Movilidad sostenible en entornos turísticos. Singularidades y medidas

Las medidas orientadas a la movilidad sostenible se encuentran generalmente bien desarrolladas, al menos en el plano teórico, para entornos urbanos convencionales, esto es, para ciudades donde la movilidad sigue una pauta esencialmente recurrente y vinculada a motivos como el trabajo y el estudio. Sin embargo, en entornos donde el turismo es una componente predominante, la movilidad es claramente diferente. Las motivaciones de los viajes son diferentes, la valoración del tiempo es diferente, las pautas espacio-temporales son diferentes. Por tanto, las medidas para la sostenibilidad de la movilidad han de ser diferentes

Estudio del comportamiento y los habitos de compra de los clientes de una multitienda, mediante el uso de tecnicas de mineria de datos

133 p.La industria del Retail en Chile ha experimentado un significativo crecimiento durante los últimos años, posicionándose en un mercado atractivo y competitivo en donde tiendas por departamento como Multihogar, buscan la diferenciación en Curicó. Para lograr este objetivo, herramientas propias de Minería de Datos son utilizadas para el desarrollo de tres estudios, que en base a información transaccional de los años 2006 y 2007, pretenden la identificación de productos complementarios ofrecidos en la tienda, con el objetivo de reconocer los hábitos de compra de los consumidores. Además, se genera un modelo de migración del cliente con el propósito de detectar de manera anticipada, que clientes son propensos a terminar su relación con la empresa, pronosticándose que un 10,7% de los clientes abandonan la tienda al cabo de 3 meses. Finalmente, se desarrolla un estudio para determinar el Valor de Vida del Cliente, para el cual se establece que los consumidores que visitan la tienda más de dos veces y realizan compras de $ 123.000 mensuales en promedio, corresponden a los clientes más rentables para la empresa. Posteriormente los modelos generados son validados en base a información transaccional del año 2008 para luego presentar conclusiones que permitan a la empresa tomar medidas futuras en base al conocimiento adquirido

Enseñar Ciencias Sociales con Fuentes Primarias. Reflexiones para "humanizar" la Historia

Este trabajo recoge una reflexión que contribuya a la renovación de la enseñanza de contenidos históricos en Educación Secundaria y Bachillerato. Para ello, proponemos resituar a los actores históricos, verdaderos protagonistas de los aconteceres del pasado, en el centro del proceso de enseñanza-aprendizaje de la Historia a partir del uso eficaz de fuentes documentales originales.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Creencia y creación en Unamuno

Esta tesis doctoral estudia las nociones de creencia y creación en Unamuno. Para ello, en primer lugar, se realiza un breve recorrido por su biografía destacando los momentos más relevantes para la formación de su estilo filosófico. En segundo lugar, se estudian cuáles son las principales ideas de su forma de interpretar la religiosidad, así como hasta qué punto estas ideas llegaron a permear en su discurso vital. Después, se analizan algunas de las ideas filosóficas más relevantes de Unamuno y cómo, a través de ellas, vehicula una manera determinada de entender a los personajes de ficción. Más adelante, se pasa a investigar las nivolas donde los conceptos de creencia y creación tienen más relevancia. Por último, se ofrecen algunas conclusiones a la luz de los textos analizados.<br /

Statistical analysis of an experimental database on residual flexural strengths of fiber reinforced concretes: performance-based equations

The postcracking capacity of fiber reinforced concrete (FRC) mainly depends on the content, material, and geometry of the fibers considered. Even though the general influence of these factors on FRC behavior has been extensively addressed, the uncertainty of the FRC performance prediction along with the variability of the results still poses a challenging issue that needs to be solved to encourage the use of FRC for design and construction purposes. In this line, a database including the results of the flexural residual strength obtained from different experimental programs combined with the results of previous studies has been gathered and analyzed herein to obtain general correlations and trends providing additional information about the influence of the fibers in FRC behavior, these meant to serve for initial design stages (e.g., make decisions on the type and amount of fibers based on technical and economical requirements). The results are analyzed distinguishing between the fiber material, the fiber shape, the aspect ratio and tensile strength. The results presented herein may provide valuable information on the initial prediction of the residual strength of FRC to fully take advantage of the mechanical properties of the material.The authors from UPC wish to express their acknowledgment to the Ministry of Economy, Industry and Competitiveness of Spain for the financial support received under the scope of the projects BIA2016-78742-C2-1-R and PID2019-108978RB-C32.Peer ReviewedPostprint (published version

Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO

Aneurysm; Aortic diseases; Marfan syndromeAneurisma; Malalties aòrtiques; Síndrome de MarfanAneurisma; Enfermedades aórticas; Síndrome de MarfanThoracic aortic aneurysm, as occurs in Marfan syndrome, is generally asymptomatic until dissection or rupture, requiring surgical intervention as the only available treatment. Here, we show that nitric oxide (NO) signaling dysregulates actin cytoskeleton dynamics in Marfan Syndrome smooth muscle cells and that NO-donors induce Marfan-like aortopathy in wild-type mice, indicating that a marked increase in NO suffices to induce aortopathy. Levels of nitrated proteins are higher in plasma from Marfan patients and mice and in aortic tissue from Marfan mice than in control samples, indicating elevated circulating and tissue NO. Soluble guanylate cyclase and cGMP-dependent protein kinase are both activated in Marfan patients and mice and in wild-type mice treated with NO-donors, as shown by increased plasma cGMP and pVASP-S239 staining in aortic tissue. Marfan aortopathy in mice is reverted by pharmacological inhibition of soluble guanylate cyclase and cGMP-dependent protein kinase and lentiviral-mediated Prkg1 silencing. These findings identify potential biomarkers for monitoring Marfan Syndrome in patients and urge evaluation of cGMP-dependent protein kinase and soluble guanylate cyclase as therapeutic targets

Analysis of the interaction between tryptophan-related compounds and ATP-binding cassette transporter G2 (ABCG2) using targeted metabolomics

ATP-binding cassette transporter G2 (ABCG2) is involved in the secretion of several compounds in milk. The in vitro and in vivo interactions between tryptophan-related compounds and ABCG2 were investigated. The tryptophan metabolome was determined by liquid chromatography-tandem mass spectrometry in milk and plasma from wild-type and Abcg2-/- mice as well as dairy cows carrying the ABCG2 Y581S polymorphism (Y/S) and noncarrier animals (Y/Y). The milk-to-plasma ratios of tryptophan, kynurenic acid, kynurenine, anthranilic acid, and xanthurenic acid were higher in wild-type mice than in Abcg2-/- mice. The ratio was 2-fold higher in Y/S than in Y/Y cows for kynurenine. In vitro transport assays confirmed that some of these compounds were in vitro substrates of the transporter and validated the differences observed between the two variants of the bovine protein. These findings show that the secretion of metabolites belonging to the kynurenine pathway into milk is mediated by ABCG2.SIThis study was supported by the research projects AGL2015-65626-R (MINECO/FEDER, UE) and RTI2018-100903-B-I00 (AEI/FEDER, UE), predoctoral grants from the Ministry of Economy, Industry, and Competitiveness (BES-2016-077235 grant to AMGL), and grants from the Spanish Ministry of Education, Culture, and Sport (FPU14/05131 grant to DGM). Funding was also obtained from a research contract for OJP from the Spanish Health Institute Carlos III (CPII16/00027

Quality Analysis of YouTube Videos Presenting Pelvic Floor Exercises after Prostatectomy Surgery

Background: Prostate cancer (PC) is a major cause of disease and mortality among men. Surgical treatment involving the removal of the prostate may result in temporary or permanent erectile dysfunction (ED) and urinary incontinence (UI), with considerable impact on quality of life. Pelvic floor muscle training (PFMT) is one of the recommended techniques for the prevention, treatment, and rehabilitation of postoperative complications. The aim of this observational study was to assess the quality of YouTube videos—accessible to any patient—related to exercises after prostatectomy surgery. Methods: A systematic search was performed on YouTube on 24 September 2020. One hundred and fifty videos were selected and analyzed. Two statistical analyses were conducted based on machine-learning techniques, and videos were classified as ‘Relevant’ or ‘Non-Relevant’ using Principal Component Analysis (PCA) models. Two reviewers conducted independent analyses. Inter-observer agreement and individual correlations of video data were evaluated with the Intraclass Correlation Coefficient (ICC). Information quality, reliability, and accuracy were measured using the DISCERN Scale and Global Quality Score (GQS), while video popularity was evaluated using the Video Power Index (VPI). Results: DISCERN scored a mean of 3.35 and GQS scored 3.38. Average number of views was 124,354, mean duration was 14:42 min, mean days online was 1777, mean view ratio was 138.30, mean Likes was 1082, mean Dislikes was 68.58, and mean VPI was 92.28. Conclusions: The quality of the videos available on YouTube regarding the recommended pelvic floor exercises in PC surgery, according to the scores obtained, is High. Educational and health institutions, health professionals, government health authorities, and policy makers need to be involved in the proper development of policies to improve the information available on the web in order to have a positive impact on the healthy behavior of the population

MoBioTools: a toolkit to setup quantum mechanics/molecular mechanics calculations

We present a toolkit that allows for the preparation of QM/MM input files from a conformational ensemble of molecular geometries. The package is currently compatible with trajectory and topology files in Amber, CHARMM, GROMACS and NAMD formats, and has the possibility to generate QM/MM input files for Gaussian (09 and 16), Orca (≥4.0), NWChem and (Open)Molcas. The toolkit can be used in command line, so that no programming experience is required, although it presents some features that can also be employed as a python application programming interface. We apply the toolkit in four situations in which different electronic-structure properties of organic molecules in the presence of a solvent or a complex biological environment are computed: the reduction potential of the nucleobases in acetonitrile, an energy decomposition analysis of tyrosine interacting with water, the absorption spectrum of an azobenzene derivative integrated into a voltage-gated ion channel, and the absorption and emission spectra of the luciferine/luciferase complex. These examples show that the toolkit can be employed in a manifold of situations for both the electronic ground state and electronically excited states. It also allows for the automatic correction of the active space in the case of CASSCF calculations on an ensemble of geometries, as it is shown for the azobenzene derivative photoswitch caseSpanish Ministry of Science and Innovation; MCIN/AEI, Grant/Award Numbers: PID2020-117806GA-I00, PID2019-110091GB-I00; María de Maeztu, Grant/Award Number: CEX2018-000805-M; Comunidad de Madrid, Grant/Award Number: 2018-T1/BMD-10261; Xunta de Galicia, Grant/Award Number: GRC2019/24; the European Social Fund; Spanish Ministry of Education and Vocational Training, Grant/Award Number: FPU19/02292; Universidade de Vigo, Grant/Award Number: PREUVIGO-21; Universidad Autonoma de Madri