Kikuchi-Fujimoto disease: an unusual association with acute renal failure

AbstractKikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis of unknown etiopathogenesis, is a self-limited disease which frequently appears as feverish lymphadenomegaly, thus creating the need for differential diagnosis with lymphoma, systemic lupus erythematosus (SLE), infectious mononucleosis, cat-scratch disease, and toxoplasmosis with lymphonodal impairment. However, there are cases in which it may evolve with complications such as aseptic meningitis, cerebellar ataxia, and aseptic myocarditis. We are presenting a case of a 24-year-old man who had an initial picture of arthralgia, evening fever and adenomegaly. Kikuchi disease was diagnosed through lymph node biopsy with immunohistochemistry and evolves with severe systemic manifestations, such as pericarditis with cardiac tamponade, pneumonitis, hepatitis, and acute kidney failure - the latter has not been reported in literature yet. There was significant improvement of the clinical picture with prednisone

Quercetin pentaacetate inhibits in vitro human respiratory syncytial virus adhesion.

Made available in DSpace on 2020-12-12T01:06:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-15 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Human respiratory syncytial virus (hRSV) is one of the main etiological agents of diseases of the lower respiratory tract and is often responsible for the hospitalization of children and the elderly. To date, treatments are only palliative and there is no vaccine available. Natural products show exceptional structural diversity and they have played a vital role in drug research. Several investigations focused on applied structural modification of natural products to improved metabolic stability, solubility and biological actions them. Quercetin is a flavonoid that presents several biological activities, including anti-hRSV role. Some works criticize the pharmacological use of Quercetin because it has low solubility and low specificity. In this sense, we acetylated Quercetin structure and we used in vitro and in silico assays to compare anti-hRSV function between Quercetin (Q0) and its derivative molecule (Q1). Q1 shows lower cytotoxic effect than Q0 on HEp-2 cells. In addition, Q1 was more efficient than Q0 to protect HEp-2 cells infected with different multiplicity of infection (0.1–1 MOI). The virucidal effects of Q0 and Q1 suggest interaction between these molecules and viral particle. Dynamic molecular results suggest that Q0 and Q1 may interact with F-protein on hRSV surface in an important region to adhesion and viral infection. Q1 interaction with F-protein showed ΔG= -14.22 kcal/mol and it was more stable than Q0. Additional, MTT and plate assays confirmed that virucidal Q1 effects occurs during adhesion step of cycle hRSV replication. In conclusion, acetylation improves anti-hRSV Quercetin effects because Quercetin pentaacetate could interact with F-protein with lower binding energy and better stability to block viral adhesion. These results show alternative anti-hRSV strategy and contribute to drug discovery and development. Universidade Estadual Paulista UNESP (FCLAssis) Universidade Estadual Paulista UNESP IBILCE Centro Multiusuário de Inovação Biomolecular (CMIB) Universidade Estadual Paulista UNESP IBILCE Department of Biology University of Rome Tor Vergata, Via della Ricerca Scientifica 1 Universidade Estadual Paulista UNESP (FCLAssis) Universidade Estadual Paulista UNESP IBILCE Centro Multiusuário de Inovação Biomolecular (CMIB) Universidade Estadual Paulista UNESP IBILCE FAPESP: 2014/12298-

Low-Level Laser Application in the Early Myocardial Infarction Stage Has No Beneficial Role in Heart Failure

Low-level laser therapy (LLLT) has been targeted as a promising approach that can mitigate post infarction cardiac remodeling. There is some interesting evidence showing that the beneficial role of the LLLT could persist long-term even after the end of the application, but it remains to be systematically evaluated. Therefore, the present study aimed to test the hypothesis that LLLT beneficial effects in the early post-infarction cardiac remodeling could remain in overt heart failure even with the disruption of irradiations. Female Wistar rats were subjected to the coronary occlusion to induce myocardial infarction or Sham operation. A single LLLT application was carried out after 60 s and 3 days post-coronary occlusion, respectively. Echocardiography was performed 3 days and at the end of the experiment (5 weeks) to evaluate cardiac function. After the last echocardiographic examination. LV hemodynamic evaluation was performed at baseline and on sudden afterload increases. Compared with the Sham group, infarcted rats showed increased systolic and diastolic internal diameter as well as a depressed shortening fraction of LV. The only benefit of the LLLT was a higher shortening fraction after 3 days of infarction. However, treated-LLLT rats show a lower shortening fraction in the 5th week of study when compared with Sham and non-irradiated rats. A worsening of cardiac function was confirmed in the hemodynamic analysis as evidenced by the higher LV end-diastolic pressure and lower +dP/dt and dP/dt with five weeks of study. Cardiac functional reserve was also impaired by infarction as evidenced by an attenuated response of stroke work index and cardiac output to a sudden afterload stress, without LLLT repercussions. No significant differences were found in the myocardial expression of Akti NEGF pathway. Collectively, these findings illustrate that LLLT improves LV systolic function in the early post-infarction cardiac remodeling. However, this beneficial effect may be dependent on the maintenance of phototherapy. Long-term studies with LLLT application are needed to establish whether these effects ultimately translate into improved cardiac remodeling.Conselho Nacional de Desenvolvimento Cientifico e TecnologicoFAPESPNove de Julho Univ, Lab Biophoton, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Lab Cardiac Physiol, Sao Paulo, SP, BrazilNove de Julho Univ, Program Med, Sao Paulo, BrazilUniv Sao Judas Tadeu, Brazil Phys Educ & Aging Sci Program, Translat Physiol Lab, Sao Paulo, BrazilUniv Fed Sao Paulo, Lab Cardiac Physiol, Sao Paulo, SP, BrazilCNPq: 4400851/2014-8FAPESP: 09-54225/8FAPESP: 15/11028-9Web of Scienc

Kikuchi-Fujimoto disease: an unusual association with acute renal failure

Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis of unknown etiopathogenesis, is a self-limited disease which frequently appears as feverish lymphadenomegaly, thus creating the need for differential diagnosis with lymphoma, systemic lupus erythematosus (SLE), infectious mononucleosis, cat-scratch disease, and toxoplasmosis with lymphonodal impairment. However, there are cases in which it may evolve with complications such as aseptic meningitis, cerebellar ataxia, and aseptic myocarditis. We are presenting a case of a 24-year-old man who had an initial picture of arthralgia, evening fever and adenomegaly. Kikuchi disease was diagnosed through lymph node biopsy with immunohistochemistry and evolves with severe systemic manifestations, such as pericarditis with cardiac tamponade, pneumonitis, hepatitis, and acute kidney failure - the latter has not been reported in literature yet. There was significant improvement of the clinical picture with prednison

Características agronômicas de cultivares de cenoura (Daucus carota L.) submetidas a diferentes lâminas de irrigação

A literatura sobre o desempenho agronômico de hortaliças irrigadas no nordeste sul-mato-grossense ainda é escassa e fundamentada em experiências empíricas de produtores, desprovidos de referências de resultados de pesquisas. Portanto, há necessidade de se determinar o desempenho de novos materiais, que apresentem adequadas características agronômicas, sob irrigação, para maximização da produção. Diante disso, objetivou-se avaliar a produção de diferentes cultivares de cenoura submetidas a diferentes lâminas de irrigação. O experimento foi conduzido em esquema de parcelas subdivididas, tendo nas parcelas quatro lâminas de irrigação (50, 75, 100 e 125% da evapotranspiração da cultura) e nas subparcelas três cultivares de cenoura (Brasília Irecê, Nantes e Nantes Milena), no delineamento em blocos casualizados, com quatro repetições. Foram avaliadas as seguintes características: comprimento da parte aérea, massa seca da parte aérea, comprimento de raiz comercial, diâmetro de raiz comercial, massa de raiz comercial por planta, massa de raiz comercial, massa de raiz não comercial, massa de raiz total e eficiência de uso da água. Os benefícios conferidos pelo aumento das lâminas de irrigação não foram tão efetivos devido aos frequentes eventos de precipitação pluvial ao longo do período experimental; e diante disso, o aumento da lâmina de irrigação não proporcionou benefícios nas características agronômicas das cultivares de cenoura, na época chuvosa, em Chapadão do Sul-MS. A cultivar Brasília Irecê deverá ser preferida para o cultivo de cenoura na região nordeste Sul-Mato-Grossense

Características agronômicas e viabilidade econômica de híbridos de tomateiro irrigado e sob sequeiro

Objetivou-se com o presente trabalho selecionar o híbrido de tomate de mesa mais adaptado a região nordeste do Estado de Mato Grosso do Sul e comparar dois sistemas de cultivo, irrigado e sequeiro. Após levantamento dessas informações, foi realizada a análise econômica para constatação de viabilidade econômica. O experimento foi conduzido em esquema de parcelas subdivididas, tendo nas parcelas, dois sistemas de cultivo (irrigado e sequeiro) e nas subparcelas três híbridos de tomate (Siluet, Lumi e Silvetty), com quatro repetições, no delineamento em blocos casualisados. O tratamento irrigado foi por sistema de gotejamento. Os dados foram submetidos à análise de variância e o teste de médias foi pelo Tukey a 5% de probabilidade. A análise econômica da produção dos três híbridos e nos dois sistemas de cultivo estudados foi feita para áreas de 1 até 10 hectares. A irrigação proporcionou aumento nas produtividades comerciais dos híbridos Siluet e Lumi e na produtividade não comercial do Silvetty. A porcentagem de frutos comerciais do híbrido Silvetty foi maior no sistema em sequeiro. O tomate Siluet apresentou, no geral, desempenho menor em relação aos outros híbridos. A produção do tomate, independente se irrigado ou em sequeiro, apresentou viabilidade em Chapadão do Sul-MS. Concluiu-se que a irrigação, em geral, não proporciona efeito nas características agronômicas do tomateiro, na época chuvosa. Os tomates Lumi e Silvetty devem ser preferidos pelos produtores de tomate do nordeste de Mato Grosso do Sul, e quando esses híbridos são conduzidos em sequeiro, apresentam maior viabilidade econômica

RISK BEHAVIOR FOR BULIMIA AMONG ADOLESCENTS

ABSTRACT Objective: To analyze the risk behavior for bulimia among female adolescents from public and private high schools. Methods: A cross-sectional study with a random sample of 850 female students aged 15-18 years was carried out in a city in northeastern Brazil, using the Bulimic Investigatory Test of Edinburgh (BITE) to assess the risk behavior for bulimia. Data were analyzed using the Statistical Package for the Social Sciences (SPSS) software and the Pearson’s chi-square , Fisher’s exact and robust Poisson regression tests, adopting the significance level of 5%. Results: Less than half of the sample (42.0%) showed standards of dietary risk and weight control practices; in 1.4% of the sample, bulimia signs were already installed. Fear of gaining weight was reported by 62.8% of the subjects. Risk practices were lower among students from public schools; (Odds Ratio - OR - 0.82; confidence interval of 95% - 95%CI - 0.69-0.97). Among restrictive practices, fasting for a whole day was the most applied (29.9% of the students). Among individuals who were at risk situation, almost half believed to have normal eating habits (prevalence ratio - PR - 0.42; 95%CI 0.36-0.49). Individuals who consider their eating habits normal, who are afraid of gaining weight, those who seek emotional comfort in food and follow strict diets had higher risk for bulimia (p<0.05). Conclusions: The number of female adolescent students with risk behavior practices for bulimia is high, and the frequency of those unaware of this situation is also very high. Risk situations emerge as a collective health problem, and individuals from private schools were more likely to be in this situation