3-Hy­droxy-1,2-dimeth­oxyxanthone

The title compound (systematic name: 3-hy­droxy-1,2-dimeth­oxy-9H-xanthen-9-one), C15H12O5, was isolated from Polygala arillata. The tricyclic unit is essentially planar (r.m.s. deviation = 0.039 Å). In the crystal, the mol­ecules form stacks along the a axis. Inter­molecular O—H⋯O hydrogen bonds link the mol­ecules into chains parallel to [010]

Survival Analysis of COPD Patients in a 13-Year Nationwide Cohort Study of the Brazilian National Health System

Background: Chronic obstructive pulmonary disease (COPD) has an appreciable socioeconomical impact in low- and middle-income countries, but most epidemiological data originate from high-income countries. For this reason, it is especially important to understand survival and factors associated with survival in COPD patients in these countries. Objective: To assess survival of COPD patients in Brazil, to identify risk factors associated with overall survival, including treatment options funded by the Brazilian National Health System (SUS). Methodology: We built a retrospective cohort study of patients dispensed COPD treatment in SUS, from 2003 to 2015 using a National Database created from the record linkage of administrative databases. We further matched patients 1:1 based on sex, age and year of entry to assess the effect of the medicines on patient survival. We used the Kaplan-Meier method to estimate overall survival of patients, and Cox's model of proportional risks to assess risk factors. Result: Thirty seven thousand and nine hundred and thirty eight patients were included. Patient's survival rates at 1 and 10 years were 97.6% (CI 95% 97.4–97.8) and 83.1% (CI 95% 81.9–84.3), respectively. The multivariate analysis showed that male patients, over 65 years old and underweight had an increased risk of death. Therapeutic regimens containing a bronchodilator in a free dose along with a fixed-dose combination of corticosteroid and bronchodilator seem to be a protective factor when compared to other regimens. Conclusion: Our findings contribute to the knowledge of COPD patients' profile, survival rate and related risk factors, providing new evidence that supports the debate about pharmacological therapy and healthcare of these patients

Optimal use of visual information in adolescents and young adults with developmental coordination disorder

Recent reports offer contrasting views on whether or not the use of online visual control is impaired in individuals with developmental coordination disorder (DCD). This study explored the optimal temporal basis for processing and using visual information in adolescents and young adults with DCD. Participants were 22 adolescents and young adults (12 males and 10 females; M = 19 years, SD = 3). Half had been diagnosed with DCD as children and still performed poorly on the movement assessment battery for children (DCD group; n = 11), and half reported typical development (TD group; n = 11) and were age- and gender-matched with the DCD group. We used performance on a steering task as a measure of information processing and examined the use of advance visual information. The conditions varied the duration of advance visual information: 125, 250, 500, 750, and 1,000 ms. With increased duration of advance visual information, the TD group showed a pattern of linear improvement. For the DCD group, however, the pattern was best described by a U-curve where optimal performance occurred with about 750 ms of advance information. The results suggest that the DCD group has an underlying preference for immediate online processing of visual information. The exact timing for optimal online control may depend crucially on the task, but too much advance information is detrimental to performance

Thermalized Displaced and Squeezed Number States in Coordinate Representation

Within the framework of thermofield dynamics, the wavefunctions of the thermalized displaced number and squeezed number states are given in the coordinate representation. Furthermore, the time evolution of these wavefunctions is considered by introducing a thermal coordinate representation, and we also calculate the corresponding probability densities, average values and variances of position coordinate, which are consistent with results in the literature.Comment: 12 pages, no figures, Revtex. v3: substantially revise

Modelling sustainable intensification in Brazilian agriculture

At the United Nations Framework Conference on Climate Change COP15 (2009) Brazil presented ambitious commitments or Nationally Appropriate Mitigation Actions (NAMAs), to reduce greenhouse gases emissions (GHGs) mitigation by 2020. At COP21 (2015), the country presented new commitments and a framework to achieve further mitigation targets by 2030 as so-called Intended Nationally Determined Contributions (INDCs). Both NAMAs and INDCs focus on the land use change and agricultural sectors, but the INDCs include a commitment of zero illegal deforestation in the Amazon by 2030. This research focuses on the contribution of the livestock sector to reducing GHGs through the adoption of sustainable intensification measures. A detailed linear programming model, called Economic Analysis of Greenhouse Gases for Livestock Emissions (EAGGLE), of beef production was developed to evaluate environmental trade-offs. The modelling encompasses pasture degradation and recovery processes, animal and deforestation emissions, soil organic carbon dynamics and upstream life-cycle inventory. The model was parameterized for the Brazilian Cerrado, Amazon and Atlantic Forest biomes and further developed for farm-scale and regional-scale analysis. Different versions of the EAGGLE model was used to: (i) Evaluate the GHG mitigation potential and economic benefit of optimizing pasture management through the partitioning of initially uniform pasture area; (ii) to define abatement potential and cost-effectiveness of key mitigation measures applicable to the Brazilian Cerrado; (ii) to demonstrate the extent of cost-effective mitigation that can be delivered by the livestock sector as part of INDCs, and to show a result that underpins the national INDC target of zero deforestation; and (iv) to evaluate the consequences of reducing (or increasing) beef production on GHGs in the Cerrado. Counter-intuitively, a sensitivity analysis shows that reducing beef consumption could lead to higher GHG emissions, while increasing production could reduce total GHGs if livestock is decoupled from deforestation

Markedly Divergent Tree Assemblage Responses to Tropical Forest Loss and Fragmentation across a Strong Seasonality Gradient

We examine the effects of forest fragmentation on the structure and composition of tree assemblages within three seasonal and aseasonal forest types of southern Brazil, including evergreen, Araucaria, and deciduous forests. We sampled three southernmost Atlantic Forest landscapes, including the largest continuous forest protected areas within each forest type. Tree assemblages in each forest type were sampled within 10 plots of 0.1 ha in both continuous forests and 10 adjacent forest fragments. All trees within each plot were assigned to trait categories describing their regeneration strategy, vertical stratification, seed-dispersal mode, seed size, and wood density. We detected differences among both forest types and landscape contexts in terms of overall tree species richness, and the density and species richness of different functional groups in terms of regeneration strategy, seed dispersal mode and woody density. Overall, evergreen forest fragments exhibited the largest deviations from continuous forest plots in assemblage structure. Evergreen, Araucaria and deciduous forests diverge in the functional composition of tree floras, particularly in relation to regeneration strategy and stress tolerance. By supporting a more diversified light-demanding and stress-tolerant flora with reduced richness and abundance of shade-tolerant, old-growth species, both deciduous and Araucaria forest tree assemblages are more intrinsically resilient to contemporary human-disturbances, including fragmentation-induced edge effects, in terms of species erosion and functional shifts. We suggest that these intrinsic differences in the direction and magnitude of responses to changes in landscape structure between forest types should guide a wide range of conservation strategies in restoring fragmented tropical forest landscapes worldwide