Report No. 28: Review of Methodologies Applied for the Assessment of Employment and Social Impacts

Joint report with ECORYS Netherlands for the DG Employment, Social Affairs and Equal Opportunities of the European Commission, Bonn 2010 (217 pages)

Annotation of the M. tuberculosis Hypothetical Orfeome: Adding Functional Information to More than Half of the Uncharacterized Proteins

The genome of Mycobacterium tuberculosis (H37Rv) contains 4,019 protein coding genes, of which more than thousand have been categorized as ‘hypothetical’ implying that for these not even weak functional associations could be identified so far. We here predict reliable functional indications for half of this large hypothetical orfeome: 497 genes can be annotated based on orthology, and another 125 can be linked to interacting proteins via integrated genomic context analysis and literature mining. The assignments include newly identified clusters of interacting proteins, hypothetical genes that are associated to well known pathways and putative disease-relevant targets. All together, we have raised the fraction of the proteome with at least some functional annotation to 88% which should considerably enhance the interpretation of large-scale experiments targeting this medically important organism

What is the <em>p</em>-factor of psychopathology? Some risks of general factor modeling

Recent research has suggested that a range of psychological disorders may stem from a single underlying common factor, which has been dubbed the p-factor. This finding may spur a line of research in psychopathology very similar to the history of factor modeling in intelligence and, more recently, personality research, in which similar general factors have been proposed. We point out some of the risks of modeling and interpreting general factors, derived from the fields of intelligence and personality research. We argue that: (a) factor-analytic resolution, i.e., convergence of the literature on a particular factor structure, should not be expected in the presence of multiple highly similar models; and (b) the true underlying model may not be a factor model at all, because alternative explanations can account for the correlational structure of psychopathology

Thiazinamium methysulfaat. Een onderzoek naar de farmacodynamiek en de klinische toepassing bij chronische gegeneraliseerde obstructieve longaandoeningen.

De aanleiding tot het onderzoek, waarvan in dit proefschrift verslag wordt gedaan, was een onzekerheid, ondanks veelvuldig gebruik, omtrent het bronchusverwijdend effect van orale toediening van thiazinamium methylsulfaat (th.ms. Multergan@). Deze twijfel kon blijven bestaan t.g.v. onvoldoende bekendheid met de resorptie, het metabolisme, het transport en de werking van dit anticholinergicum met antihistaminewerking.Het doel van het onderzoek was de kennis hieromtrent te verdiepen door de werking op de longfunctie en hartfrequentie te meten en met behulp van de bepalingsmethodiek en de kennis van de farmacokinetiek (Jonkman 1977) te verklaren. ... Zie: Samenvatting, discussie en slotconclusie