15 research outputs found

    Absorption and unbounded superradiance in a static regular black hole spacetime

    Get PDF
    Regular black holes (RBHs)—geometries free from curvature singularities—arise naturally in theories of nonlinear electrodynamics. Here we study the absorption and superradiant amplification of a monochromatic planar wave in a charged, massive scalar field impinging on the electrically charged Ayón-Beato-García (ABG) RBH. Comparisons are drawn with absorption and superradiance for the Reissner-Nordström (RN) black hole in linear electrodynamics. We find that, in a certain parameter regime, the ABG absorption cross section is negative, due to superradiance, and moreover it is unbounded from below as the momentum of the wave approaches zero; this phenomenon of “unbounded superradiance” is absent in the RN case. We show how the parameter space can be divided into regions, using the bounded/unbounded and absorption/amplification boundaries. After introducing a high-frequency approximation based on particle trajectories, we calculate the absorption cross section numerically, via the partial-wave expansion, as a function of wave frequency, and we present a gallery of results. The cross section of the ABG RBH is found to be larger (smaller) than in the RN case when the field charge has the same (opposite) sign as the black hole charge. We show that it is possible to find “mimics”: situations in which the cross sections of both black holes are very similar. We conclude with a discussion of unbounded superradiance and superradiant instabilities

    Differential Expression Of Hdac3, Hdac7 And Hdac9 Is Associated With Prognosis And Survival In Childhood Acute Lymphoblastic Leukaemia: Research Paper

    No full text
    Altered expression of histone deacetylases (HDACs) is a common feature in several human malignancies and may represent an interesting target for cancer treatment, including haematological malignancies. We evaluated the mRNA gene expression profile of 12 HDAC genes by quantitative real-time polymerase chain reaction in 94 consecutive childhood acute lymphoblastic leukaemia (ALL) samples and its association with clinical/biological features and survival. ALL samples showed higher expression levels of HDAC2, HDAC3, HDAC8, HDAC6 and HDAC7 when compared to normal bone marrow samples. HDAC1 and HDAC4 showed high expression in T-ALL and HDAC5 was highly expressed in B-lineage ALL. Higher than median expression levels of HDAC3 were associated with a significantly lower 5-year event-free survival (EFS) in the overall group of patients (P = 0·03) and in T-ALL patients (P = 0·01). HDAC7 and HADC9 expression levels higher than median were associated with a lower 5-year EFS in the overall group (P = 0·04 and P = 0·003, respectively) and in B-lineage CD10-positive patients (P = 0·009 and P = 0·005, respectively). Our data suggest that higher expression of HDAC7 and HDAC9 is associated with poor prognosis in childhood ALL and could be promising therapeutic targets for the treatment of refractory childhood ALL. © 2010 Blackwell Publishing Ltd.1506665673Acharya, M.R., Sparreboom, A., Venitz, J., Figg, W.D., Rational development of histone deacetylase inhibitors as anticancer agents: A review (2005) Molecular Pharmacology, 68, pp. 917-932Altucci, L., Minucci, S., Epigenetic therapies in haematological malignancies: Searching for true targets (2009) European Journal of Cancer, 45, pp. 1137-1145Bakin, R.E., Jung, M.O., Cytoplasmic sequestration of HDAC7 from mitochondrial and nuclear compartments upon initiation of apoptosis (2004) Journal of Biological Chemistry, 279, pp. 51218-51225Baylin, S.B., Ohm, J.E., Epigenetic gene silencing in cancer - A mechanism for early oncogenic pathway addiction? (2006) Nature Reviews. Cancer, 6, pp. 107-116Bernstein, B.E., Meissner, A., Lander, E.S., The mammalian epigenome (2007) Cell, 128, pp. 669-681Blum, K.A., Advani, A., Fernandez, L., Van Der Jagt, R., Brandwein, J., Kambhampati, S., Kassis, J., Byrd, J.C., Phase II study of the histone deacetylase inhibitor MGCD0103 in patients with previously treated chronic lymphocytic leukaemia (2009) British Journal Haematology, 147, pp. 507-514Bradbury, C.A., Khanim, F.L., Hayden, R., Bunce, C.M., White, D.A., Drayson, M.T., Craddock, C., Turner, B.M., Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors (2005) Leukemia, 19, pp. 1751-1759Brandalise, S.R., Pinheiro, V.R., Aguiar, S.S., Matsuda, E.I., Otubo, R., Yunes, J.A., Pereira, W.V., Viana, M.B., Benefits of the intermittent use of 6-mercaptopurine and methotrexate in maintenance treatment for low-risk acute lymphoblastic leukemia in children: Randomized trial from the Brazilian Childhood Cooperative Group - Protocol ALL-99 (2010) Journal of Clinical Oncology, , in press. doi/10.1200/JCO.2009.25.6115Byrd, J.C., Marcucci, G., Parthun, M.R., Xiao, J.J., Klisovic, R.B., Moran, M., Lin, T.S., Grever, M.R., A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia (2005) Blood, 105, pp. 959-967Choi, Y.W., Bae, S.M., Kim, Y.W., Lee, H.N., Kim, Y.W., Park, T.C., Ro, D.Y., Ahn, W.S., Gene expression profiles in squamous cell cervical carcinoma using array-based comparative genomic hybridization analysis (2007) International Journal of Gynecological Cancer, 17, pp. 687-696Cortez, M.A., Scrideli, C.A., Yunes, J.A., Valera, E.T., Toledo, S.R., Pavoni-Ferreira, P.C., Lee, M.L., Tone, L.G., MRNA expression profile of multidrug resistance genes in childhood acute lymphoblastic leukemia. Low expression levels associated with a higher risk of toxic death (2009) Pediatric Blood & Cancer, 53, pp. 996-1004Cress, W.D., Seto, E., Histone deacetylases, transcriptional control, and cancer (2000) Journal of Cellular Physiology, 184, pp. 1-16Ducasse, M., Brown, M.A., Epigenetic aberrations and cancer (2006) Molecular Cancer, 5, p. 60Esau, C., Boes, M., Youn, H.D., Tatterson, L., Liu, J.O., Chen, J., Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells (2001) Journal of Experimental Medicine, 194, pp. 1449-1459Gallinari, P., Di Marco, S., Jones, P., Pallaoro, M., Steinkuhler, C., HDACs, histone deacetylation and gene transcription: From molecular biology to cancer therapeutics (2007) Cell Research, 17, pp. 195-211Galm, O., Herman, J.G., Baylin, S.B., The fundamental role of epigenetics in hematopoietic malignancies (2006) Blood Reviews, 20, pp. 1-13Garcia-Manero, G., Assouline, S., Cortes, J., Estrov, Z., Kantarjian, H., Yang, H., Newsome, W.M., Minden, M., Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia (2008) Blood, 112, pp. 981-989Gloghini, A., Buglio, D., Khaskhely, N.M., Georgakis, G., Orlowski, R.Z., Neelapu, S.S., Carbone, A., Younes, A., Expression of histone deacetylases in lymphoma: Implication for the development of selective inhibitors (2009) British Journal Haematology, 147, pp. 515-525Glozak, M.A., Seto, E., Histone deacetylases and cancer (2007) Oncogene, 26, pp. 5420-5432Gruffat, H., Manet, E., Sergeant, A., MEF2-mediated recruitment of class II HDAC at the EBV immediate early gene BZLF1 links latency and chromatin remodeling (2002) EMBO Reports, 3, pp. 141-146Holleman, A., Cheok, M.H., Den Boer, M.L., Yang, W., Veerman, A.J., Kazemier, K.M., Pei, D., Evans, W.E., Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment (2004) New England Journal of Medicine, 351, pp. 533-542Holliday, R., Epigenetics: A historical overview (2006) Epigenetics, 1, pp. 76-80Karagianni, P., Wong, J., HDAC3: Taking the SMRT-N-CoRrect road to repression (2007) Oncogene, 26, pp. 5439-5449Kato, H., Tamamizu-Kato, S., Shibasaki, F., Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity (2004) Journal of Biological Chemistry, 279, pp. 41966-41974Kim, Y., Tian, M., NF-kappaB family of transcription factor facilitates gene conversion in chicken B cells (2009) Molecular Immunology, 46, pp. 3283-3291Kim, D.H., Kim, M., Kwon, H.J., Histone deacetylase in carcinogenesis and its inhibitors as anti-cancer agents (2003) Journal of Biochemistry and Molecular Biology, 36, pp. 110-119Klimek, V.M., Fircanis, S., Maslak, P., Guernah, I., Baum, M., Wu, N., Panageas, K., Nimer, S.D., Tolerability, pharmacodynamics, and pharmacokinetics studies of depsipeptide (romidepsin) in patients with acute myelogenous leukemia or advanced myelodysplastic syndromes (2008) Clinical Cancer Research, 14, pp. 826-832Krusche, C.A., Wulfing, P., Kersting, C., Vloet, A., Bocker, W., Kiesel, L., Beier, H.M., Alfer, J., Histone deacetylase-1 and -3 protein expression in human breast cancer: A tissue microarray analysis (2005) Breast Cancer Research and Treatment, 90, pp. 15-23Lane, A.A., Chabner, B.A., Histone deacetylase inhibitors in cancer therapy (2009) Journal of Clinical Oncology, 27, pp. 5459-5468Livak, K.J., Schmittgen, T.D., Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method (2001) Methods, 25, pp. 402-408Lu, Q., Qiu, X., Hu, N., Wen, H., Su, Y., Richardson, B.C., Epigenetics, disease, and therapeutic interventions (2006) Ageing Research Reviews, 5, pp. 449-467Lucio-Eterovic, A.K., Cortez, M.A., Valera, E.T., Motta, F.J., Queiroz, R.G., MacHado, H.R., Carlotti Jr., C.G., Tone, L.G., Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: Class II and IV are hypoexpressed in glioblastomas (2008) BMC Cancer, 8, p. 243Mann, B.S., Johnson, J.R., Cohen, M.H., Justice, R., Pazdur, R., FDA approval summary: Vorinostat for treatment of advanced primary cutaneous T-cell lymphoma (2007) Oncologist, 12, pp. 1247-1252Marks, P., Rifkind, R.A., Richon, V.M., Breslow, R., Miller, T., Kelly, W.K., Histone deacetylases and cancer: Causes and therapies (2001) Nature Reviews. Cancer, 1, pp. 194-202Marquard, L., Gjerdrum, L.M., Christensen, I.J., Jensen, P.B., Sehested, M., Ralfkiaer, E., Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous T-cell lymphoma (2008) Histopathology, 53, pp. 267-277Marquard, L., Poulsen, C.B., Gjerdrum, L.M., De Nully Brown, P., Christensen, I.J., Jensen, P.B., Sehested, M., Ralfkiaer, E., Histone deacetylase 1, 2, 6 and acetylated histone H4 in B- and T-cell lymphomas (2009) Histopathology, 54, pp. 688-698Matthews, S.A., Liu, P., Spitaler, M., Olson, E.N., McKinsey, T.A., Cantrell, D.A., Scharenberg, A.M., Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes (2006) Molecular and Cellular Biology, 26, pp. 1569-1577Melnick, A., Licht, J.D., Histone deacetylases as therapeutic targets in hematologic malignancies (2002) Current Opinion in Hematology, 9, pp. 322-332Minucci, S., Pelicci, P.G., Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer (2006) Nature Reviews. Cancer, 6, pp. 38-51Nakagawa, M., Oda, Y., Eguchi, T., Aishima, S., Yao, T., Hosoi, F., Basaki, Y., Tsuneyoshi, M., Expression profile of class i histone deacetylases in human cancer tissues (2007) Oncology Reports, 18, pp. 769-774Olsen, E.A., Kim, Y.H., Kuzel, T.M., Pacheco, T.R., Foss, F.M., Parker, S., Frankel, S.R., Duvic, M., Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma (2007) Journal of Clinical Oncology, 25, pp. 3109-3115Osada, H., Tatematsu, Y., Saito, H., Yatabe, Y., Mitsudomi, T., Takahashi, T., Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients (2004) International Journal of Cancer, 112, pp. 26-32Ouaissi, M., Sielezneff, I., Silvestre, R., Sastre, B., Bernard, J.P., Lafontaine, J.S., Payan, M.J., Ouaissi, A., High histone deacetylase 7 (HDAC7) expression is significantly associated with adenocarcinomas of the pancreas (2008) Annals of Surgical Oncology, 15, pp. 2318-2328Petrie, K., Guidez, F., Howell, L., Healy, L., Waxman, S., Greaves, M., Zelent, A., The histone deacetylase 9 gene encodes multiple protein isoforms (2003) Journal of Biological Chemistry, 278, pp. 16059-16072Rao, S., Karray, S., Gackstetter, E.R., Koshland, M.E., Myocyte enhancer factor-related B-MEF2 is developmentally expressed in B cells and regulates the immunoglobulin J chain promoter (1998) Journal of Biological Chemistry, 273, pp. 26123-26129Romanski, A., Bacic, B., Bug, G., Pfeifer, H., Gul, H., Remiszewski, S., Hoelzer, D., Ottmann, O.G., Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia (2004) Haematologica, 89, pp. 419-426Ropero, S., Esteller, M., The role of histone deacetylases (HDACs) in human cancer (2007) Molecular Oncology, 1, pp. 19-25Ross, M.E., Zhou, X., Song, G., Shurtleff, S.A., Girtman, K., Williams, W.K., Liu, H.C., Downing, J.R., Classification of pediatric acute lymphoblastic leukemia by gene expression profiling (2003) Blood, 102, pp. 2951-2959Sakajiri, S., Kumagai, T., Kawamata, N., Saitoh, T., Said, J.W., Koeffler, H.P., Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines (2005) Experimental Hematology, 33, pp. 53-61Dos Santos, M.P., Schwartsmann, G., Roesler, R., Brunetto, A.L., Abujamra, A.L., Sodium butyrate enhances the cytotoxic effect of antineoplastic drugs in human lymphoblastic T-cells (2009) Leukemia Research, 33, pp. 218-221Sasaki, K., Yamagata, T., Mitani, K., Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera (2008) Cancer Science, 99, pp. 414-422Satyaraj, E., Storb, U., Mef2 proteins, required for muscle differentiation, bind an essential site in the Ig lambda enhancer (1998) Journal of Immunology, 161, pp. 4795-4802Scrideli, C.A., Assumpcao, J.G., Ganazza, M.A., Araujo, M., Toledo, S.R., Lee, M.L., Delbuono, E., Tone, L.G., A simplified minimal residual disease polymerase chain reaction method at early treatment points can stratify children with acute lymphoblastic leukemia into good and poor outcome groups (2009) Haematologica, 94, pp. 781-789Swanson, B.J., Jack, H.M., Lyons, G.E., Characterization of myocyte enhancer factor 2 (MEF2) expression in B and T cells: MEF2C is a B cell-restricted transcription factor in lymphocytes (1998) Molecular Immunology, 35, pp. 445-458Tsapis, M., Lieb, M., Manzo, F., Shankaranarayanan, P., Herbrecht, R., Lutz, P., Gronemeyer, H., HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway (2007) International Journal of Biochemistry and Cell Biology, 39, pp. 1500-1509Verdin, E., Dequiedt, F., Kasler, H.G., Class II histone deacetylases: Versatile regulators (2003) Trends in Genetics, 19, pp. 286-293Wang, L., De Zoeten, E.F., Greene, M.I., Hancock, W.W., Immunomodulatory effects of deacetylase inhibitors: Therapeutic targeting of FOXP3+ regulatory T cells (2009) Nature Reviews. Drug Discovery, 8, pp. 969-981Weichert, W., HDAC expression and clinical prognosis in human malignancies (2009) Cancer Letters, 280, pp. 168-176Weichert, W., Denkert, C., Noske, A., Darb-Esfahani, S., Dietel, M., Kalloger, S.E., Huntsman, D.G., Kobel, M., Expression of class i histone deacetylases indicates poor prognosis in endometrioid subtypes of ovarian and endometrial carcinomas (2008) Neoplasia, 10, pp. 1021-1027Weichert, W., Roske, A., Gekeler, V., Beckers, T., Ebert, M.P., Pross, M., Dietel, M., Rocken, C., Association of patterns of class i histone deacetylase expression with patient prognosis in gastric cancer: A retrospective analysis (2008) The Lancet Oncology, 9, pp. 139-148Weichert, W., Roske, A., Gekeler, V., Beckers, T., Stephan, C., Jung, K., Fritzsche, F.R., Kristiansen, G., Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy (2008) British Journal of Cancer, 98, pp. 604-610Weichert, W., Roske, A., Niesporek, S., Noske, A., Buckendahl, A.C., Dietel, M., Gekeler, V., Denkert, C., Class i histone deacetylase expression has independent prognostic impact in human colorectal cancer: Specific role of class i histone deacetylases in vitro and in vivo (2008) Clinical Cancer Research, 14, pp. 1669-1677Witt, O., Deubzer, H.E., Milde, T., Oehme, I., HDAC family: What are the cancer relevant targets? (2009) Cancer Letters, 277, pp. 8-21Yang, X., Huang, Y., Chen, J.L., Xie, J., Sun, X., Lussier, Y.A., Mechanism-anchored profiling derived from epigenetic networks predicts outcome in acute lymphoblastic leukemia (2009) BMC Bioinformatics, 10 (SUPPL. 9), p. 6Youn, H.D., Liu, J.O., Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2 (2000) Immunity, 13, pp. 85-94Youn, H.D., Sun, L., Prywes, R., Liu, J.O., Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2 (1999) Science, 286, pp. 790-793Youn, H.D., Chatila, T.A., Liu, J.O., Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis (2000) EMBO Journal, 19, pp. 4323-4331Zhou, X., Marks, P.A., Rifkind, R.A., Richon, V.M., Cloning and characterization of a histone deacetylase, HDAC9 (2001) Proceedings of the National Academy of Sciences of the United States of America, 98, pp. 10572-1057

    Crescimento relativo em Uca leptodactyla Rathbun (Crustacea Decapoda Ocypodidae) Relative growth in the fiddler crab Uca leptodactyla Rathbun (Crustacea Decapoda Ocypodidae)

    No full text
    <abstract language="eng">Relative growth of the male major chela and female abdome was studied in a population of the fiddler crab Uca leptodactyla Rathbun, 1898 from Itapoá, Santa Catarina coast, southern Brazil. Major chela length (CMQ) was measured from 191 males, and abdomen width (LAB) from 128 females. Carapace width (LC) was the reference dimension for both sexes, which ranged from 3.9 to 11.5 mm for males, and from 3.15 to 10.65 mm for females. Males grew bigger than females. Relationship between CMQ and LC showed a transition point at 8.35 mm LC in males, and between LA and LC at 7.10 mm LC in females. Growth was allometrically positive in the early ontogenesis and isometric after the puberal molting for both sexes. Regressions between LC and CMQ in males read as: logCMQ = -0,854536 + 2,19. logLC for empirical points at left of critical point and logCMQ = 0,063047 + 1,24. logLC for those at right. In females, this relation was logLAB = -0,603590 + 1,30. logLC and logLAB = -0,361464 + 1,07. logLC, respectively. These body dimensions were connected with reproductive activity of this species
    corecore