Multifunctional device for bicycles

This paper aims at designing a "Multifunctional device composed of load support and anti-theft lock for standard bicycles". A previous study has been developed in order to justify and validate the final design of the unmet needs of people in their daily lives, with an emphasis on satisfying those that imply specific savings, whether economic, energy or time. As a result, the use of bicycles as a means of transport in Spain is promoted taking as a frame of reference countries such as the Netherlands or France. This means economic and energy savings (by replacing the car) and an improvement in people's health and quality of life. Following the steps of the design methodology, once the need was detected, an information search was carried out in order to identify and prioritize the design specifications that meet the demands of potential customers. For this reason, various sources were used, The boost to use bicycles has allowed to establish a set of measurements and specifications in the design of the device with a double functionality, the transport of merchandise and an anti-theft system. In addition to meeting the needs of the client, the design must comply with a set of reference regulations both, at the level of security devices and the transport of merchandise at retail. The result of the work has given rise to patent application with prior examination at a national level, in a first phase, and subsequently, at an international level.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Measurement device design: Rain gauge

The need to size large hydraulic infrastructures, exploit extensive agricultural areas or simply arrange water assets for human consumption makes the evaluation of the available water resources essential. Water is a scarce resource that is poorly distributed both, spatially and temporally. Therefore, a set of hydrological networks that allow the evaluation of water quantity and quality is required. In order to achieve this, the first step is to retrieve reliable data on rainfall. To carry out a correct evaluation of water resources, both in the small and large scale, disposing hydrological networks that involve a certain number of measuring devices becomes critical. Despite the great amount of studies that have been developed on measuring devices such as rain gauges, there are still many errors that remain in the measurements and that have not been ruled out yet, thus affecting the accuracy of the measurements. In this sense, the design of a device that provides an accurate measurement of rainfall and also results affordable, could be the key to a product with great acceptance in the market. The aim of this work is to present the design of a measurement device that provides accurate data and can be used in multiple ways: as an ordinary rain gauge, as a rain gauge recorder, or even allowing to carry on both functions simultaneously. The methodology followed for its implementation has consisted in analyzing the techniques and procedures to be trailed at quantifying rainfall, conducting a market study and analyzing specifications to be in accordance to WMO (World Meteorological Organization) [2] [3] to then go through a conceptual design and finally complete the detailed design where materials are valued and simulation tests are performed in order to meet certain accuracy and economical requirements.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

3D Digital techniques applied to new design products based on cultural heritage elements

The aim of this paper is to present the 3D digitalization and posterior treatment of complex heritage elements existing in the Alhambra Palace, so that they can be used as the starting point for the development of new products. Not only are the direct results of 3D digitalization exploitable and essential for the documentation, recording and research of heritage elements, but also these 3D files compiling the original elements are to be used as the blueprints for the future development of new products and designs, such as constructive elements regarding their application at interior design and architecture projects. The enrichment provided in new products is undeniable as they will depart from the same provenance as the heritage element, which allows the product to increase its market value, and the opening of new Market niches. It is very important to highlight that any new product creation process will be grounded in full respect and protection of cultural heritage. For this reason, under no circumstances will the original elements be completely reproduced, not even partial developments of them since this action could undergo the risk of a non-responsible reproduction of the heritage elements.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Intracellular vesicle trafficking plays an essential role in mitochondrial quality control

The Drosophila gene products Bet1, Slh, and CG10144, predicted to function in intracellular vesicle trafficking, were previously found to be essential for mitochondrial nucleoid maintenance. Here we show that Slh and Bet1 cooperate to maintain mitochondrial functions. In their absence, mitochondrial content, membrane potential, and respiration became abnormal, accompanied by mitochondrial proteotoxic stress, but without direct effects on mtDNA. Immunocytochemistry showed that both Slh and Bet1 are localized at the Golgi, together with a proportion of Rab5-positive vesicles. Some Bet1, as well as a tiny amount of Slh, cofractionated with highly purified mitochondria, while live-cell imaging showed coincidence of fluorescently tagged Bet1 with most Lysotracker-positive and a small proportion of Mitotracker-positive structures. This three-way association was disrupted in cells knocked down for Slh, although colocalized lysosomal and mitochondrial signals were still seen. Neither Slh nor Bet1 was required for global mitophagy or endocytosis, but prolonged Slh knockdown resulted in G2 growth arrest, with increased cell diameter. These effects were shared with knockdown of betaCOP but not of CG1044, Snap24, or Syntaxin6. Our findings implicate vesicle sorting at the cis-Golgi in mitochondrial quality control.Peer reviewe

Diseño de mobiliario urbano para rehabilitación de espacios

La propuesta de trabajo parte de una de las líneas estratégicas del Vicerrectorado de Smart Campus (VSC) de la Universidad de Málaga (UMA), concretamente dentro de la línea “Naturaleza y medioambiente” con el proyecto denominado “Islas y Sendas Verdes” (ISV). El principal objetivo del proyecto es, a partir de un equipo multidisciplinar, desarrollar un espacio de ocio, esparcimiento, descanso, estudio al aire libre, sensorizado y sostenible, que cumpla los requisitos de los usuarios, haciendo que es-tas zonas tengan mayor vida social. La propuesta del presente trabajo es la creación de un diseño de mobiliario urbano que será ubicado en la zona exterior de la ESTI de Informática y la ETSI de Telecomunicación de la UMA. La metodología seguirá las fases del diseño y desarrollo de productos, comenzando con el estudio de mercado y la competencia, establecimiento de los requisitos del cliente y del producto, desarrollo y discusión de la idea y, por último, la propuesta definitiva a través del diseño técnico o de detalle donde el producto queda complemente definido en cuanto a forma, funcionalidad, materiales y resistencia mecánica. El resultado del proyecto muestra el desarrollado de un prototipo virtual que cumple con las especificaciones establecidas, obteniendo el primer premio del I Concurso de Islas y Sendas Verdes.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

GEPM : gestió d'equipaments públics municipals

Aquest projecte presenta una solució integral e integrada per a la gestió d'equipaments públics municipals. És integral ja que contempla tots els aspectes de la gestió, mitjançant diferents canals en funció del perfil d'usuari que l'utilitza ; és integrada ja que proporciona una solució integrada amb l'ERP corporatiu existent actualment a l'Ajuntament per al qual s'ha desenvolupat. El projecte presenta els següents canals de gestió: Aplicació Windows desenvolupada en .NET, Extranet de gestió amb gestió de continguts, Aplicació web per dispositius mòbils i Web informativa de recollida selectiva i neteja viària. El projecte també disposa de connexió al gestor documental Documentum de EMC2.Este proyecto presenta una solución integral e integrada para la gestión de equipamientos públicos municipales. Integral ya que contempla todos los aspectos de la gestión mediante diferentes canales en función del perfil del usuario que la utiliza; e integrada ya que proporciona una solución integrada con el ERP corporativo existente actualmente en el Ayuntamiento para el que se ha desarrollado. El proyecto presenta los siguientes canales de gestión: Aplicación Windows desarrollada en .NET, Extranet de gestión con gestión de contenidos, Aplicación web para dispositivos móviles y Web informativa de recogida selectiva y limpieza viaria. El proyecto también dispone de conexión al gestor documental Documentum de EMC2.This project presents a integral and integrated solution for the management of public municipal equipments. Integral since contemplates all the aspects of the management by means of different channels depending on the profile of the user who uses it and integrated because provides a solution integrated with the corporate existing ERP in the Town hall for the one that's developed. The project presents the following management channels: Windows Application developed in .NET, Extranet of management with contents management, Web application for mobile devices and Informative Web of selective withdrawal and cleanliness streets. The project also provides connection to the documental manager Documentum of EMC2.Nota: Aquest document conté originàriament altre material i/o programari només consultable a la Biblioteca de Ciència i Tecnologia

RNase H1 promotes replication fork progression through oppositely transcribed regions of Drosophila mitochondrial DNA

Mitochondrial DNA (mtDNA) replication uses a simple core machinery similar to those of bacterial viruses and plasmids, but its components are challenging to unravel. Here, we found that, as in mammals, the single Drosophila gene for RNase H1 (rnh1) has alternative translational start sites, resulting in two polypeptides, targeted to either mitochondria or the nucleus. RNAi-mediated rnh1 knockdown did not influence growth or viability of S2 cells, but compromised mtDNA integrity and copy number. rnh1 knockdown in intact flies also produced a phenotype of impaired mitochondrial function, characterized by respiratory chain deficiency, locomotor dysfunction, and decreased lifespan. Its overexpression in S2 cells resulted in cell lethality after 5-9 days, attributable to the nuclearly localized isoform. rnh1 knockdown and overexpression produced opposite effects on mtDNA replication intermediates. The most pronounced effects were seen in genome regions beyond the major replication pauses where the replication fork needs to progress through a gene cluster that is transcribed in the opposite direction. RNase H1 deficiency led to an accumulation of replication intermediates in these zones, abundant mtDNA molecules joined by four-way junctions, and species consistent with fork regression from the origin. These findings indicate replication stalling due to the presence of unprocessed RNA/DNA heteroduplexes, potentially leading to the degradation of collapsed forks or to replication restart by a mechanism involving strand invasion. Both mitochondrial RNA and DNA syntheses were affected by rnh1 knockdown, suggesting that RNase H1 also plays a role in integrating or coregulating these processes in Drosophila mitochondria.Peer reviewe

Hacia la transversalidad entre asignaturas como mejora de la práctica docente en el ámbito de la Ingeniería Industrial

El presente artículo describe el proceso de enseñanza/aprendizaje que se está realizando, como innovación educativa, en un periodo de tiempo que abarca dos cursos académicos consecutivos. Se ha definido como herramienta de trabajo el diseño de un aprendizaje basado en proyectos, con un carácter transversal, involucrando, para ello, a los estudiantes que proceden de estudios de Grado de Ingeniería en la Energía y del Grado en Ingeniería de Tecnologías Industriales de la Universidad de Málaga (España). Se trata de un proyecto que busca la transversalidad y permitirá exportar el esquema de trabajo a otras asignaturas de Ingeniería, en las que el trabajo de campo y de gabinete requiere de colaboración entre alumnos/as, no necesariamente de la misma titulación y manifestará las fortalezas y debilidades del proceso seguido. Además, se han planteado situaciones reales en las que datos tomados por distintos/as alumnos/as sirven de soporte para el resto, equiparando el trabajo realizado en las distintas asignaturas como una cadena de producción de ingenieríaUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Este trabajo ha sido parcialmente financiado por el Proyecto de Innovación Educativa PIE13/076 del Vicerrectorado de Ordenación Académica y Profesorado de la Universidad de Málag

Procedimiento para la incorporación de resultados de aprendizaje en las guías docentes, orientado a la acreditación de títulos de Grado en Ingeniería

La última fase del proceso de evaluación externa de los títulos oficiales es una comprobación del ajuste existente entre el título implantado y el diseño propuesto inicialmente, contemplando las acciones realizadas sobre las posibles desviaciones y sus causas. Una de las dimensiones más relevantes en esta comprobación son los resultados de aprendizaje. En el presente trabajo se presenta un procedimiento desarrollado, apoyado en una base de da-tos relacional, con el fin de trasladar al profesorado la importancia de estos resultados y fomentar la incorporación de los mismos en las guías docentes de las asignaturas. Los resultados obtenidos justifican el procedimiento desarrollado.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech