Biometrics of the primary dentition in a Nigerian sample

Objective: The purpose of this study was to determine normative values of crown dimensions, arch dimensions, and amount of interdental space in the primary dentition of Nigerian children. Method: Dental casts from alginate impressions obtained from 125 randomly selected nursery school children (65 boys, 60 girls) aged 3 to 5 years, were measured with electronic caliper. Independent tests were used to analyze sample differences between sexes. Result: There were significant gender differences in arch width, depth and length dimensions, with the exception of the left mandibular anterior length. The boys showed significantly larger mesiodistal crown dimensions, except in the maxillary and mandibular primary lateral incisors. Gender differences in buccolingual crown diameters were statistically significant for maxillary second primary molars. There was no significant gender difference in amount of interdental spaces. Conclusion: It can be concluded that males had larger tooth/arch dimensions than females in the primary dentition stage

A cephalometric assessment of the nasolabial angle of an adult Nigerian population

Objective: One of the most important components of orthodontic diagnosis and treatment planning is an evaluation of the patient\u27s soft tissue profile. An assessment of the nasolabial angle is a vital component of this evaluation. The purpose of this study was to establish norms for the nasolabial angle of an adult Nigerian population; compare the male and female values and to compare the values obtained for Nigerians with those reported for other populations. Method: Lateral cephalometric radiographs of one hundred students (44 males and 56 females) of the College of Medicine, University of Lagos, aged 18-25years were taken. Selected subjects were of Nigerian ancestry with normal occlusion. The radiographs were manual ly t raced and the nasolabial angle of each subject measured. Result: A mean value of 84.35° +13.71° was computed for the entire sample. No statistically significant difference was observed between the male and female values (p>0.05), although 0 0 the males recorded a lower nasolabial angle (83.70 ) than the females (85.28 ).The nasolabial angle recorded in this study was similar to that reported for South African blacks, but much lower than that reported for Caucasian populations.Conclusion: The mean nasolabial angle of 84.35 + 13.71 was observed in the Nigerian population studied. Sexual differences were not observed; however, the values observed in this study differ from that reported for Caucasians and other racial groups

Restorative and orthodontic interdisciplinary management of an adult patient using modified Hawley appliance: a case report

This report presents a case of an adult female patient who had undergone orthodontic treatment to correct her malocclusion was referred to the Restorative Dentistry Clinic at the time when her brackets were due for debonding. The patient had presented with spacing of the anterior segments of both upper and lower arches with the upper canines in crossbite. At the end of the orthodontic correction of the occlusion the patient was referred to the restorative dentist for replacement of missing molars in the upper and lower arches. Fixed bridge prosthesis, implant-retained crowns or removable dentures were the treatment options for tooth replacement. Due to financial challenges the first two options were unavailable to the patient. The need to wear retainers made it impractical for the patient to be provided the third option of removable dentures. A modified design of Hawley retainers was then made for the patient that had pink acrylic bases and acrylic stock teeth to replace missing teeth. Thus, the functions of retainer and removable denture were combined in one appliance. The modified Hawley appliance designed for the patient in this study is a typical example of interdisciplinary management by the restorative dentist and the orthodontist to give appropriate care to the adult orthodontic patient

Knowledge and awareness of orthodontics among Nigerian school children in selected private and public schools in Lagos

Objective: This study sought to assess the knowledge and awareness of Nigerian adolescents concerning orthodontics, to determine possible factors influencing their knowledge of orthodontics as well as to find out if socioeconomic status has any effect on their knowledge and awareness. Method: This cross-sectional descriptive questionnaire based study was conducted in two secondary schools (one private and one public) in Lagos State. Result: A total of 408 students, participated in the study of which only 98 (24.0%) had ever heard the term ‘orthodontics’, and of this number only 16 could correctly explain the meaning of the term orthodontics. Majority of the respondents with correct responses attended a private school. Significantly more of the private school students correctly identified that orthodontists are involved in rearranging the teeth (p=0.006) and not involved in cleaning the teeth (p=0.008). There was a significant difference in the knowledge of the students from the public and private school concerning the impact of malocclusion on speech (p=0.002) and appearance (p=0.000). The overall orthodontic knowledge is deficient. However knowledge was better among the children from the private school compared to those from the public school. The results obtained from this study, clearly show that there is need to provide oral health education especially to improve the orthodontic knowledge of these adolescents especially about malocclusion and its consequences. It is expected that this would improve their knowledge and consequently increase the demand for and the uptake of the available orthodontic services

Inhibition of the mitochondrial calcium uniporter (MCU) rescues dopaminergic neurons in pink1-/- zebrafish

Mutations in PTEN-induced putative kinase 1 (PINK1) are a cause of early onset Parkinson's disease (PD). Loss of PINK1 function causes dysregulation of mitochondrial calcium homeostasis, resulting in mitochondrial dysfunction and neuronal cell death. We report that both genetic and pharmacological inactivation of the mitochondrial calcium uniporter (MCU), located in the inner mitochondrial membrane, prevents dopaminergic neuronal cell loss in pink1Y431* mutant zebrafish (Danio rerio) via rescue of mitochondrial respiratory chain function. In contrast, genetic inactivation of the voltage dependent anion channel 1 (VDAC1), located in the outer mitochondrial membrane, did not rescue dopaminergic neurons in PINK1 deficient Danio rerio. Subsequent gene expression studies revealed specific upregulation of the mcu regulator micu1 in pink1Y431* mutant zebrafish larvae and inactivation of micu1 also results in rescue of dopaminergic neurons. The functional consequences of PINK1 deficiency and modified MCU activity were confirmed using a dynamic in silico model of Ca2+ triggered mitochondrial activity. Our data suggest modulation of MCU-mediated mitochondrial calcium homeostasis as a possible neuroprotective strategy in PINK1 mutant PD

Teste de inibição da enzima acetilcolinesterase de compostos organofosforados com potencial ação fungicida na cultura de mamão (Carica papaya L.).

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Outcomes associated with antibiotic regimens for treatment of Mycobacterium abscessus in cystic fibrosis patients

Background Mycobacterium abscessus infection is associated with declining lung function in cystic fibrosis (CF), but there is little evidence on clinical efficacy to guide treatment. Methods Retrospective review of 37 CF patients treated for M. abscessus respiratory infection at a single center from 2006 to 2014. Outcomes included change in FEV1 at 30, 60, 90, 180, and 365 days after treatment and clearance of M. abscessus from sputum cultures. Results Lung function was significantly improved after 30 and 60 days of treatment, but not at later time points. Gains were inversely related to starting lung function. Antibiotic choices did not influence outcomes except for greater clearance with clarithromycin. Conclusions Treatment of M. abscessus resulted in short term improvement in lung function that is inversely related to pre-treatment FEV1

A comparative study on histopathological features of duodenum, jejunum, and ileum from broiler chicken with avian pathogenic Escherichia coli infection

Avian colibacillosis is a high-prevalence chicken farm disease caused by avian pathogen-ic Escherichia coli (APEC). It is necessary to identify and look up to the bacterial activity to stave off a decline in chicken performance. This study aimed to identify and determine the pathogenetic activity of APEC within broiler chickens on the duodenum, jejunum, and ileum histopathology comparison. The samples were collected from a total of 40 broilers, obtained from a highest-colibacillosis historical chicken house, identified with bacterial isolation swab-technique, and analyzed with nonparametric statistical lesions scoring. The identification result showed 82.5% E. coli with a 62.5% APEC con-firmed. The histopathological feature showed a significant difference (p<0.05), where the jejunum ap-peared to encounter the most significant damage compared to the duodenum and ileum. Thus, it is con-cluded that APEC field infection varies in characteristics and pathogenicity, which affects intestinal organs based on the histology changes, mainly in the jejunum part of the intestine

FACTORS ASSOCIATED WITH TB/HIV CO-INFECTION AMONG DRUG SENSITIVE TUBERCULOSIS PATIENTS MANAGED IN A SECONDARY HEALTH FACILITY IN LAGOS, NIGERIA

Background: This study assessed factors associated with TB/HIV co-infection among TB patients managed in a secondary health facility in Lagos Nigeria. Materials and Methods: A retrospective review of treatment cards of patients seen at a secondary referral hospital between January 1 2014 and December 31 2014 was conducted. Treatment outcomes and factors associated with TB/HIV co-infection were assessed. Results: Of the 334 records of patients reviewed, the proportion of patients with TB/HIV co-infection was 21.6%. The odds of having TB/HIV co-infection was 2.7 times higher among patients above 40 years than patients less than 25 years (AOR 2.7 95% CI 1.1 – 6.5, p =0.030). In addition, the odds of having TB/HIV co-infection was 3.3 higher among extrapulmonary TB cases (AOR 3.3; 95% CI 1.2 – 9.5; p = 0.026) and 2.1 times higher among retreated patients (AOR 2.1; 95% CI 1.1 – 3.9; p = 0.017) than pulmonary TB and new patients respectively. The chance of having TB/HIV co-infection was 2.7-fold more in patients with poor treatment outcomes than patients with treatment success (AOR 2.7; 95%CI 1.3 – 5.4; p =0.006). Conclusion: TB/HIV co-infection rate was high in the study area. There is need to put measures in place to improve treatment outcomes of TB/HIV co-infected patients

Population differentiation and historical demography of the threatened snowy plover Charadrius nivosus (Cassin, 1858)

Delineating conservation units is a complex and often controversial process that is particularly challenging for highly vagile species. Here, we reassess population genetic structure and identify those populations of highest conservation value in the threatened snowy plover (Charadrius nivosus, Cassin, 1858), a partial migrant shorebird endemic to the Americas. We use four categories of genetic data—mitochondrial DNA (mtDNA), microsatellites, Z-linked and autosomal single nucleotide polymorphisms (SNPs)—to: (1) assess subspecies delineation and examine population structure (2) compare the sensitivity of the different types of genetic data to detect spatial genetic patterns, and (3) reconstruct demographic history of the populations analysed. Delineation of two traditionally recognised subspecies was broadly supported by all data. In addition, microsatellite and SNPs but not mtDNA supported the recognition of Caribbean snowy plovers (C. n. tenuirostris) and Floridian populations (eastern C. n. nivosus) as distinct genetic lineage and deme, respectively. Low migration rates estimated from autosomal SNPs (m < 0.03) reflect a general paucity of exchange between genetic lineages. In contrast, we detected strong unidirectional migration (m = 0.26) from the western into the eastern nivosus deme. Within western nivosus, we found no genetic differentiation between coastal Pacific and inland populations. The correlation between geographic and genetic distances was weak but significant for all genetic data sets. All demes showed signatures of bottlenecks occurring during the past 1000 years. We conclude that at least four snowy plover conservation units are warranted: in addition to subspecies nivosus and occidentalis, a third unit comprises the Caribbean tenuirostris lineage and a fourth unit the distinct eastern nivosus deme