IDENTIFICAÇÃO DE GENÓTIPOS DE FEIJOEIRO COMUM TOLERANTES AO ALUMÍNIO

Este trabalho teve como objetivo identificar genótipos de feijão comum tolerantes ao alumínio, em solução nutritiva. O experimento foi conduzido em condições de casa de vegetação, na Universidade Federal do Tocantins – Campus Universitário de Gurupi – TO, em blocos inteiramente casualizados, com seis repetições e tratamentos dispostos em esquema fatorial constituído por 15 genótipos e quatro tratamentos: 0, 3 e 6 mg L-1 de alumínio em pH 4,0 ± 0,2 e 0 mg L-1 de alumínio em pH 6,5 ± 0,2. Foram avaliadas as seguintes características: comprimento da parte aérea, comprimento radicular, massa seca da parte aérea e massa seca radicular. Concluiu-se que existe variabilidade genética entre os genótipos de feijão comum quanto à tolerância ao alumínio. Os cultivares IPR Chopim e VC3 foram considerados tolerantes ao alumínio, apresentando bom desenvolvimento radicular. Com isso, a utilização desses genótipos em programas de melhoramento genético pode ser uma alternativa para a agricultura familiar, por possuírem características agronômicas desejáveis relacionadas à tolerância por alumínio

CARGA IMEDIATA EM IMPLANTES DENTÁRIOS: AVALIAÇÃO DOS RESULTADOS CLÍNICOS E BIOLÓGICOS A CURTO E A LONGO PRAZO.

The present study aims to review the clinical and biological results associated with immediate loading of dental implants, addressing current evidence available in the scientific literature. An extensive literature review was carried out to identify relevant studies regarding the proposal of the present study. Electronic databases, such as PubMed, Scopus, SciELO and Google Scholar, were consulted to obtain published articles. Immediate loading, defined as the application of functional loading immediately after implant installation, represents a significant advance in clinical dental practice. However, more research is needed to validate these findings and to guide evidence-based clinical decisions and promote better results for patients undergoing this treatment modality. Ultimately, this study contributes to the advancement of scientific knowledge in the area of ​​dental implants, providing a basis for the development of more effective and personalized clinical protocols. Despite the evident benefits in terms of reducing treatment time and improving patients' quality of life, challenges such as peri-implant complications and marginal bone loss are discussed, emphasizing the need for careful case selection and rigorous monitoring to ensure satisfactory long-term results. This article highlights the importance of individualized, evidence-based assessment when implementing immediate loading of dental implants.O presente estudo possui como objetivo revisar os resultados clínicos e biológicos associados à carga imediata em implantes dentários, abordando evidências atuais disponíveis na literatura científica.  Realizou-se uma revisão da literatura para identificar estudos relevantes acerca da proposta do presente estudo. Bases de dados eletrônicas, como PubMed, Scopus, SciELO e Google Scholar, foram consultadas para obter artigos publicados. A carga imediata, definida como a aplicação de carga funcional imediatamente após a instalação do implante, representa um avanço significativo na prática clínica odontológica. No entanto, é necessário realizar mais pesquisas para validar esses achados e para orientar decisões clínicas baseadas em evidências e promover melhores resultados para os pacientes submetidos a essa modalidade de tratamento. Em última análise, este estudo contribui para o avanço do conhecimento científico na área de implantes dentários, fornecendo uma base para o desenvolvimento de protocolos clínicos mais eficazes e personalizados. Apesar dos benefícios evidentes em termos de redução do tempo de tratamento e melhoria da qualidade de vida dos pacientes, são discutidos os desafios como complicações peri-implantares e perda óssea marginal, enfatizando a necessidade de uma seleção criteriosa dos casos e um acompanhamento rigoroso para garantir resultados satisfatórios a longo prazo. Este artigo destaca a importância da avaliação individualizada e baseada em evidências na implementação da carga imediata em implantes dentários

IDENTIFICAÇÃO DE GENÓTIPOS DE FEIJOEIRO COMUM TOLERANTES AO ALUMÍNIO

Este trabalho teve como objetivo identificar genótipos de feijão comum tolerantes ao alumínio, em solução nutritiva. O experimento foi conduzido em condições de casa de vegetação, na Universidade Federal do Tocantins – Campus Universitário de Gurupi – TO, em blocos inteiramente casualizados, com seis repetições e tratamentos dispostos em esquema fatorial constituído por 15 genótipos e quatro tratamentos: 0, 3 e 6 mg L-1 de alumínio em pH 4,0 ± 0,2 e 0 mg L-1 de alumínio em pH 6,5 ± 0,2. Foram avaliadas as seguintes características: comprimento da parte aérea, comprimento radicular, massa seca da parte aérea e massa seca radicular. Concluiu-se que existe variabilidade genética entre os genótipos de feijão comum quanto à tolerância ao alumínio. Os cultivares IPR Chopim e VC3 foram considerados tolerantes ao alumínio, apresentando bom desenvolvimento radicular. Com isso, a utilização desses genótipos em programas de melhoramento genético pode ser uma alternativa para a agricultura familiar, por possuírem características agronômicas desejáveis relacionadas à tolerância por alumínio

G-CSF does not improve systolic function in a rat model of acute myocardial infarction

OBJECTIVEGranulocyte colony-stimulating factor (G-CSF) has been reported to improve cardiac performance by increasing the number of bone marrow stem cell in the peripheral circulation. The aim of this study was to investigate the impact of G-CSF administration on cardiac function in a rat model of acute myocardial infarction.METHODSRecombinant human G-CSF (Filgrastim, 100 microg/kg, sc) twice a day during seven consecutive days (G-CSF group, n=13) or vehicle (control group, n=10) was administrated three hours after left anterior coronary artery ligation. Cardiac performance was evaluated 19-21 days after myocardial infarction by electro- and echocardiography, hemodynamic and treadmill exercise test.RESULTSBoth infarcted groups exhibit impaired cardiac function compared to sham-operated rats. Moreover, all cardiac functional parameters were not statistically different between G-CSF and infarcted group at resting conditions as well as after treadmill exercise stress test. There was no sign of cardiac regeneration and infarct size was not different on histological analysis between groups.CONCLUSIONSThese data clearly shows that G-CSF treatment was unable to prevent cardiac remodeling or to improve cardiovascular function in a rat model of acute myocardial infarction, by permanent LAD ligation, despite bone marrow stem cell mobilization

Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

Background Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)

Global economic burden of unmet surgical need for appendicitis

Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially

Global economic burden of unmet surgical need for appendicitis

Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially