Comparing Results of Five Glomerular Filtration Rate-Estimating Equations in the Korean General Population. MDRD Study, Revised Lund-Malmö, and Three CKD-EPI Equations

Estimated glomerular filtration rate (eGFR) is a widely used index of kidney function. Recently, new formulas such as the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations or the Lund-Malmö equation were introduced for assessing eGFR. We compared them with the Modification of Diet in Renal Disease (MDRD) Study equation in the Korean adult population. METHODS: The study population comprised 1,482 individuals (median age 51 [42-59] yr, 48.9% males) who received annual physical check-ups during the year 2014. Serum creatinine (Cr) and cystatin C (CysC) were measured. We conducted a retrospective analysis using five GFR estimating equations (MDRD Study, revised Lund-Malmö, and Cr and/or CysC-based CKD-EPI equations). Reduced GFR was defined as eGFR <60 mL/min/1.73 m². RESULTS: For the GFR category distribution, large discrepancies were observed depending on the equation used; category G1 (≥90 mL/min/1.73 m²) ranged from 7.4-81.8%. Compared with the MDRD Study equation, the other four equations overestimated GFR, and CysC-based equations showed a greater difference (-31.3 for CKD-EPI(CysC) and -20.5 for CKD-EPI(Cr-CysC)). CysC-based equations decreased the prevalence of reduced GFR by one third (9.4% in the MDRD Study and 2.4% in CKD-EPI(CysC)). CONCLUSIONS: Our data shows that there are remarkable differences in eGFR assessment in the Korean population depending on the equation used, especially in normal or mildly decreased categories. Further prospective studies are necessary in various clinical settings

OGLE-2013-BLG-0578L: Microlensing Binary Composed of A Brown Dwarf And An M Dwarf

Determining physical parameters of binary microlenses is hampered by the lack of information about the angular Einstein radius due to the difficulty of resolving caustic crossings. In this paper, we present the analysis of the binary microlensing event OGLE-2013-BLG-0578, for which the caustic exit was precisely predicted in advance from real-time analysis, enabling to densely resolve the caustic crossing and to measure the Einstein radius. From the mass measurement of the lens system based on the Einstein radius combined with the additional information about the lens parallax, we identify that the lens is a binary that is composed of a late-type M-dwarf primary and a substellar brown-dwarf companion. The event demonstrates the capability of current real-time microlensing modeling and the usefulness of microlensing in detecting and characterizing faint or dark objects in the Galaxy.Comment: 5 pages, 2 tables, 4 figures, submitted to Ap

A way to measure the water quality of the LHAASO-WCDA with cosmic muon signals

The Large High Altitude Air Shower Observatory (LHAASO) is to be built at Daocheng, Sichuan Province, China. As one of the major components of the LHAASO project, a Water Cherenkov Detector Array (WCDA), with an area of 78,000~$\rm m^{2}$, contains 350,000~tons of purified water. The water transparency and its stability are critical for successful long-term operation of this project. To gain full knowledge of the water Cherenkov technique and investigate the engineering issues, a 9-cell detector array has been built at the Yangbajing site, Tibet, China. With the help of the distribution of single cosmic muon signals, the monitoring and measurement of water transparency are studied. The results show that a precision of several percent can be obtained for the attenuation length measurement, which satisfies the requirements of the experiment. In the near future, this method could be applied to the LHAASO-WCDA project

Implementation of secondary stroke prevention protocol for ischaemic stroke patients in primary care

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OGLE-2015-BLG-0051/KMT-2015-BLG-0048Lb: a Giant Planet Orbiting a Low-mass Bulge Star Discovered by High-cadence Microlensing Surveys

We report the discovery of an extrasolar planet detected from the combined data of a microlensing event OGLE-2015-BLG-0051/KMT-2015-BLG-0048 acquired by two microlensing surveys. Despite that the short planetary signal occurred in the very early Bulge season during which the lensing event could be seen for just about an hour, the signal was continuously and densely covered. From the Bayesian analysis using models of the mass function, matter and velocity distributions combined with the information of the angular Einstein radius, it is found that the host of the planet is located in the Galactic bulge. The planet has a mass $0.72_{-0.07}^{+0.65}\ M_{\rm J}$ and it is orbiting a low-mass M-dwarf host with a projected separation $d_\perp=0.73 \pm 0.08$ AU. The discovery of the planet demonstrates the capability of the current high-cadence microlensing lensing surveys in detecting and characterizing planets.Comment: 7 pages, 6 figure

OGLE-2016-BLG-0613LABb: A Microlensing Planet in a Binary System

We present the analysis of OGLE-2016-BLG-0613, for which the lensing light curve appears to be that of a typical binary-lens event with two caustic spikes but with a discontinuous feature on the trough between the spikes. We find that the discontinuous feature was produced by a planetary companion to the binary lens. We find 4 degenerate triple-lens solution classes, each composed of a pair of solutions according to the well-known wide/close planetary degeneracy. One of these solution classes is excluded due to its relatively poor fit. For the remaining three pairs of solutions, the most-likely primary mass is about $M_1\sim 0.7\,M_\odot$ while the planet is a super-Jupiter. In all cases the system lies in the Galactic disk, about half-way toward the Galactic bulge. However, in one of these three solution classes, the secondary of the binary system is a low-mass brown dwarf, with relative mass ratios (1 : 0.03 : 0.003), while in the two others the masses of the binary components are comparable. These two possibilities can be distinguished in about 2024 when the measured lens-source relative proper motion will permit separate resolution of the lens and source.Comment: 14 pages, 9 figure

Prediction of Advanced Fibrosis in Nonalcoholic Fatty Liver Disease: An Enhanced Model of BARD Score.

UNLABELLED: BACKGROUNDAIMS: The BARD score is a model to detect advanced liver fibrosis in nonalcoholic fatty liver disease (NAFLD) patients. The aims of this study were to identify additional factors and then to build an enhanced version of the BARD score. METHODS: One hundred seven patients with biopsy-proven NAFLD were enrolled retrospectively. Logistic regressions were performed to identify independent risk factors for advanced liver fibrosis (stage 3 or 4). An enhanced model of the BARD score (BARDI score) was built and evaluated with a receiver operating characteristic (ROC) curve. RESULTS: In multivariate analysis, age (odds ratio [OR], 0.89; p=0.04), aspartate aminotransferase/alanine aminotransferase ratio (OR, 1.73; p CONCLUSIONS: The BARDI score had an improved PPV over the BARD score and maintained an excellent NPV. Further study is warranted for its external validation and comparison with other models

Travel Characteristics and Yellow Fever Vaccine Usage Among US Global TravEpiNet Travelers Visiting Countries with Risk of Yellow Fever Virus Transmission, 2009–2011

Yellow fever (YF) vaccine-associated serious adverse events and changing YF epidemiology have challenged healthcare providers to vaccinate only travelers whose risk of YF during travel is greater than their risk of adverse events. We describe the travel characteristics and YF vaccine use among US travelers visiting Global TravEpiNet clinics from January of 2009 to March of 2011. Of 16,660 travelers, 5,588 (34%) had itineraries to areas with risk of YF virus transmission. Of those travelers visiting one country with YF risk (N = 4,517), 71% were vaccinated at the visit, and 20% were presumed to be immune from prior vaccination. However, travelers visiting friends and relatives (odds ratio [OR] = 2.57, 95% confidence interval [95% CI] = 1.27–5.22) or going to Nigeria (OR = 3.01, 95% CI = 1.37–6.62) were significantly more likely to decline vaccination. To optimize YF vaccine use, clinicians should discuss an individual's risk–benefit assessment of vaccination and close knowledge gaps regarding vaccine use among at-risk populations

The First Neptune Analog or Super-Earth with Neptune-like Orbit: MOA-2013-BLG-605Lb

We present the discovery of the first Neptune analog exoplanet or super-Earth with Neptune-like orbit, MOA-2013-BLG-605Lb. This planet has a mass similar to that of Neptune or a super-Earth and it orbits at $9\sim 14$ times the expected position of the snow-line, $a_{\rm snow}$, which is similar to Neptune's separation of $11\,a_{\rm snow}$ from the Sun. The planet/host-star mass ratio is $q=(3.6\pm0.7)\times 10^{-4}$ and the projected separation normalized by the Einstein radius is $s=2.39\pm0.05$. There are three degenerate physical solutions and two of these are due to a new type of degeneracy in the microlensing parallax parameters, which we designate "the wide degeneracy". The three models have (i) a Neptune-mass planet with a mass of $M_{\rm p}=21_{-7}^{+6} M_{Earth}$ orbiting a low-mass M-dwarf with a mass of $M_{\rm h}=0.19_{-0.06}^{+0.05} M_\odot$, (ii) a mini-Neptune with $M_{\rm p}= 7.9_{-1.2}^{+1.8} M_{Earth}$ orbiting a brown dwarf host with $M_{\rm h}=0.068_{-0.011}^{+0.019} M_\odot$ and (iii) a super-Earth with $M_{\rm p}= 3.2_{-0.3}^{+0.5} M_{Earth}$ orbiting a low-mass brown dwarf host with $M_{\rm h}=0.025_{-0.004}^{+0.005} M_\odot$ which is slightly favored. The 3-D planet-host separations are 4.6$_{-1.2}^{+4.7}$ AU, 2.1$_{-0.2}^{+1.0}$ AU and 0.94$_{-0.02}^{+0.67}$ AU, which are $8.9_{-1.4}^{+10.5}$, $12_{-1}^{+7}$ or $14_{-1}^{+11}$ times larger than $a_{\rm snow}$ for these models, respectively. The Keck AO observation confirm that the lens is faint. This discovery suggests that low-mass planets with Neptune-like orbit are common. So processes similar to the one that formed Neptune in our own Solar System or cold super-Earth may be common in other solar systems.Comment: 54 pages, 10 figures, 13 tables, Accepted for publication in the Ap

Space-based Microlens Parallax Observation As a Way to Resolve the Severe Degeneracy between Microlens-parallax and Lens-orbital Effect

In this paper, we demonstrate the severity of the degeneracy between the microlens-parallax and lens-orbital effects by presenting the analysis of the gravitational binary-lens event OGLE-2015-BLG-0768. Despite the obvious deviation from the model based on the the linear observer motion and the static binary, it is found that the residual can be almost equally well explained by either the parallactic motion of the Earth or the rotation of the binary lens axis, resulting in the severe degeneracy between the two effects. We show that the degeneracy can be readily resolved with the additional data provided by space-based microlens parallax observations. Enabling to distinguish between the two higher-order effects, space-based microlens parallax observations will make it possible not only to accurately determine the physical lens parameters but also to further constrain the orbital parameters of binary lenses.Comment: 6 pages, 5 figure