THE TRANSFORMATIVE POTENTIAL OF LIGAPLANTS IN REPLICATING NATURAL TOOTH CONNECTIONS

Over the past decade, dental implants have become the gold standard in tooth replacement, with osseointegrated implants reigning supreme. However, these implants present certain limitations, notably the absence of the periodontal ligament (PDL). In response to this challenge, innovative periodontal ligament implants, known as ligaplants, have emerged. By combining tissue engineering principles with cutting-edge implant materials, ligaplants offer a promising alternative to traditional implants, showcasing superior biological performance and potentially extending prosthetic life.Dental implantology has witnessed a transformative shift over the last ten years, with osseointegrated implants dominating the landscape of tooth replacement. Despite their widespread adoption, these implants face inherent drawbacks, chief among them being the lack of a periodontal ligament (PDL).The development of ligaplants, characterized by a meticulously designed periodontal ligament, represents a groundbreaking solution to address this limitation

Flooding attacks to internet threat monitors (ITM): Modeling and counter measures using botnet and honeypots

The Internet Threat Monitoring (ITM),is a globally scoped Internet monitoring system whose goal is to measure, detect, characterize, and track threats such as distribute denial of service(DDoS) attacks and worms. To block the monitoring system in the internet the attackers are targeted the ITM system. In this paper we address flooding attack against ITM system in which the attacker attempt to exhaust the network and ITM's resources, such as network bandwidth, computing power, or operating system data structures by sending the malicious traffic. We propose an information-theoretic frame work that models the flooding attacks using Botnet on ITM. Based on this model we generalize the flooding attacks and propose an effective attack detection using Honeypots

Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training: A randomized controlled pilot study

AbstractPurposeTo evaluate the efficacy and safety of the glycoside fraction of fenugreek (Trigonella foenum-graecum) seeds (Fenu-FG) on physiological parameters related to muscle anabolism, androgenic hormones, and body fat in healthy male subjects during an 8-week resistance training program using a prospective, randomized, double-blind, placebo controlled design.MethodsSixty healthy male subjects were randomized to ingest capsules of Fenu-FG (1 capsule of 300 mg, twice per day) or the matching placebo at a 1:1 ratio. The subjects participated in a supervised 4-day per week resistance-training program for 8 weeks. The outcome measurements were recorded at recruitment (baseline) and at the end of the treatment (8 weeks). The efficacy outcome included serum testosterone (total and free) levels, muscle strength and repetitions to failure, metabolic markers for anabolic activity (serum creatinine and blood urea nitrogen), and % body fat. The standard safety measurements such as adverse events monitoring, vital signs, hematology, biochemistry, and urinalysis were performed.ResultsFenu-FG supplementation demonstrated significant anabolic and androgenic activity as compared with the placebo. Fenu-FG treated subjects showed significant improvements in body fat without a reduction in muscle strength or repetitions to failure. The Fenu-FG supplementation was found to be safe and well-tolerated.ConclusionFenu-FG supplementation showed beneficial effects in male subjects during resistance training without any clinical side effects

Detection of Reliable Software Using SPRT on Interval Domain Data

In Classical Hypothesis testing volumes of data is to be collected and then the conclusions are drawn which may take more time. But, Sequential Analysis of statistical science could be adopted in order to decide upon the reliable / unreliable of the developed software very quickly. The procedure adopted for this is, Sequential Probability Ratio Test (SPRT). In the present paper we proposed the performance of SPRT on Interval domain data using Weibull model and analyzed the results by applying on 5 data sets. The parameters are estimated using Maximum Likelihood Estimatio

Modeling and Counter Measures of Flooding Attacks to Internet Threat Monitors (ITM): Using Botnet and Group-Testing approach

The Internet Threat Monitoring (ITM),is a globally scoped Internet monitoring system whose goal is to measure, detect, characterize, and track threats such as distribute denial of service(DDoS) attacks and worms. To block the monitoring system in the internet the attackers are targeted the ITM system. In this paper we address flooding attack against ITM system in which the attacker attempt to exhaust the network and ITM2019;s resources, such as network bandwidth, computing power, or operating system data structures by sending the malicious traffic. We propose an information-theoretic frame work that models the flooding attacks using Botnet on ITM.we propose a novel group testing (GT)-based approach deployed on back-end servers, which not only offers a theoretical method to obtain short detection delay and low false positive/negative rate, but also provides an underlying framework against general network attacks

Possibilities and Challenges of De-privatisation of Classrooms in a Developing Nation

De-privatisation of classrooms signifies the opening of classrooms so teachers can ‘observe’, ‘be observed’ or ‘engage in team teaching’. This study examined the perceptions and practices of school staff to determine the possibilities and challenges of de-privatisation of classrooms in Fiji. Employing case study methodology, data were gathered from two urban secondary schools using on-line questionnaires and face-to-face interviews. A total of 71 questionnaires and 16 interviews were analysed using quantitative and qualitative methods respectively. There were several findings which emerged from the study. Firstly, that there is a strong correlation between ‘observe’ and ‘be observed’ by colleagues. Secondly, that teachers’ major challenges in regard to de-privatisation of classrooms are the workload and school culture. Thirdly, in developing countries, colleagues and the heads of department are seen as the most suitable people in the school context to cultivate the effects of de-privatisation particularly inside the classroom where support is needed to help teachers improve the instructional practices. Overall, teachers, heads of department and the school administrators need to work together to establish a culture of professional learning communities (PLCs) to enhance teachers’ instructional practices

Preclinical safety evaluation of low molecular weight galactomannans based standardized fenugreek seeds extract

The objective of the present study was to evaluate acute oral toxicity, subchronic toxicity, and mutagenic potential of low molecular weight galactomannans based standardized fenugreek seeds extract (LMWGAL-TF) in laboratory animals rats as per Organization for Economic Co-operation and Development (OECD) guidelines. For the acute toxicity (AOT) study, LMWGAL-TF was orally administered to Sprague-Dawley (SD) rats at a dose of 2000 mg/kg with vehicle control (VC) group (n = 5 per sex per group) as per OECD guideline no. 423. For the repeated dose toxicity study, the SD rats were orally administered with a daily oral dose of LMWGAL-TF 250, 500 and 1000 mg/kg/day with VC group (n = 15 per sex) for a period of 90 days followed by a recovery period of 28 days as per OECD guideline no. 408. The effects on body weight, food and water consumption, organ weights with hematology, clinical biochemistry, and histology were studied. The mutagenic potential of LMWGAL-TF was tested using reverse mutation assay (AMES test, OECD guideline No. 471). The LMWGAL-TF did not show mortality or treatment-related adverse signs during acute (dose 2000 mg/kg) and subchronic (90-days repeated dose 250, 500 and 1000 mg/kg) administration. The LMWGAL-TF showed oral lethal dose (LD50) more than 2000 mg/kg during AOT study. The dose of 1000 mg/kg was found as no observed adverse effect level (NOAEL) in rats during subchronic toxicity study. Furthermore, LMWGAL-TF did not show mutagenic potential in vitro. In conclusion, LMWGAL-TF was found safe during acute and subchronic (90 days repeated dose) toxicity studies in rats with no mutagenicity

Herbal-based Traditional Medicinal Knowledge of Local Inhabitants in Rudraprayag District of Uttarakhand, India

Traditional medicinal knowledge has gained much attention recently due to rejuvenation of faith in traditional system of medicines. The Indian Himalaya is a source of plant based indigenous medicinal knowledge based on local plant diversity. Surveys were conducted in Rudraprayag district of Uttarakhand, India to collect indigenous information on primary health care. 29 formulations using 159 plant species were recorded treating 119 ailments in 13 broad therapeutic classes. Results have been compared with traditional knowledge from other parts of India