mutations in the genes encoding the ttracycline targets (rrs loci) are most often associated with increased tetracycline MICs in animal mycoplasmas, these genes were sequenced. The loss of susceptibility to tetracyclines after year 2010 is not significant and recent MICs are higher in M. agalactiae, especially isolates from ovine mastitis cases, than in other etiological agents of contagious agalactia. The observed increases in MICs were not always associated with mutations in the rrs alleles which suggests the existence of other resistance mechanisms yet to be decipher

A distributed topology information system for optical networks based on the semantic web

The research networking community has embraced novel network architectures to provide e-Science applications with dedicated connections instead of shared links. IP and optical services converge in these new infrastructures to form hybrid networks. Lightpaths are the services offered to clients in the optical portion of the network. They are chosen because they guarantee the appropriate QoS in terms of bandwidth and latency. NDL-the Network Description Language-is a data model offering users and providers of lightpaths with a common ontology to describe topology information of hybrid optical networks. The strength of NDL is that it supports a wide range of applications, including pathfinding, visualisation and asset management, via the definition of a common data model to exchange network descriptions. Since NDL is based on the Semantic Web techniques, it is straightforward to relate NDL with application-specific ontologies. In this paper we present the current status of the NDL schemas and its use in several applications