Adiabatic Quantum Computing for Multi Object Tracking

Multi-Object Tracking (MOT) is most often approached in the tracking-by-detection paradigm, where object detections are associated through time. The association step naturally leads to discrete optimization problems. As these optimization problems are often NP-hard, they can only be solved exactly for small instances on current hardware. Adiabatic quantum computing (AQC) offers a solution for this, as it has the potential to provide a considerable speedup on a range of NP-hard optimization problems in the near future. However, current MOT formulations are unsuitable for quantum computing due to their scaling properties. In this work, we therefore propose the first MOT formulation designed to be solved with AQC. We employ an Ising model that represents the quantum mechanical system implemented on the AQC. We show that our approach is competitive compared with state-of-the-art optimization-based approaches, even when using of-the-shelf integer programming solvers. Finally, we demonstrate that our MOT problem is already solvable on the current generation of real quantum computers for small examples, and analyze the properties of the measured solutions

Melatonin treatment in children with therapy-resistant monosymptomatic nocturnal enuresis

Objective: To evaluate the effects of exogenous melatonin on the frequency of wet nights, on the sleep-wake cycle, and on the melatonin profile in children with therapy-resistant MNE. Patients and methods: 24 patients were included. Patients had to maintain a diary including time of sleep and arousal, and whether they had a dry or a wet bed in the morning. We measured baseline melatonin profiles in saliva. Hereafter, patients were randomized to synthetic melatonin or placebo. After 3 and 6 months we evaluated the frequency of enuresis and the melatonin profiles. Results: 11 patients were randomized to melatonin, 13 to placebo. We evaluated melatonin profiles of 7 patients in the melatonin group and of 8 in the placebo group. We observed a change in profile in the melatonin group, but we did not observe a difference in the sleep-wake cycle or the frequency of wet nights in either group. Conclusion: This is the first time exogenous melatonin has been evaluated in the treatment of MNE. Although we observed a change in melatonin profile after the use of exogenous melatonin, we did not observe a change in enuresis frequency or in the sleep-wake cycle of this select group of patients. (C) 2011 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved

Semantic-Context-Based Augmented Descriptor For Image Feature Matching

Abstract. This paper proposes an augmented version of local features that enhances the discriminative power of the feature without affecting its invariance to image deformations. The idea is about learning local features, aiming to estimate its semantic, which is then exploited in conjunction with the bag of words paradigm to build an augmented feature descriptor. Basically, any local descriptor can be casted in the proposed context, and thus the approach can be easy generalized to fit in with any local approach. The semantic-context signature is a 2D histogram which accumulates the spatial distribution of the visual words around each local feature. The obtained semantic-context component is concatenated with the local feature to generate our proposed feature descriptor. This is expected to handle ambiguities occurring in images with multiple similar motifs and depicting slight complicated non-affine distortions, outliers, and detector errors. The approach is evaluated for two data sets. The first one is intentionally selected with images containing multiple similar regions and depicting slight non-affine distortions. The second is the standard data set of Mikolajczyk. The evaluation results showed our approach performs significantly better than expected results as well as in comparison with other methods.

Effects of treadmill versus overground soccer match simulations on biomechanical markers of anterior cruciate ligament injury risk in side cutting.

Abstract This study aimed to investigate whether treadmill versus overground soccer match simulations have similar effects on knee joint mechanics during side cutting. Nineteen male recreational soccer players completed a 45-min treadmill and overground match simulation. Heart rate (HR) and rating of perceived exertion (RPE) were recorded every 5 min. Prior to exercise (time 0 min), at "half-time" (time 45 min) and 15 min post-exercise (time 60 min), participants performed five trials of 45° side-cutting manoeuvres. Knee abduction moments and knee extension angles were analysed using two-way repeated measures analysis of variance (α = 0.05). Physiological responses were significantly greater during the overground (HR 160 ± 7 beats ∙ min(-1); RPE 15 ± 2) than the treadmill simulation (HR 142 ± 5 beats ∙ min(-1); RPE 12 ± 2). Knee extension angles significantly increased over time and were more extended at time 60 min compared with time 0 min and time 45 min. No significant differences in knee abduction moments were observed. Although knee abduction moments were not altered over time during both simulations, passive rest during half-time induced changes in knee angles that may have implications for anterior cruciate ligament injury risk

The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complex

Transcription-coupled repair (TCR), a subpathway of nucleotide excision repair (NER) defective in Cockayne syndrome A and B (CSA and CSB), is responsible for the preferential removal of DNA lesions from the transcribed strand of active genes, permitting rapid resumption of blocked transcription. Here we demonstrate by microinjection of antibodies against CSB and CSA gene products into living primary fibroblasts, that both proteins are required for TCR and for recovery of RNA synthesis after UV damage in vivo but not for basal transcription itself. Furthermore, immunodepletion showed that CSB is not required for in vitro NER or transcription. Its central role in TCR suggests that CSB interacts with other repair and transcription proteins. Gel filtration of repair- and transcription-competent whole cell extracts provided evidence that CSB and CSA are part of large complexes of different sizes. Unexpectedly, there was no detectable association of CSB with several candidate NER and transcription proteins. However, a minor but significant portion (10-15%) of RNA polymerase II was found to be tightly associated with CSB. We conclude that within cell-free extracts, CSB is not stably associated with the majority of core NER or transcription components, but is part of a distinct complex involving RNA polymerase II. These findings suggest that CSB is implicated in, but not essential for, transcription, and support the idea that Cockayne syndrome is due to a combined repair and transcription deficiency

A simple and fast method to exclude high Plasmodium falciparum parasitaemia in travellers with imported malaria

Background: Counts of malaria parasites in peripheral blood are important to assess severity of Plasmodium falciparum malaria. Thin and thick smears are routinely used for this purpose. Methods. In this study the Binax NOW® Malaria Test, an easy-to-perform rapid diagnostic test, with Histidine Rich Protein-2 (HRP-2) and aldolase as diagnostic markers, was used for semi-quantitative assessment of parasitaemia of P. faciparum. Results: In 257 patients with imported P. falciparum malaria, reactivity of aldolase increased with higher parasitaemia. In all patients with a parasitaemia above 50,000 asexual parasites/l (> 1%) co-reactivity of HRP-2 and aldolase was observed. Absence of aldolase reactivity in the presence of HRP-2 was a reliable predictive marker to exclude high (> 1%) parasitaemia in P. falciparum malaria. Conclusions: Assessment of HRP-2 and aldolase co-reactivity can be of help in clinical decision making in the acute care setting of returning travellers suspected of having malaria