Normal traces and applications to continuity equations on bounded domains

In this work, we study several properties of the normal Lebesgue trace of vector fields introduced by the second and third author in [18] in the context of the energy conservation for the Euler equations in Onsager-critical classes. Among several properties, we prove that the normal Lebesgue trace satisfies the Gauss-Green identity and, by providing explicit counterexamples, that it is a notion sitting strictly between the distributional one for measure-divergence vector fields and the strong one for $BV$ functions. These results are then applied to the study of the uniqueness of weak solutions for continuity equations on bounded domains, allowing to remove the assumption in [15] of global $BV$ regularity up to the boundary, at least around the portion of the boundary where the characteristics exit the domain or are tangent. The proof relies on an explicit renormalization formula completely characterized by the boundary datum and the positive part of the normal Lebesgue trace. In the case when the characteristics enter the domain, a counterexample shows that achieving the normal trace in the Lebesgue sense is not enough to prevent non-uniqueness, and thus a $BV$ assumption seems to be necessary for the uniqueness of weak solutions

High-resolution structure of an atypical α-phosphoglucomutase related to eukaryotic phosphomannomutases

The first structure of a bacterial α-phosphoglucomutase with an overall fold similar to eukaryotic phosphomannomutases is reported. Unlike most α-phosphoglucomutases within the α-D-phosphohexomutase superfamily, it belongs to subclass IIb of the haloacid dehalogenase superfamily (HADSF). It catalyzes the reversible conversion of α-glucose 1-phosphate to glucose 6-phosphate. The crystal structure of α-phosphoglucomutase from Lactococcus lactis (APGM) was determined at 1.5 Å resolution and contains a sulfate and a glycerol bound at the enzyme active site that partially mimic the substrate. A dimeric form of APGM is present in the crystal and in solution, an arrangement that may be functionally relevant. The catalytic mechanism of APGM and its strict specificity towards α-glucose 1-phosphate are discussed.Diamond Light Source

Human parvovirus PARV4 DNA in tissues from adult individuals: a comparison with human parvovirus B19 (B19V)

<p>Abstract</p> <p>Background</p> <p>PARV4 is a new member of the Parvoviridae family not closely related to any of the known human parvoviruses. Viremia seems to be a hallmark of PARV4 infection and viral DNA persistence has been demonstrated in a few tissues. Till now, PARV4 has not been associated with any disease and its prevalence in human population has not been clearly established. This study was aimed to assess the tissue distribution and the ability to persist of PARV4 in comparison to parvovirus B19 (B19V).</p> <p>Results</p> <p>PARV4 and B19V DNA detection was carried out in various tissues of individuals without suspect of acute viral infection, by a real time PCR and a nested PCR, targeting the ORF2 and the ORF1 respectively. Low amount of PARV4 DNA was found frequently (>40%) in heart and liver of adults individuals, less frequently in lungs and kidneys (23,5 and 18% respectively) and was rare in bone marrow, skin and synovium samples (5,5%, 4% and 5%, respectively). By comparison, B19V DNA sequences were present in the same tissues with a higher frequency (significantly higher in myocardium, skin and bone marrow) except than in liver where the frequency was the same of PARV4 DNA and in plasma samples where B19V frequency was significantly lower than that of PARV4</p> <p>Conclusions</p> <p>The particular tropism of PARV4 for liver and heart, here emerged, suggests to focus further studies on these tissues as possible target for viral replication and on the possible role of PARV4 infection in liver and heart diseases. Neither bone marrow nor kidney seem to be a common target of viral replication.</p

Pesquisa e ensino do português no âmbito acadêmico italiano

Nesse número temático da Revista L&amp;L, destacam-se dezoito artigos que rearticulam dois binômios conceituais interligados e em combinações muitas vezes originais e de forma alguma tidas como certas, demonstrando ainda mais não apenas o inesgotável potencial de linhas analíticas ligadas tanto à pesquisa linguística aplicada ao ensino da língua portuguesa, quanto à pesquisa ligada à didática. De fato, essas contribuições evidenciam a fértil e reconhecida capacidade dos autores deste volume em conseguir conjugar a tradição com a inovação e a tentativa de rever, revolucionar visões e conceitos difusos e aceitos através de pesquisas inovadoras que nos levam a refletir muito sobre o objeto língua portuguesa. No entanto, gostaríamos de agradecer a todos aqueles que o tornaram possível, participando com suas contribuições e, em particular, os keynote speakers do IV Congresso Internacional “O ensino do português brasileiro na universidade italiana” e do I e do II Congresso Internacional “Dia Mundial da língua portuguesa”: Dinah Callou, professora emérita da Universidade Federal do Rio de Janeiro; Maria Eugênia Lamoglia Duarte, professora titular da Universidade Federal do Rio de Janeiro, e o professor Carlos Alberto Faraco, professor emérito da Universidade Federal do Paraná. Por fim, gostaríamos de dedicar esse número especial a um amigo, a um irmão, a um estudioso excelente, Salvador Pippa, que nos deixou cedo demais, mas que continua presente nas nossas lembranças com o seu sorriso e a sua alma gentil

Part I – Língua e Linguística

Part

PART II – Língua e Didática do PLE

Part I