Paediatric chronic kidney disease

Doctors use various guidelines on paediatric chronic kidney disease (CKD) for managing their patients according to the availability of resources. As with adolescent and adult patients, CKD in children can also progress to end-stage renal failure – the time course being influenced by several modifiable factors. Decline in renal failure is best categorised in stages, which determine management and prognosis. Staging is based on three categories, i.e. cause, glomerular filtration rate and proteinuria. Early diagnosis of CKD allows for the institution of renoprotective treatment of modifiable factors and treatment to prevent the development of complications. The two most important modifiable factors that can be treated successfully are hypertension and proteinuria. The objective of this article is to provide information on the diagnosis and treatment of CKD in children. Early identification and treatment of modifiable risk factors of CKD decreases the burden of disease and delays or prevents the need for renal replacement therapy

Paediatric chronic kidney disease

Doctors use various guidelines on paediatric chronic kidney disease (CKD) for managing their patients according to the availability ofresources. As with adolescent and adult patients, CKD in children can also progress to end-stage renal failure – the time course beinginfluenced by several modifiable factors. Decline in renal failure is best categorised in stages, which determine management and prognosis.Staging is based on three categories, i.e. cause, glomerular filtration rate and proteinuria. Early diagnosis of CKD allows for the institutionof renoprotective treatment of modifiable factors and treatment to prevent the development of complications. The two most importantmodifiable factors that can be treated successfully are hypertension and proteinuria.The objective of this article is to provide information on the diagnosis and treatment of CKD in children. Early identification andtreatment of modifiable risk factors of CKD decreases the burden of disease and delays or prevents the need for renal replacement therapy

Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials

OBJECTIVES : Novel chemical tools to eliminate malaria should ideally target both the asexual parasites and transmissible gametocytes. Several imidazopyridazines (IMPs) and 2-aminopyridines (2-APs) have been described as potent antimalarial candidates targeting lipid kinases. However, these have not been extensively explored for stage-specific inhibition of gametocytes in Plasmodium falciparum parasites. Here we provide an in-depth evaluation of the gametocytocidal activity of compounds from these chemotypes and identify novel starting points for dual-acting antimalarials. METHODS : We evaluated compounds against P. falciparum gametocytes using several assay platforms for cross-validation and stringently identified hits that were further profiled for stage specificity, speed of action and ex vivo efficacy. Physicochemical feature extraction and chemogenomic fingerprinting were applied to explore the kinase inhibition susceptibility profile. RESULTS : We identified 34 compounds with submicromolar activity against late stage gametocytes, validated across several assay platforms. Of these, 12 were potent at 1000-fold selectivity towards the parasite over mammalian cells. Front-runner compounds targeted mature gametocytes within 48 h and blocked transmission to mosquitoes. The resultant chemogenomic fingerprint of parasites treated with the lead compounds revealed the importance of targeting kinases in asexual parasites and gametocytes. CONCLUSIONS : This study encompasses an in-depth evaluation of the kinase inhibitor space for gametocytocidal activity. Potent lead compounds have enticing dual activities and highlight the importance of targeting the kinase superfamily in malaria elimination strategies.The South African Medical Research Council (SAMRC) Self-initiated Research (to JN) and Strategic Health Initiatives Partnerships (MRC-SHIP) programmes to L.B., T.C., D.M. K.C. further acknowledges the SAMRC for funding of the extramural Drug Discovery and Development Research Unit at UCT. The SAMRC is acknowledged for funding of the UP ISMC (LMB) and WRIM (TLC) as Collaborating Centres for Malaria Research. The Council for Scientific and Industrial Research and the 3R Foundation (project 118–10) to D.M. We thank the Medicines for Malaria Venture and South African Technology Innovation Agency (TIA) for funding to K.C. (Project MMV09/0002). The University of Cape Town, University of Pretoria, and South African Research Chairs Initiative of the Department of Science and Technology, administered through the South African National Research Foundation are gratefully acknowledged for support to K.C. and L.B. (UID84627). JN was supported through an International Society for Infectious Diseases grant.https://academic.oup.com/jac2019-05-01hj2018Biochemistr

Die opleiding van bedryfsielkundiges aan die Univeristeit van Stellenbosch

The original publication is available at http://www.sajip.co.zaDie aanbieding van Bedryfsielkunde aan die Universiteit van Stellenbosch gaan sover terug as 1943 toe daar binne die Departement Sielkunde met 'n afsonderlike kursus in Bedryfsielkunde vir B.Comm.-studente 'n begin gemaak is. Hierdie kursus is in 1949 uitgebrei tot die derde jaar, toe dit moontlik geword het om 'n B.Comm.-graad met Bedryfsielkunde as een van die hoofvakke te behaal.Publishers' Versio

Akademiese vordering van studente aan die universiteit : 'n opvolgstudie

Proefskrif (M.Ed.) -- Universiteit van Stellenbosch, 1958.Full text to be digitised and attached to bibliographic record

Die emosionele spanning en labiliteit van die psigotiese pasient

Thesis (D. Phil.) -- University of Stellenbosch, 1953.Full text to be digitised and attached to bibliographic record

Die opleiding van bedryfsielkundiges aan die universiteit van Stellenbosch.

Die aanbieding van Bedryfsielkunde aan die Universiteit van Stellenbosch gaan sover terug as 1943 toe daar binne die Departement Sielkunde met 'n afsonderlike kursus in Bedryfsielkunde vir B.Comm.-studente 'n begin gemaak is. Hierdie kursus is in 1949 uitgebrei tot die derde jaar, toe dit moontlik geword het om 'n B.Comm.-graad met Bedryfsielkunde as een van die hoofvakke te behaal