Challenges and solutions for autism in academic geosciences

Researcher diversity promotes research excellence. But academia is widely perceived as inaccessible to those who work in non-stereotypical ways, and disabled researchers are consequently chronically under-represented within higher education. The barriers that academia presents to the inclusion and success of disabled individuals must therefore be understood and removed in order to enhance researcher diversity and improve the quality and quantity of research. Autism is a disability that is particularly under-represented within higher education, despite many autistic individuals having attributes that are conducive to research excellence. With a focus on geosciences, we use the experiences of an autistic PhD student to evaluate why academia can be inaccessible, and propose simple strategies that can reduce and remove barriers to academic success. We suggest that minor changes to communication, the academic environment and better disability awareness can make significant differences to the inclusion of disabled researchers, particularly those with autism. These changes would also benefit the wider scientific community and promote research and teaching excellence

Researching Hard-to Reach Populations: Privileged Access Interviewers and Drug Using Parents

Accessing drug using populations is notoriously fraught with difficulties for researchers (Gurdin & Patterson, 1987; Griffiths, Gosspo & Strang, 1993; Renzetti & Lee, 1993; Spreen & Zwaagstra, 1994; Goode, 2000; Elliott et al., 2002). These difficulties are the result of a number of reasons. The main one being that drug use is often illicit and/or illegal which often leads to the stigmatization of drug users within the media and elsewhere and this may ultimately lead to their lives being 'concealed by a veil of ignorance' (Elliott et al., 2002: 172). When one adds to this the fact that the population in question may have even more reason to remain hidden, for example, that they are drug using parents who may wish to conceal their identity as either parent or as drug user, accessing them may be even more complicated for researchers, service providers and policy makers alike.Privileged Access Interviewers, Drug Using Parents

The potential impact of the labour relations act 66 of 1995 on organised labour and labour organisation in the Western Cape agricultural sector

This dissertation looks at the history of farmworker organisation on farms in the Western Cape, and factors which have played a role in the demise and the growth of the union movement in the last few decades. In particular it focuses on the role which legislation has played, and will play, in influencing trade union activity in this sector. The new Labour Relations Act 66 of 1995 (hereinafter referred to as the LRA) affords farmworkers a host of new rights, which are inevitably going to impact upon labour relations on farms. The dissertation looks critically at this legislation, and whether or not the underlying aims of the act are capable of being adequately realised in the agricultural sector. The LRA provides a number of opportunities for trade unions, which agricultural unions may struggle to access. The suggestion in this dissertation is that farmworker trade unions are going to have to operate more strategically in this sector, if they hope to achieve maximum benefit from the LRA for their members. Possible strategies for fannworker unions are discussed in this dissertation, which may make it easier for unions to advance the interests of their members, and make a greater impact in certain sectors within agriculture. Unfortunately however, not all workers in agriculture are going to benefit from organisation, in light of the peculiar difficulties which rural organisations experience in accessing fanns. The LRA strongly favours workers who are unionised, and the result is that non-unionised workers are going to he severely prejudiced if they do not have access to trade unions. The dissertation looks at initiatives in the rural sectors which have emerged to ensure that agricultural workers are not left out in the cold as a result of the union-bias of the legislation

Effect of left atrial and ventricular abnormalities on renal transplant recipient outcome—a single-center study

Background: Premature cardiovascular (CV) death is the commonest cause of death in renal transplant recipients. Abnormalities of left ventricular (LV) structure (collectively termed uremic cardiomyopathy) and left atrial (LA) dilation, a marker of fluid status and diastolic function, are risk factors for reduced survival in patients with end stage renal disease (ESRD). In the present analysis, we studied the impact of pre-transplant LA and LV abnormalities on survival after successful renal transplantation (RT).<p></p> Methods: One hundred nineteen renal transplant recipients (first transplant, deceased donors) underwent cardiovascular MRI (CMR) as part of CV screening prior to inclusion on the waiting list. Data regarding transplant function and patient survival after transplantation were collected.<p></p> Results: Median post-transplant follow-up was 4.3 years (interquartile range (IQR) 1.9, 6.2). During the post-transplant period, 13 patients returned to dialysis after graft failure and 23 patients died with a functioning graft. Survival analyses, censoring for patients returning to dialysis, showed that pre-transplant LV hypertrophy and elevated LA volume were significantly associated with reduced survival after transplantation. Multivariate Cox regression analyses demonstrated that longer waiting time, poorer transplant function, presence of LV hypertrophy and higher LA volume on screening CMR and female sex were independent predictors of death in patients with a functioning transplant.<p></p> Conclusions: Presence of LVH and higher LA volume are significant, independent predictors of death in patients who are wait-listed and proceed with renal transplantation.<p></p> METHODS: One hundred nineteen renal transplant recipients (first transplant, deceased donors) underwent cardiovascular MRI (CMR) as part of CV screening prior to inclusion on the waiting list. Data regarding transplant function and patient survival after transplantation were collected.<p></p> RESULTS: Median post-transplant follow-up was 4.3 years (interquartile range (IQR) 1.9, 6.2). During the post-transplant period, 13 patients returned to dialysis after graft failure and 23 patients died with a functioning graft. Survival analyses, censoring for patients returning to dialysis, showed that pre-transplant LV hypertrophy and elevated LA volume were significantly associated with reduced survival after transplantation. Multivariate Cox regression analyses demonstrated that longer waiting time, poorer transplant function, presence of LV hypertrophy and higher LA volume on screening CMR and female sex were independent predictors of death in patients with a functioning transplant.<p></p> CONCLUSIONS: Presence of LVH and higher LA volume are significant, independent predictors of death in patients who are wait-listed and proceed with renal transplantation

The feasibility and acceptability of a psychosocial intervention to support people with dementia with Lewy bodies and family care partners

OBJECTIVES: Psychosocial support for people with dementia with Lewy bodies (DLB) and family care partners is frequently lacking, despite the need expressed by those with lived experience. Our objective was to examine the feasibility and acceptability of an intervention designed to build coping capability. DESIGN: The design was non-randomised with all participants receiving the intervention. SETTING: The setting was a Memory Assessment and Management Service in the Northeast of England. PARTICIPANTS: Participants comprised 19 dyads consisting of a person with DLB and a family care partner. INTERVENTION: The intervention was group-based, with weekly sessions attended for up to four successive weeks. It was informed by Social Cognitive Theory. MEASUREMENTS: Data were collected on recruitment, attendance and attrition, self-efficacy, mood, stress and participant experience. RESULTS: Recruitment was achieved with minimal attrition and three successive groups were delivered. Care partners felt more in control and able to cope in at least 3 of 13 areas with 73% feeling this way in eight or more areas. Three themes were identified from post-intervention interviews: people like us, outcomes from being a group member and intervention design. CONCLUSIONS: A DLB-specific group intervention is acceptable to people with DLB and family care partners, and recruitment is feasible within a specialist service. Participation may enhance understanding of this condition and reduce social isolation. It may improve care partners' coping capability particularly if targeted towards those with low prior understanding of DLB and more stress. Means of evaluating outcomes for people with DLB need further development

Spectacular Shells in the Host Galaxy of the QSO MC2 1635+119

We present deep HST/ACS images and Keck spectroscopy of MC2 1635+119, a QSO hosted by a galaxy previously classified as an undisturbed elliptical. Our new images reveal dramatic shell structure indicative of a merger event in the relatively recent past. The brightest shells in the central regions of the host are distributed alternately in radius, with at least two distinct shells on one side of the nucleus and three on the other, out to a distance of ~13 kpc. The light within the five shells comprises ~6% of the total galaxy light. Lower surface brightness ripples or tails and other debris extend out to a distance of ~65 kpc. A simple N-body model for a merger reproduces the inner shell structure and gives an estimate for the age of the merger between ~30 Myr and ~1.7 Gyr, depending on a range of reasonable assumptions. While the inner shell structure is suggestive of a minor merger, the total light contribution from the shells and extended structures are more indicative of a major merger. The spectrum of the host galaxy is dominated by a population of intermediate age (~1.4 Gyr), indicating a strong starburst episode that may have occurred at the time of the merger event. We speculate that the current QSO activity may have been triggered in the recent past by either a minor merger, or by debris from an older (~Gyr) major merger that is currently ``raining'' back into the central regions of the merger remnant.Comment: 14 pages, 5 figures. Accepted for publication in the Astrophysical Journa

Isolation and identification of actinomycetes from Fire Mountain, China, and the elicitation of antimicrobial production

PhD ThesisThe increasing emergence of antimicrobial resistance alongside the decrease of novel compounds being discovered is an emerging worldwide health threat. The discovery of novel antibiotics, especially from natural products, is an important area of research for all. Natural products from secondary metabolites produced by actinomycetes are a recognised and established source of antimicrobial compounds, with many clinically relevant drugs on the market. This thesis aimed to investigate several approaches to the discovery of novel antimicrobial compounds from putative streptomycetes, using classical methodology alongside elicitation techniques. In chapter 3, selective isolation and classical whole cell approaches were investigated to isolate putatively novel strains of Streptomyces spp. from a soil sample taken from Fire Mountain in China, which were subsequently tested for their ability to produce bioactive secondary metabolites. The results showed incidences of broad-spectrum activity from >7% of isolates tested. The known compounds streptothricin and wailupemyin were purified and identified from the Fire Mountain isolates, as well as a compound that inhibited the growth of multidrug resistant strains. In chapter 4, various chemical, biological, and co-culturing techniques were carried out to investigate how these methods could induce the production of antimicrobial compounds from non-active isolates. Ferrioxaime E, a siderophore commonly isolated from Streptomyces spp., was identified from DEM60169 and DEM60164. DEM60169 was also found to produce lipozalidinone A, a broad-spectrum antimicrobial compound, and gentamicins C1 and C1a. Additionally, the use of solid scaffolds was investigated to simulate the natural soil environment that the strains were isolated from. Co-culturing techniques were employed to stimulate the production of antimicrobial secondary metabolites. Six-hundred and twenty incidences of antimicrobial action were observed using this method, and twenty strain combinations transferred to liquid media to investigate further. It is concluded that elicitation techniques should be utilised to further investigate the production of antimicrobial compounds from Streptomyces spp

Smoking cessation for improving mental health (Protocol)

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To investigate the association between tobacco smoking cessation and subsequent mental health outcomes

Surfactant-free purification of membrane protein complexes from bacteria: application to the staphylococcal penicillin-binding protein complex PBP2/PBP2a

Surfactant-mediated removal of proteins from biomembranes invariably results in partial or complete loss of function and disassembly of multi-protein complexes. We determined the capacity of styrene-co-maleic acid (SMA) co-polymer to remove components of the cell division machinery from the membrane of drug-resistant staphylococcal cells. SMA-lipid nanoparticles solubilized FtsZ-PBP2-PBP2a complexes from intact cells, demonstrating the close physical proximity of these proteins within the lipid bilayer. Exposure of bacteria to (-)-epicatechin gallate, a polyphenolic agent that abolishes β-lactam resistance in staphylococci, disrupted the association between PBP2 and PBP2a. Thus, SMA purification provides a means to remove native integral membrane protein assemblages with minimal physical disruption and shows promise as a tool for the interrogation of molecular aspects of bacterial membrane protein structure and function

“Couch-to-5k or Couch to Ouch to Couch!?” Who Takes Part in Beginner Runner Programmes in the UK and Is Non-Completion Linked to Musculoskeletal Injury?

Physical activity has mental and physical health benefits, however globally, three-quarters of the population do not meet physical activity guidelines. The Couch-to-5k is a beginner runners pro-gramme aimed at increasing physical activity. However, this programme lacks an evidence-base and it is unclear who is attracted to the programme, plus running has a high rate of musculoskel-etal (MSK) injuries. The aims of this study were to identify the characteristics of people taking part, the incidence of MSK injuries and to explore the experiences of people who dropped out of a modified 9-week Couch-to-5k programme. 110 runners (average age was 47.1±13.7 years) partic-ipated in the study which involved completion of questionnaires (running experience and foot-wear information, quality of life (EQ-5D-5L), physical activity level (IPAQ-short form), MSK inju-ry history and knee condition (SNAPPS and KOOS-PS)) at the start, middle and end of the pro-gramme collecting socio-demographics (age, gender, social economic status, relationship status, education level), body mass index, running experience , footwear information, quality of life, physical activity levels, MSK injuries and knee condition. Fifteen drop-outs were interviewed to explore experiences of the programme. Runners were mainly females (81.8%) with an average age 47.1-year-olds, average body mass index of 28.1kg.m2, mainly from high socio-economic lev-els, married and educated to degree level. 64% of the sample had previous running experience and were classified as active. Half the sample self-reported pain / discomfort and 37.2% reported anxiety / depression at the start of the programme via the EQ-5D-5L scale. Self-reported health scores increased (p = 0.047) between baseline (73.1±18.8 out of 100) and at the midpoint (81.2±11.6) but were no significant differences between any other time points (end point 79.7±17.5, p>0.05). Twenty-one injuries were reported during the programme (19%). Previous in-jury increased the risk of new injury (OR 7.56 95% CI 2.06 to 27.75). Only 27.3% completed the programme. Three themes emerged from interviews; MSK injury, negative emotions linked to non-completion and design of the programme. The Couch-to-5k may not attract diverse inactive populations, future work with larger sample sizes is needed to substantiate this finding. Drop-ping out was linked to MSK injury and progressive design, future programmes should consider including injury prevention advice and more flexible designs