Personalidade, epilepsia, homicídio

The authors describe the case of a woman with epilepsy who murdered her husband and discusses the connections between the facts.Os autores descrevem o caso de uma mulher com antecedente de epilepsia que assassinou seu marido tentando estabelecer um nexo causal entre os fatos

Comparison between Air Temperature and Land Surface Temperature for the City of São Paulo, Brazil

This study aims to identify the relationship between changes in temperature regarding urbanization processes and seasonality in the city of São Paulo, located in the Tropic of Capricorn. The land surface temperature (LST) results were compared to official weather stations measurements, identifying in the spring–summer period 65.5% to 86.2% accuracy, while in the autumn–winter period, the results ranged from 58.6% to 93.1% accuracy, when considering the standard deviation and the temperature probe error. The mean MAE and mean RMSE range from 1.2 to 1.9 °C, with 83.0% of the values being ≤2.7 °C, and the coefficient of determination values are R = 0.81 in spring–summer and R = 0.82 in autumn–winter. Great thermal amplitude was estimated in the spring–summer season, with a difference in LST of the built-up space and rural area ranging from 5.8 and 11.5 °C, while in the autumn–winter season, the LST is more distributed through the city, with differences ranging from 4.4 to 8.5 °C. In addition, the current study suggests remote sensing as a reliable, cheap, and practical methodology to assist climate in order to support public policies and decision-making actions regarding environmental and urban planning.publishedVersio

Mortalidade prematura por câncer de colo uterino: estudo de séries temporais interrompidas

OBJETIVO: Verificar o efeito do Pacto Pela Saúde na mortalidade prematura (30–69 anos) atribuída a câncer de colo uterino no Brasil e nas suas macrorregiões, utilizando modelagem de séries temporais interrompidas. MÉTODOS: A regressão segmentada foi usada para avaliar “mudança de nível” e “mudança de tendência” das taxas de mortes prematuras por câncer de colo uterino no período pós-Pacto (2010–2018), controlando pelo período pré-Pacto (1998–2006). Entendendo o triênio 2007–2009 como essencial para adesão e implantação da política ele foi excluído da modelagem principal, mas avaliado na análise de sensibilidade. RESULTADOS: De 1998 a 2018, houve mais de 119 mil óbitos por câncer de colo uterino, em mulheres de 30 a 69 anos, no Brasil. A região Norte experimentou as taxas mais altas (> 20 por 100 mil). Comparando à linha de base (1998–2006), a regressão segmentada mostrou progressiva elevação das mortes por câncer de colo uterino no Brasil como um todo (coeficiente angular = 0,513; IC95% 0,430 a 0,596) e nas regiões Sudeste (coeficiente = 0,515; IC95% 0,358 a 0,674), Sul (coeficiente = 0,925; IC95% 0,642 a 1,208), e Centro-Oeste (coeficiente = 0,590; IC95% 0,103 a 1,077). A região Nordeste apresentou os efeitos mais promissores com redução imediata no nível (-0,635; IC95% -1,177 a -0,092) e redução progressiva na tendência de mortes prematuras (coeficiente= -0,151; IC95% -0,231 a -0,007). CONCLUSÕES: As taxas de mortalidade prematuras por câncer de colo uterino são altas no Brasil e nas suas macrorregiões. Esta série temporal interrompida não foi capaz de revelar efetividade das iniciativas relacionadas ao Pacto pela Saúde sobre as mortes prematuras por câncer de colo uterino nacionalmente e tampouco em todas as macrorregiões igualmente. Os melhores resultados estão restritos à região Nordeste.OBJECTIVE: To verify the effect of the Pact for Health on premature mortality (30–69 years) attributed to cervical cancer in Brazil and its macroregions, using interrupted time series analysis. METHODS: Segmented regression was used to assess “change in level” and “change in trend” in premature mortality rates attributed to cervical cancer considering the post-Pact period (2010-2018), controlling by the pre-Pact period (1998–2006). Understanding the triennium 2007-2009 as essential for the adoption and implementation of the policy, it was excluded from the main modeling, but assessed in the sensitivity analysis. RESULTS: From 1998 to 2018, there were more than 119,000 deaths due to cervical cancer in women aged 30 to 69 years in Brazil. The Northern region experienced the highest rates (> 20 per 100,000). Comparing with baseline (1998–2006), segmented regression showed a progressive increase in changing trend from cervical cancer deaths in Brazil as a whole (coefficient = 0.513; 95%CI 0.430 to 0.596) and in the Southeast region (coefficient = 0.515; 95%CI 0.358 to 0.674), South region (coefficient = 0.925; 95%CI 0.642 to 1.208), and Midwest region (coefficient = 0.590; 95%CI 0.103 to 1.077). The Northeast region presented the most promising effects with immediate reduction in change level (-0.635; 95%CI -1.177 to -0.092) and progressive reduction in the changing trend of premature deaths (coefficient= -0.151; 95%CI -0.231 to -0.007). CONCLUSIONS: Premature mortality rates due to cervical cancer are high in Brazil and its macroregions. This interrupted time series was not able to reveal the effectiveness of initiatives related to the Pact for Health on premature deaths from cervical cancer nationally and in all macroregions equally. The best results are restricted to the Northeast region

Fixação biológica do nitrogênio em soja sob restrição hídrica e exposta ao 1‑metilciclopropeno

The objective of this work was to assess the effects of 1‑methylcyclopropene (1‑MCP) on traits related with biological nitrogen fixation on 'BRS 268' soybean (Glycine max) subjected to water restriction. Plants were either exposed to drought between 32 (R2) and 47 (R3) days after sowing (DAS) or kept well‑watered, in combination with exposure or not to 1‑MCP. On the second day under drought (34 DAS), plants from both water conditions were exposed to 1‑MCP in a hermetically sealed chamber for 15 hours. Control plants, dry or well‑watered, that were not exposed to 1‑MCP were kept in a separate chamber. At 36 (R2) and 47 (R3) DAS, shoot and root dry weights, leaf area index, number and dry weight of nodules, total ureides in sap, and N concentration in leaves were assessed. From 47 DAS on, extra plants were well watered until physiological maturity (R8) and assessed for yield components. Water restriction increased ureides in sap and reduced N in leaves in R2; reduced the number and mass of nodules, shoot dry weight, and leaf area index in R3; and reduced the number of pods and seed mass of plants not exposed to 1‑MCP. However, when plants are exposed to 1‑MCP, there is an attenuation of water restriction effects.O objetivo deste trabalho foi avaliar os efeitos do 1‑metilciclopropeno (1‑MCP) em parâmetros relacionados à fixação biológica de nitrogênio em soja (Glycine max) 'BRS 268' submetida à restrição hídrica. As plantas foram submetidas à seca entre 32 (R2) e 47 (R3) dias após a semeadura (DAS) ou mantidas bem irrigadas, em combinação com exposição ou não ao 1‑MCP. No segundo dia sob seca (34 DAS), as plantas de ambas as condições hídricas foram expostas ao 1‑MCP em câmara hermeticamente fechada por 15 horas. As plantas‑controle, sob restrição hídrica ou bem irrigadas, não expostas ao 1‑MCP foram mantidas em câmara separada. Aos 36 (R2) e 47 (R3) DAS, foram avaliados massa seca da parte aérea e das raízes, índice de área foliar, número e massa seca de nódulos, ureídos totais na seiva e concentração de N foliar. A partir dos 47 DAS, as plantas remanescentes foram mantidas bem irrigadas até a maturação fisiológica (R8) e os componentes de produção foram avaliados. A restrição hídrica aumentou os ureídos na seiva e reduziu o N foliar em R2; reduziu o número e a massa de nódulos, a massa seca da parte aérea e o índice de área foliar em R3; e reduziu o número de vagens e a massa de sementes em plantas sem exposição ao 1‑MCP. No entanto, quando as plantas são expostas ao 1‑MCP, há atenuação do efeito da restrição hídrica

Clinical and dermal thickness assessment one year after hyaluronic acid filler treatment

INTRODUÇÃO: Poucos estudos avaliam a durabilidade dos produtos de preenchimento facial de forma objetiva e não-invasiva. O objetivo deste estudo foi avaliar a durabilidade de formulação de ácido hialurônico (Derma Hyal ®) no preenchimento de sulco nasogeniano, comparando percepção do efeito clínico e espessura de partes moles medida por ultrassonografia. MÉTODO: Dez mulheres foram tratadas. Avaliação foi realizada após um, três, seis, nove e doze meses, clinicamente e por ultrassonografia. RESULTADOS: A média da espessura à ultrassonografia foi 0,38 ± 0,14 no pré, 0,69 ± 0,19 após 1 mês, 0,65 ± 0,17 após 3 meses, 0,61 ± 0,22 após 6 meses, 0,57 ± 0,23 após 9 meses e 0,55 ± 0,14 após 12 meses. Os dados analisados pelo teste Friedman não se mostraram estatisticamente significativos. Em relação à satisfação, aos 6 meses, 3 pacientes consideraram o resultado insatisfatório, 5, pouco satisfatório e 2, satisfatório. Apenas uma paciente considerou o resultado satisfatório aos 9 meses. Aos 12 meses, uma considerou pouco satisfatório e as demais, insatisfatório. Todas responderam que realizariam novamente o procedimento. CONCLUSÕES: A ultrassonografia demonstrou ser método objetivo e não-invasivo na avaliação da durabilidade de preenchimento, desde que avaliado com correlação clínica. Demonstrou-se aumento da espessura cutânea até 12 meses após injeção em sulco nasogeniano (SNG), com decréscimo progressivo. Embora exista diferença dos valores da ultrassonografia ao longo do tempo, essas não foram estatisticamente significantes. Clinicamente, o efeito percebido pelas pacientes se deu até o nono mês após aplicação do produto avaliado.BACKGROUND: Few scientific studies evaluate the durability of existent fillers with objective parameters and non invasive methods. The objective of this study was to evaluate durability of a hyaluronic acid formula (Derma Hyal ®) in the nasolabial fold treatment, comparing the perception of clinical effect and soft tissue thickness measured by ultrasound. METHODS: Ten women were treated. Evaluation was made before, after 1, 3, 6, 9 and 12 months, clinically and by ultrasound. RESULTS: Median ultrasound thickness was 0.38 ± 0.14 pre, 0.69 ± 0.19 after 1 month, 0.65 ± 0.17 after 3 months, 0.61 ± 0.22 after 6 months, 0, 57 ± 0.23 after 9 months and 0.55 ± 0.14 after 12 months. Data analyzed by Friedman's test were not statistically significant. Regarding patient satisfaction after 6 months, 3 considered the results unsatisfactory, 5 fairly satisfactory and 2 satisfactory. Only one patient considered the treatment satisfactory at 9 months. By 12 months one considered it fairly satisfactory and nine unsatisfactory. All patients said they would do treatment again in another opportunity. CONCLUSIONS: Ultrasound evaluation of dermal thickness after filler treatment proved to be an objective and non invasive method, since when associated with clinical examination. Increase in soft tissue thickness was demonstrated until 12 months after nasolabial fold injection, with progressive decrease after this period. Despite the increase in soft tissue thickness at ultrasound, it was not statistically significant. Clinical effect was noticed by patients until nine months after treatment with this product

Use of the checkerboard DNA-DNA hybridization technique for bacteria detection in Aedes aegypti (Diptera:Culicidae) (L.)

<p>Abstract</p> <p>Background</p> <p>Bacteria associated with insects can have a substantial impact on the biology and life cycle of their host. The checkerboard DNA-DNA hybridization technique is a semi-quantitative technique that has been previously employed in odontology to detect and quantify a variety of bacterial species in dental samples. Here we tested the applicability of the checkerboard DNA-DNA hybridization technique to detect the presence of <it>Aedes aegypti</it>-associated bacterial species in larvae, pupae and adults of <it>A. aegypti</it>.</p> <p>Findings</p> <p>Using the checkerboard DNA-DNA hybridization technique we could detect and estimate the number of four bacterial species in total DNA samples extracted from <it>A. aegypti </it>single whole individuals and midguts. <it>A. aegypti </it>associated bacterial species were also detected in the midgut of four other insect species, <it>Lutzomyia longipalpis, Drosophila melanogaster</it>, <it>Bradysia hygida </it>and <it>Apis mellifera</it>.</p> <p>Conclusions</p> <p>Our results demonstrate that the checkerboard DNA-DNA hybridization technique can be employed to study the microbiota composition of mosquitoes. The method has the sensitivity to detect bacteria in single individuals, as well as in a single organ, and therefore can be employed to evaluate the differences in bacterial counts amongst individuals in a given mosquito population. We suggest that the checkerboard DNA-DNA hybridization technique is a straightforward technique that can be widely used for the characterization of the microbiota in mosquito populations.</p

Remoção de estruturas vegetativas nos estádios iniciais sobre características produtivas e morfofisiológicas da soja

O objetivo deste estudo foi avaliar o desempenho produtivo e as características da soja após a remoção de estruturas vegetativas no desenvolvimento inicial. O trabalho foi conduzido na Fazenda Escola da UEL, nas safras 2012/13 e 2013/14, utilizando a cultivar BRS 360 RR, num delineamento em blocos casualizados com quatro tratamentos e cinco repetições. Os tratamentos foram: 1- Testemunha; 2- Remoção dos cotilédones em VC; 3- Corte do caule acima do nó cotiledonar em V1; 4- Corte do caule acima do nó das folhas primárias em V2. Avaliaram-se, em ambas as safras, a produtividade de grãos (kg ha-1) e, somente na primeira safra, os componentes do rendimento e características morfológicas como número de ramos, número de nós da haste principal, altura e diâmetro do colo. Os dados foram submetidos à análise de variância (p < 0,05) e as médias comparadas pelo teste de Tukey à 5%. Em ambas as safras, observou-se redução da produtividade apenas nos tratamentos 3 e 4 em relação à testemunha. O número de legumes por planta foi o único componente do rendimento com diferenças significativas, diminuindo nos tratamentos 3 e 4. Ainda, houve maior ramificação e número de nós nos tratamentos 1 e 2, enquanto estes tratamentos proporcionaram maiores alturas e menores diâmetros do colo. Conclui-se que o corte do caule acima do nó cotiledonar e acima do nó das folhas primárias prejudica a produtividade e as características morfofisiológicas da soja

Analgesia Evaluation of 2 NSAID Drugs as Adjuvant in Management of Chronic Temporomandibular Disorders

The aim of this triple-blind full-randomized clinical trial was to quantify analgesia in masticatory muscles and temporomandibular joints after occlusal splint therapy associated with the adjuvant administration of nonsteroidal anti-inflammatory drugs (NSAID) isolated or associated with other therapeutic agents. Pain relief was also recorded. Eighteen volunteers who had been suffering from chronic pain in masticatory muscles due to temporomandibular disorders were selected after anamnesis and assessment using RDC/TMD translated to Portuguese. The 3 proposed treatments were NSAID (sodium diclofenac), panacea (sodium diclofenac + carisoprodol + acetaminophen + caffeine), and a placebo. The total treatment duration was 10 days, preceded and succeeded by patients’ pain assessment. A washout interval of 11 days was established between each therapy. All participants received all treatments in different moments, in a full randomized crossover methodology. The assessment of drug therapies was performed using visual analogue scale for pain on palpation followed by 11-point numerical scale to quantify pain during treatment. Statistical analysis has shown that, after 10 days of treatment, all therapies were effective for pain relief. NSAID therapy promoted analgesia on the third day, while placebo only promoted analgesia in the eighth day. It has been concluded that sodium diclofenac used as splint adjuvant therapy, promotes significant analgesia in a shorter time

Clinical Study Analgesia Evaluation of 2 NSAID Drugs as Adjuvant in Management of Chronic Temporomandibular Disorders

The aim of this triple-blind full-randomized clinical trial was to quantify analgesia in masticatory muscles and temporomandibular joints after occlusal splint therapy associated with the adjuvant administration of nonsteroidal anti-inflammatory drugs (NSAID) isolated or associated with other therapeutic agents. Pain relief was also recorded. Eighteen volunteers who had been suffering from chronic pain in masticatory muscles due to temporomandibular disorders were selected after anamnesis and assessment using RDC/TMD translated to Portuguese. The 3 proposed treatments were NSAID (sodium diclofenac), panacea (sodium diclofenac + carisoprodol + acetaminophen + caffeine), and a placebo. The total treatment duration was 10 days, preceded and succeeded by patients&apos; pain assessment. A washout interval of 11 days was established between each therapy. All participants received all treatments in different moments, in a full randomized crossover methodology. The assessment of drug therapies was performed using visual analogue scale for pain on palpation followed by 11-point numerical scale to quantify pain during treatment. Statistical analysis has shown that, after 10 days of treatment, all therapies were effective for pain relief. NSAID therapy promoted analgesia on the third day, while placebo only promoted analgesia in the eighth day. It has been concluded that sodium diclofenac used as splint adjuvant therapy, promotes significant analgesia in a shorter time