Investigação sintomatológica e complicações por Covid-19 de pacientes pós-internamento entre os anos de 2020 e 2021 em um estado brasileiro

O objetivo do estudo foi descrever vestígios sintomatológicos relacionados a sequelas e complicações de Covid-19 em pacientes pós-internamento entre os anos de 2020 e 2021. Trata-se de um estudo descritivo analítico do tipo transversal com abordagem quantitativa realizado no período de maio a agosto de 2021. A amostra foi constituída de 470 pacientes, sendo 275 referentes a primeira onda corrida no ano de 2020 e 195 na segunda no ano de 2021. O estudo foi desenvolvido por meio do método de telepesquisa via ligações telefônicas. O preenchimento dos dados ocorreu via Google Forms, contando de questionário estruturado desenvolvido para a pesquisa. Os dados foram tabulados em planilha Excel® para geração de gráfico e tabelas e analisados conforme estatística descritiva. Na investigação de sintomas físicos desse estudo, nota-se que fadiga/cansaço mostrou maior destaque, principalmente na comparação entre a 1ª onda com 27,30% e 2ª em torno de 40%, seguido de alopecia 1ª com 20,70% e 2ª 40,5%, e por último, falta de ar 1ª com percentual de 18,9% e 2ª equivalente a 11,3%. A pesquisa revelou um acometimento da amostra em sintomas de caráter físico e psicológico logo após o internamento por Coronavírus. Dessa forma, uma investigação mais detalhada e minuciosa com a mesma população permitirá o aprofundamento de causas e fatores que podem estar relacionados com o surgimento dessas alterações

Increased expression of protease-activated receptor 1 (PAR-1) in human leukemias

Protease-activated receptor 1 (PAR-1) is a G-protein-coupled receptor that is overexpressed in solid tumors, being associated with several pro-tumoral responses including primary growth, invasion, metastasis and angiogenesis. Expression of PAR-1 in human leukemic cell lines is reported but the status of its expression in human leukemic patients is currently unknown. In this study we evaluated the expression pattern of PAR-1 in patients with the four main types of leukemia - chronic lymphocytic leukemia subtype B (B-CLL), acute lymphoblastic leukemia subtype B (B-ALL), acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). Flow cytometry analyses show that lymphocytes from B-CLL patients express this receptor at similar levels to healthy individuals. On the other hand, it was observed a significant increase in PAR-1 expression in B-ALL lymphocytes as compared to B-CLL and healthy donors. Flow cytometric and real-time PCR demonstrated a significant increase in PAR-1 expression in granulocytes from CML patients in blast phase (CML-BP) but not in chronic phase (CML-CP) as compared to healthy donors. Finally, a significant increase in PAR-1 expression has been also observed in blasts from AML (subtypes M4 and M5) patients, as compared to monocytes or granulocytes from healthy donors. We conclude that PAR-1 might play an important biological role in aggressive leukemias and might offer additional strategies for the development of new therapies. (C) 2010 Elsevier Inc. All rights reserved.Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Fundacao de Amparo Pesquisa do Estado do Rio de Janeiro Carlos Chagas Filho (FAPERJ)Fundacao do Cance

NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics

Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data