Fine Selmer Groups and Isogeny Invariance

We investigate fine Selmer groups for elliptic curves and for Galois representations over a number field. More specifically, we discuss Conjecture A, which states that the fine Selmer group of an elliptic curve over the cyclotomic extension is a finitely generated $\mathbb{Z}_p$-module. The relationship between this conjecture and Iwasawa's classical $\mu=0$ conjecture is clarified. We also present some partial results towards the question whether Conjecture A is invariant under isogenies.Comment: 20 page

Maintaining soluble protein homeostasis between nuclear and cytoplasmic compartments across mitosis

The nuclear envelope (NE) is central to the architecture of eukaryotic cells, both as a physical barrier separating the nucleus from the cytoplasm and as gate-keeper of selective transport between them. However, in open mitosis, the NE fragments to allow for spindle formation and segregation of chromosomes, resulting in intermixing of nuclear and cytoplasmic soluble fractions. Recent studies have shed new light on the mechanisms driving reinstatement of soluble proteome homeostasis following NE reformation in daughter cells. Here, we pro-vide an overview of how mitotic cells confront this challenge to ensure continuity of basic cellular functions across generations and elaborate on the implications for the proteasome - a macromolecular machine that functions in both cytoplas-mic and nuclear compartments.Chemical Immunolog

Publizieren in der Soziologie im Jahr 2030

Taubert NC. Publizieren in der Soziologie im Jahr 2030. In: Weingart P, Taubert N, Berlin-Brandenburgische Akademie der Wissenschaften, eds. Wissenschaftliches Publizieren - Zwischen Digitalisierung, Leistungsmessung, Ökonomisierung und medialer Beobachtung. Forschungsberichte / Berlin-Brandenburgische Akademie der Wissenschaften, Interdisziplinäre Arbeitsgruppen. Vol Band 38. Berlin: De Gruyter Akademie Forschung; 2016: 295

Open Access und digitale Publikation aus der Perspektive von Wissenschaftsverlagen

Taubert NC. Open Access und digitale Publikation aus der Perspektive von Wissenschaftsverlagen. In: Weingart P, Taubert N, Berlin-Brandenburgische Akademie der Wissenschaften, eds. Wissenschaftliches Publizieren - Zwischen Digitalisierung, Leistungsmessung, Ökonomisierung und medialer Beobachtung. Berlin: De Gruyter Akademie Forschung; 2016: 75-102

Quantum critical point and scaling in a layered array of ultrasmall Josephson junctions

We have studied a quantum Hamiltonian that models an array of ultrasmall Josephson junctions with short range Josephson couplings, $E_J$, and charging energies, $E_C$, due to the small capacitance of the junctions. We derive a new effective quantum spherical model for the array Hamiltonian. As an application we start by approximating the capacitance matrix by its self-capacitive limit and in the presence of an external uniform background of charges, $q_x$. In this limit we obtain the zero-temperature superconductor-insulator phase diagram, $E_J^{\rm crit}(E_C,q_x)$, that improves upon previous theoretical results that used a mean field theory approximation. Next we obtain a closed-form expression for the conductivity of a square array, and derive a universal scaling relation valid about the zero--temperature quantum critical point. In the latter regime the energy scale is determined by temperature and we establish universal scaling forms for the frequency dependence of the conductivity.Comment: 18 pages, four Postscript figures, REVTEX style, Physical Review B 1999. We have added one important reference to this version of the pape

Limitations of Prostate Biopsy in Detection of Cribriform and Intraductal Prostate Cancer

Funding Information: Acknowledgments: Rui M. Bernardino is supported by Fundacao para a Ciencia e a Tecnologia (2022.13386.BD). Publisher Copyright: © 2023 European Association of UrologyBackground: The presence of cribriform morphology and intraductal carcinoma (IDC) in prostate biopsies and radical prostatectomy specimens is an adverse prognostic feature that can be used to guide treatment decisions. Objective: To assess how accurately biopsies can detect cribriform morphology and IDC cancer by examining matched biopsy and prostatectomy samples. Design, setting, and participants: Patients who underwent radical prostatectomy at The Princess Margaret Cancer Centre between January 2015 and December 2022 and had cribriform morphology and/or IDC in the surgical specimen were included in the study. Outcome measurements and statistical analysis: We used detection sensitivity to evaluate the level of agreement between biopsy and prostatectomy samples regarding the presence of cribriform morphology and IDC. Results and limitations: Of the 287 men who underwent radical prostatectomy, 241 (84%) had cribriform morphology and 161 (56%) had IDC on final pathology. The sensitivity of prostate biopsy, using radical prostatectomy as the reference, was 42.4% (95% confidence interval [CI] 36–49%) for detection of cribriform morphology and 44.1% (95% CI 36–52%) for detection of IDC. The sensitivity of prostate biopsy for detection of either IDC or cribriform morphology was 52.5% (95% CI 47–58%). Among patients who underwent multiparametric magnetic resonance imaging–guided biopsies, the sensitivity was 54% (95% CI 39–68%) for detection of cribriform morphology and 37% (95% CI 19–58%) for detection of IDC. Conclusions: Biopsy has low sensitivity for detecting cribriform morphology and IDC. These limitations should be incorporated into clinical decision-making. Biomarkers for better detection of these histological patterns are needed. Patient summary: Prostate biopsy is not an accurate method for detecting two specific types of prostate cancer cells, called cribriform pattern and intraductal prostate cancer, which are associated with unfavorable prognosis.proofepub_ahead_of_prin

Wandel des wissenschaftlichen Publizierens – eine Heuristik zur Analyse rezenter Wandlungsprozesse

Taubert NC, Weingart P. Wandel des wissenschaftlichen Publizierens – eine Heuristik zur Analyse rezenter Wandlungsprozesse. In: Weingart P, Taubert N, Berlin-Brandenburgische Akademie der Wissenschaften, eds. Wissenschaftliches Publizieren - Zwischen Digitalisierung, Leistungsmessung, Ökonomisierung und medialer Beobachtung. Berlin: De Gruyter Akademie Forschung; 2016: 3-38