Screening out irrelevant cell-based models of disease

The common and persistent failures to translate promising preclinical drug candidates into clinical success highlight the limited effectiveness of disease models currently used in drug discovery. An apparent reluctance to explore and adopt alternative cell-and tissue-based model systems, coupled with a detachment from clinical practice during assay validation, contributes to ineffective translational research. To help address these issues and stimulate debate, here we propose a set of principles to facilitate the definition and development of disease-relevant assays, and we discuss new opportunities for exploiting the latest advances in cell-based assay technologies in drug discovery, including induced pluripotent stem cells, three-dimensional (3D) co-culture and organ-on-a-chip systems, complemented by advances in single-cell imaging and gene editing technologies. Funding to support precompetitive, multidisciplinary collaborations to develop novel preclinical models and cell-based screening technologies could have a key role in improving their clinical relevance, and ultimately increase clinical success rates

Descubrimiento de proximidad, autenticación y establecimiento de enlace entre dispositivos móviles de comunicación en LTE 3GPP

Un método para el descubrimiento de proximidad entre un dispositivo origen (1) y uno o más dispositivos objetivo (2) en donde el dispositivo origen (1) y el uno o más dispositivos objetivo (2) están configurados para conectarse en comunicación a una red, comprendiendo dicho método los pasos de: recibir (101) en el dispositivo origen (1) desde un servidor (3) en la red unos primeros datos (11) que comprenden un identificador (12), en donde el identificador (12) es un identificador temporal de difusión que identifica de forma unívoca al dispositivo origen (1); recibir (102) en el dispositivo objetivo (2) desde el servidor (3) unos segundos datos (20) que comprenden una primera representación (21) del identificador (12) del dispositivo origen (1) con el fin de permitir que el dispositivo objetivo (2) asocie el identificador (12) al dispositivo origen (1); difundir (103) por parte del dispositivo origen (1) una señal (30) que comprende una segunda representación del identificador (31) del dispositivo origen (1); recibir (104) en el dispositivo objetivo (2) la señal (30); y comparar (105) en el dispositivo objetivo la primera representación (21) del identificador (12) con la segunda representación (31) del identificador (12) para obtener un resultado de la comparación con el fin de establecer un descubrimiento de proximidad exitoso

Descubrimiento de proximidad asistido por la red, autenticación y establecimiento de enlace entre dispositivos móviles de comunicación en LTE 3GPP

La invención permite que un dispositivo descubra uno o más otros dispositivos dentro del rango para un modo de comunicación de dispositivo a dispositivo. Este descubrimiento de proximidad puede activar un dispositivo objetivo, p. Para comenzar a escuchar señales desde un dispositivo fuente o realizar cualquier otra acción basada en el descubrimiento de proximidad, como p. Cargando en una puerta de peaje. Un dispositivo fuente que desea descubrir transmite un mensaje que incluye un identificador o una representación del identificador. Este identificador puede ser un identificador del dispositivo de destino que se contactará o del dispositivo de origen o una derivación del mismo o una asociación de seguridad común utilizada por un conjunto de pares. El dispositivo objetivo compara el identificador de transmisión con un identificador conocido para establecer el descubrimiento de proximidad. (Traducción automática con Google Translate, sin valor legal

Network-assisted proximity discovery, authentication and link establishment between communication mobile devices in 3GPP LTE

The invention enables a device to discover one or more other devices within range for a device-to-device mode of communication. This proximity discovery may trigger a target device, e.g. to start listening to signals from a source device or perform any other action based on the proximity discovery like e.g. charging at a toll gate. A source device that wants to be discovered broadcasts a message including an identifier or a representation of the identifier. This identifier may be an identifier of the target device to be contacted or of the source device or a derivation thereof or a common security association used by a set of peers. The target device compares the broadcast identifier with a known identifier to establish proximity discovery

Proximity Discovery, Authentication and Link Establishment Between Mobile Devices in 3GPP LTE

The invention enables a device to discover one or more other devices within range for a device-to-device mode of communication. This proximity discovery may trigger a target device, e.g. to start listening to signals from a source device or perform any other action based on the proximity discovery like e.g. charging at a toll gate. A source device that wants to be discovered broadcasts a message including an identifier or a representation of the identifier. This identifier may be an identifier of the target device to be contacted or of the source device or a derivation thereof or a common security association used by a set of peers. The target device compares the broadcast identifier with a known identifier to establish proximity discovery

Proximity discovery, authentication and link establishment between communication mobile devices in 3GPP LTE

The present invention allows a device to discover one or more devices that are within range for a diverse communication mode. This proximity discovery may trigger the target device to begin listening to the signal from, for example, the source device or to perform any other action based on proximity discovery such as, for example, a request at the toll gate. The source device wishing to be discovered broadcasts a message containing an identifier or a representation of the identifier. This identifier may be an identifier of the target device or source device to which it is intended to be connected, its derived type, or a common security association used by the set of peers. The target device compares the broadcast identifier with a known identifier to establish proximity discovery

Proximity discovery, authentication and link establishment between communication mobile devices in 3GPP LTE

The invention enables a device to discover one or more other devices within range for a device-to-device mode of communication. This proximity discovery may trigger a target device, e.g. to start listening to signals from a source device or perform any other action based on the proximity discovery like e.g. charging at a toll gate. A source device that wants to be discovered broadcasts a message including an identifier or a representation of the identifier. This identifier may be an identifier of the target device to be contacted or of the source device or a derivation thereof or a common security association used by a set of peers. The target device compares the broadcast identifier with a known identifier to establish proximity discovery

Dutch translation of the Kujala Anterior Knee Pain Scale and validation in patients after knee arthroplasty

To translate and validate the Kujala Anterior Knee Pain Scale (AKPS) in patients who have undergone total knee arthroplasty (TKA) or unicompartmental knee arthroplasty (UKA) and evaluate the internal consistency, construct validity and ceiling or floor effect. After standard forward and backward translation was performed, 302 patients who have received a TKA or UKA filled out the AKPS together with Hospital for Special Surgery (HSS) patella score, visual analogue score (VAS) for pain, the Oxford 12-item questionnaire and the SF-36 at follow-up. The internal consistency was tested using Cronbach's α coefficient. The construct validity was assessed using Spearman's rank correlation (R) to test for correlations between the AKPS and VAS HSS, HSS patella score, VAS month, Oxford 12-item questionnaire and SF-36 subscales. Ceiling or floor effects are given in percentage of patients giving a maximum or minimum score. The internal reliability of the AKPS is acceptable with a Cronbach's α of 0.81 in patients after TKA or UKA. A high correlation was found between the AKPS and the Oxford 12-item questionnaire (R = 0.81). Moderate correlations were found with the VAS month (R = 0.63), HSS patella score (R = 0.51) and SF-36 subscales physical functioning (R = 0.59), role-physical (R = 0.59), bodily pain (R = 0.57). Other correlations were poor, therefore indicating a good convergent and divergent validity. Ceiling effects were observed for the HSS patella score (31 %), VAS HSS (51 %), VAS pain (19 %), SF36-RP (46 %), SF36-RE (80 %) and SF36-BP (24 %). No ceiling or floor effect was found for the AKPS, Oxford 12-item and the other SF36 domains. The AKPS appears to be reliable and valid in patients after knee arthroplasty, with no ceiling and floor effects, and can be used to assess anterior knee pain in patient who underwent joint replacement surger