High-Q nested resonator in an actively stabilized optomechanical cavity

Experiments involving micro- and nanomechanical resonators need to be carefully designed to reduce mechanical environmental noise. A small scale on-chip approach is to add an additional resonator to the system as a mechanical low-pass filter. Unfortunately, the inherent low frequency of the low-pass filter causes the system to be easily excited mechanically. Fixating the additional resonator ensures that the resonator itself can not be excited by the environment. This, however, negates the purpose of the low-pass filter. We solve this apparent paradox by applying active feedback to the resonator, thereby minimizing the motion with respect the front mirror of an optomechanical cavity. Not only does this method actively stabilize the cavity length, but it also retains the on-chip vibration isolation.Comment: Minor adjustments mad

Information systems for development planning

In this paper the changing approaches to development planning are described, from the economic-growth oriented strategies of the 1950s and the 1960s to the contemporary emphasis on alleviating poverty and meeting basic needs. The process of development planning includes several phases; the identification of aims, analysis, plan formulation and detailed design, Implementation, controls, updating, and feedback and adjustment. This process has become much more sophisticated in recent years, but in general, the comprehensiveness and refinement of a development plan depends on the type and scope of the data available. At the same time, the very process of planning may reveal deficiencies In data and thus act as an incentive to improved information gathering. Three information systems are needed for development planning: a resources information system, whose importance has been recognised for some time but which has frequently consisted of a series of isolated and uncoordinated inventories and studies; a scientific and technological information system' and a management information system, whose Importance has frequently been neglected. Information in these areas must be collected, communicated to government policy makers and administrators to meet their immediate needs, and stored in a convenient and coordinated form so that it will be accessible in the future. More global surveys and inventories will be needed during the eiarly stages of development planning, and detailed project and programme surveys will be needed during the design and implementation stages

Synthesis and biological evaluation of immunoconjugates of adriamycin and a human IgM linked by poly[N5-(2-hydroxyethyl)-l-glutamine

The synthesis and purification of radiolabelled immunoconjugates, composed of a human IgM monoclonal antibody (IgM 16.88) directed against an intracellular tumour-associated antigen, the drug carrier poly[N5-(2-hydroxyethyl)--glutamine] (PHEG) and the cytostatic drug adriamycin (ADR) are described. The immunoconjugates were constructed to allow selective release of ADR in the putatively acidic environment of the tumour through a novel acid-labile maleamic acid linker. The conjugate of PHEG and the acid-labile ADR derivative effectively released ADR in cytotoxic amounts at a pH of 6.0 as judged from incubation in buffer and from inhibition of the growth of HT-29 colon tumour cells in vitro. Immunoconjugates were prepared by coupling of PHEG-ADR having a hydrolytically stable amide bond with 131I-labelled antibody through thioether bond formation involving a single thiol group at the C-terminus of the polymer chain and maleimido groups introduced onto th

Журнал кримських караїмів “Бизым йол” (“Наш шлях”) у світлі традицій караїмської преси і національної політики Кримської АРСР

В статье содержится описание караимских периодических изданий начала ХХ века, их целей и задачи, объема, основных отделов, исследуется отражение в караимской периодике процессов национального культурного ренессанса, изучается связь этнических изданий караимов с общественно-политической жизнью караимской общины.Стаття містить опис караїмських видань початку ХХ століття, з'ясовує їхні цілі і завдан-ня, обсяг, основні розділи; досліджує відбиття у караїмській періодиці процесів національного культурного ренесансу; вивчає зв'язок етнічних видань караїмів із суспільно-політичним життям караїмської громади.The article researches the Karaite mass media of the beginning of the XX century: its matters and tasks, volume, main sections, the reflection of the cultural renaissance in it and its connection with life of the Karaite community