Effect of Lupinus albus as protein supplement on yield, constituents, clotting properties and fatty acid composition in ewes' milk

The effect of feeding lupin seeds (Lupinus albus L.) as an alternative protein source in ewe diets was investigated. Two groups of 18 Sarda ewes were fed two different isonitrogenous diets: with lupin (L) seed, given after 12 h soaking, or soybean meal (SBM) as the main protein source. DMI, variations of body weight and milk production were unaffected by the treatment. Although not statistically significant, in the group fed L diet the production of milk fat and protein was higher. Clotting properties of milk were similar for the two treatments, probably due to the small differences in the milk protein contents. The fatty acid profile of milk was affected by treatment with a larger content of short (14.19 wt% versus 12.26 wt%)- and medium (49.37 wt% versus 47.76 wt%)-chain fatty acids in milk from ewes fed the L diet. CLA content was unaffected by treatment. Triglyceride content of fat from the two diets reflects the milk fatty acid composition. Indeed, milk from L diet showed a higher level of medium-chain triglycerides, which are of particular interest to consumers with concerns over health and heart disease. The inclusion of lupin seed in the diet of lactation ewes can be a means of achieving a more desirable triglyceride profile in milk fat. Milk with enhanced nutritive quality may promote wider market penetration of sheep dairy products

Fundamental Limits of Low-Density Spreading NOMA with Fading

Spectral efficiency of low-density spreading non-orthogonal multiple access channels in the presence of fading is derived for linear detection with independent decoding as well as optimum decoding. The large system limit, where both the number of users and number of signal dimensions grow with fixed ratio, called load, is considered. In the case of optimum decoding, it is found that low-density spreading underperforms dense spreading for all loads. Conversely, linear detection is characterized by different behaviors in the underloaded vs. overloaded regimes. In particular, it is shown that spectral efficiency changes smoothly as load increases. However, in the overloaded regime, the spectral efficiency of low- density spreading is higher than that of dense spreading

Pharmacokinetics and antinociceptive effects of tramadol and its metabolite O-desmethyltramadol following intravenous administration in sheep

Although sheep are widely used as an experimental model for various surgical procedures there is a paucity of data on the pharmacokinetics and efficacy of analgesic drugs in this species. The aims of this study were to investigate the pharmacokinetics of intravenously (IV) administered tramadol and its active metabolite O-desmethyltramadol (M1) and to assess the mechanical antinociceptive effects in sheep. In a prospective, randomized, blinded study, six healthy adult sheep were given 4 and 6\u2009mg/kg tramadol and saline IV in a cross-over design with a 2-week wash-out period. At predetermined time points blood samples were collected and physiological parameters and mechanical nociceptive threshold (MNT) values were recorded. The analytical determination of tramadol and M1 was performed using high performance liquid chromatography. Pharmacokinetic parameters fitted a two- and a non-compartmental model for tramadol and M1, respectively. Normally distributed data were analysed by a repeated mixed linear model. Plasma concentration vs. time profiles of tramadol and M1 were similar after the two doses. Tramadol and M1 plasma levels decreased rapidly in the systemic circulation, with both undetectable after 6\u2009h following drug administration. Physiological parameters did not differ between groups; MNT values were not statistically significant between groups at any time point. It was concluded that although tramadol and M1 concentrations in plasma were above the human minimum analgesic concentration after both treatments, no mechanical antinociceptive effects of tramadol were reported. Further studies are warranted to assess the analgesic efficacy of tramadol in sheep

What is the Benefit of Code-domain NOMA in Massive MIMO?

In overloaded Massive MIMO systems, wherein the number K of user equipments (UEs) exceeds the number of base station antennas M, it has recently been shown that non-orthogonal multiple access (NOMA) can increase performance. This paper aims at identifying cases of the classical operating regime K < M, where code-domain NOMA can also improve the spectral efficiency of Massive MIMO. Particular attention is given to use cases in which poor favorable propagation conditions are experienced. Numerical results show that Massive MIMO with planar antenna arrays can benefit from NOMA in practical scenarios where the UEs are spatially close to each other.Comment: To appear at the 2019 IEEE International Symposium on Personal, Indoor and Mobile Radio Communications (IEEE PIMRC 2019), 5 pages, 5 figure

Influence of microstructure and porosity on the fracture toughness of Al-Si-Mg alloy

With improving molten metal quality and foundry technology, cast alloys are expected to be used more commonly in critical applications. The demands for improved damage tolerance of cast aluminum alloys have increased the importance of fracture-related properties. In this perspective, the present study aims to evaluate the effect of four different aging treatments on fracture toughness of a die cast A356 Al alloy with and without Cu addition. Crack growth resistance curves (J-R curves) were experimentally evaluated using the ASTM E1820-17 standard procedure on 25 mm thick compact tension C(T) specimens. The influence of microstructure and porosity in hardness and fracture toughness (JIc) is discussed. In addition, microstructural observations were carried out to endorse the fracture mechanisms. Keywords: A356 aluminum alloy, Fracture toughness, J-R curves, Porosity, Microstructure, Hardness

Flexible Work Arrangements and Employee Work Attitudes: A Case-Based Inquiry of a Small Non-Profit Response to Crisis

We conducted an exploratory case-based study to examine the impact of adopting flexible work arrangements strategies in response to the Covid-19 pandemic on employee work attitudes for a small, regional non-profit. Our findings indicated the importance of managerial support and organizational commitment to moderate the relationship between flexible work arrangements and job satisfaction. We also explored the influence of technology efficacy and work-life balance on the model. Our paper provides support for the prior empirical and theoretical assumptions that flexible work arrangements can have a positive impact on employee work attitudes and may be an effective managerial tool in response to a crisis

Transcription factor KLF7 regulates differentiation of neuroectodermal and mesodermal cell lineages

Previous gene targeting studies in mice have implicated the nuclear protein Krüppel-like factor 7 (KLF7) in nervous system development while cell culture assays have documented its involvement in cell cycle regulation. By employing short hairpin RNA (shRNA)-mediated gene silencing, here we demonstrate that murine Klf7 gene expression is required for in vitro differentiation of neuroectodermal and mesodermal cells. Specifically, we show a correlation of Klf7 silencing with down-regulation of the neuronal marker microtubule-associated protein 2 (Map2) and the nerve growth factor (NGF) tyrosine kinase receptor A (TrkA) using the PC12 neuronal cell line. Similarly, KLF7 inactivation in Klf7-null mice decreases the expression of the neurogenic marker brain lipid-binding protein/fatty acid-binding protein 7 (BLBP/FABP7) in neural stem cells (NSCs). We also report that Klf7 silencing is detrimental to neuronal and cardiomyocytic differentiation of embryonic stem cells (ESCs), in addition to altering the adipogenic and osteogenic potential of mouse embryonic fibroblasts (MEFs). Finally, our results suggest that genes that are key for self-renewal of undifferentiated ESCs repress Klf7 expression in ESCs. Together with previous findings, these results provide evidence that KLF7 has a broad spectrum of regulatory functions, which reflect the discrete cellular and molecular contexts in which this transcription factor operates. © 2010 Elsevier Inc