1,371 research outputs found

    Scattering of a Long Cosmic String by a Rotating Black Hole

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    The scattering of a straight, infinitely long string by a rotating black hole is considered. We assume that a string is moving with velocity v and that initially the string is parallel to the axis of rotation of the black hole. We demonstrate that as a result of scattering, the string is displaced in the direction perpendicular to the velocity by an amount kappa(v,b), where b is the impact parameter. The late-time solution is represented by a kink and anti-kink, propagating in opposite directions at the speed of light, and leaving behind them the string in a new ``phase''. We present the results of the numerical study of the string scattering and their comparison with the weak-field approximation, valid where the impact parameter is large, b/M >> 1, and also with the scattering by a non-rotating black hole which was studied in earlier works.Comment: 27 pages, 14 figures, to be published in Classical and Quantum Gravit

    Pyrantel Pamoate in Roundworm Infestations

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    A controlled single-blind trial was carried out to compare the effect of single-dose therapy with pyrantel pamoate (Combantrin) and piperazine citrate in children infested with Ascaris lumbricoides. Fifty-six children were treated. Pyrantel pamoate was 96,4% effective and piperazine c::itrate 82,1% effective in eradicating Ascaris lumbricoides. ova from 3 consecutive stools taken on the 7th, 8th and 9th days after treatment. If results of stool examination on the 9th day only are considered, pyrantel pamoate was 100% effective and piperazine citrate was 89,3% effective. S. Afr. Med. J., 47, 91 (1973

    Die meting van die verband tussen geslag en konformiteit as groepdinamiese veranderlikes

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    The original publication is available at http://www.sajip.co.zaThe amount and kind of conformity induced by group pressure depend upon the nature of the situation. The nature of the group and the characteristics of the individual. In this particular study the experimental measurement of conformity developed by Asch and Crutchfield was repeated. Confirmation was found that sex operates as one of the determinants of conformity.Publishers' Versio

    Review of once-monthly oral ibandronate and the use thereof

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    An advisory board meeting of key opinion leaders was held in 2015 to discuss the clinical data on oral ibandronate in the treatment of postmenopausal osteoporosis.Boniva 150 mg (ibandronate) oral once-monthly is indicated for the treatment of osteoporosis in postmenopausal women, in order to reduce the risk of vertebral fractures.

    Highly syntenic and yet divergent: a tale of two Theilerias

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    The published genomic sequences of the two major host-transforming Theileria species of cattle represent a rich resource of information that has allowed novel bioinformatic and experimental studies into these important apicomplexan parasites. Since their publication in 2005, the genomes of T. annulata and T. parva have been utilised for a diverse range of applications, ranging from candidate antigen discovery to the identification of genetic markers for population analysis. This has led to advancements in the quest for a sub-unit vaccine, while providing a greater understanding of variation among parasite populations in the field. The unique ability of these Theileria species to induce host cell transformation is the subject of considerable scientific interest and the availability of full genomic sequences has provided new insights into this area of research. This article reviews the data underlying published comparative analyses, focussing on the general features of gene expression, the major Tpr/Tar multi-copy gene family and a re-examination of the predicted macroschizont secretome. Codon usage between the Theileria species is reviewed in detail, as this underpins ongoing comparative studies investigating selection at the intra- and inter-species level. The TashAT/TpshAT family of genes, conserved between T. annulata and T. parva, encodes products targeted to the host nucleus and has been implicated in contributing to the transformed bovine phenotype. Species-specific expansion and diversification at this critical locus is discussed with reference to the availability, in the near future, of genomic datasets which are based on non-transforming Theileria species

    Persistent pain following ankle sprain: Bilateral accessory soleus muscles

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    Persistent pain following ankle sprain remains a difficult diagnostic and management dilemma. We report a 22 year old rugby player who presented with a persistent painful left ankle following a minor ankle sprain. After examination and imaging investigations, a symptomatic accessory soleus muscle was diagnosed on the left ankle, and an asymptomatic accessory soleus muscle on the right

    A review of school nutrition interventions globally as an evidence base for the development of the HealthKick programme in the Western Cape, South Africa

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    Aim: The aim of this study was to review all school interventions having a nutrition component, published in peer-reviewed literature between 1995 and 2006, and to document activities that were successful as well as those that were possible barriers in order to develop a best practice school intervention for the Western Cape Province, South Africa.Methodology: A systematic review of school studies revealed 85 interventions that complied with the predetermined search criteria. The following outcome measures were considered in the evaluation of the interventions: (i) changes in nutritional knowledge, attitudes and  selfefficacy and stage of change; (ii) changes in dietary behaviours; (iii) changes in clinical/physical markers such as body weight or body mass index, blood pressure or serum cholesterol concentrations; and (iv) process and/or policy outcomes.Results: Key success factors of school-based interventions appeared to be the following: A nutrition-based curriculum offered at school by trained teachers generally improved behavioural outcomes. A physical activity programme and parental component were associated with most of the best practice clinical and behavioural outcomes. Furthermore, all best practice studies were grounded on a firm theory of behaviour, such as social cognitive, social marketing or stages of change. Most of the interventions that included a food service component had best practice behavioural outcomes.Conclusions: Numerous school-based nutrition interventions have shown significant improvements in children’s nutritional behaviours. Consequently, it is necessary to plan programmes based on existing evidence of best practice. The lessons learnt from this review have beenapplied in the development of the HealthKick programme initiated in  schools in the Western Cape in 2007

    Sacroiliac tuberculosis masquerading as mechanical lower back pain in a collegiate basketball athlete: a case presentation

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    Background: Sacroiliac tuberculosis is a rare condition for which early diagnosis and effective management frequently proves challenging. This report describes a case that was initially overlooked due to its presentation and unreported constitutional symptoms.Aim: To alert clinicians about skeletal tuberculosis, an often neglected diagnostic differential, which requires a high index of clinical suspicion, especially for patients from endemic areas.Findings: This patient’s presentation (sports injury) and unreported constitutional symptoms resulted in a delay in the diagnosis and initial institution of treatment.Implications: This report illustrates the importance of specifically asking about constitutional symptoms, even in sports injury settings and being mindful of infectious diseases or other chronic medical conditions, which may masquerade as common sports injuries.Keywords: skeletal tuberculosis, sacroiliitis, hip pai

    Increase in childhood asthma admissions in an urbanising population

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    Objective. In South Africa, rapid urbanisation has increased the risk of childhood asthma. This report reviews the pattern of asthma admissions to the Paediatric Department of Ga-Rankuwa Hospital, South Africa, from 1986 to 1996. Design. Inpatient admission data were reviewed for 1986- 1996. A detailed analysis of the records of asthma patients admitted between 1992 and 1996 was done. Outpatient data were reviewed from 1992.Setting. Ga-Rankuwa Hospital, situated on the border of the Gauteng and orth West provinces of South Africa and serving a large black population in various stages of urbanisation.Main outcome measures. Trends in admission numbers and demographic characteristics.Results. Asthma admissions were 2.5 times higher in 1996 than 1986. The greatest increase in admissions was in the 1 - 47-month age group. The male to female ratio was 1.5:1. More patients came from urban than from rural areas. Admissions peaked during the summer. Re-admissions occurred most frequently within 3 months of the first admission.Conclusion. Paediatric asthma admissions have shown an increase in the past decade. This may be associated with changes in the environment of the community. There is a need for preventive programmes for asthma at community and national level

    Compounded laxative formulations for substituting phenolphthalein with sennosides A & B in solid dosage forms

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    Purpose: Following the discovery of the carcinogenicity of phenolphthalein and the subsequent ban of this compound in several countries this study was undertaken to develop compounded formulations of laxative products containing the stimulant laxatives sennosides A and B. Methods: DSC and HPLC analysis was used to determine the compatibility of sennosides with commonly used excipients before compounding capsules, tablets and effervescent tablets containing sennosides A & B. The physical and chemical stability and release properties of these dosage forms were determined for 12 weeks at increased temperature and relative humidity. Results: Sennosides A & B were compatible with a wide variety of powdered excipients. However, these were incompatible with propyl paraben, sodium carbonate, stearic acid, citric acid, PEG, and sugar derivatives such as lactose, glucose and sorbitol when granulated with water. Not withstanding these interactions, it was possible to compound simple capsule, tablet and even an effervescent tablet formulations containing sennosides A & B that complied with pharmacopeial specifications. However, all these formulations were sensitive to moisture because when stored at increased temperature and relative humidity, disintegration times increased and dissolution rates decreased. Conclusion: Based on compatibility and stability studies simple, stable and elegant solid dosage forms containing sennosides A & B were compounded that can be used to replace phenolphthalein in a variety of solid dosage forms. Keywords: Compounding; Sennosides A & B; Phenolphthalein replacement; Drug-Excipient Compatibility > Tropical Journal of Pharmaceutical Research Vol. 3 (1) 2004: pp. 265-27
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