Occupational Impact of Caregivers in Pediatric Palliative Care

The purpose of this study is to understand the occupational impact for caregivers who had a child with a life-limiting or life-threatening condition who had received pediatric palliative care. A lack of understanding of occupational therapy’s role in end-of-life care ultimately underutilizes and under-prepares occupational therapists to work in this practice area. Becoming a medical family caregiver, neglecting personal needs and desires becomes a norm having a in-direct effect on physical and psychological health and well-being. Findings from this study suggest that it is reasonable to infer that occupational participation among caregivers is influenced by finding time for self and others, professional and personal sacrifices, multileveled support types, finding meaning and purpose, and engaging in the transformation and healing stages.https://soar.usa.edu/otdcapstonesspring2024/1023/thumbnail.jp

Prevalencia de Caries y Pérdida de Dientes en Población de 65 a 74 Años de Santiago, Chile

AbstractObjectivesTo measure prevalence of caries and tooth loss among low and middle-low socio-economic level elderly from Santiago, Chile.MethodsProportionate stratified probabilistic sampling techniques; sample of 109 people (74 women and 35 men) aged 65 to 74. Data gathered by means of a face-to-face questionnaire. Informed consent was obtained; individuals were examined by a calibrated dentist. The study was carried out from March to December 2008. Data analysis considered chi-square and ANOVA.ResultsDMFT was 24.9 (CI: 23.83; 25.96). All the individuals had caries experience; 45.9% had active caries lesions. The mean of non-treated active caries lesions was 0.9 per individual. Concerning prosthesis, 38.5% of individuals were found to use removable prosthesis and 15 people (13.76%) were edentulous.ConclusionsThe size of the gap and the importance of social environment on damaging oral health should lead to face this problem from a wider perspective of social determinants of health when building public policies

The influence of the project team efficacy and organizational factors on the success of mining project management

Some authors have proposed that project team efficacy influences the success of project management; however, this relationship has not been well investigated. The objectives of this study are to analyze the relationship between project team efficacy and the success of project management and to examine three moderator variables (task uncertainty, task interdependence, and chaos effect) in the relationship between them. This study was based on a sample of 52 mining work teams. The suggested hypotheses were con-firmed, there is an influential relationship between project team efficacy and the success of mining project management, as well as the significance of the moderate variables.Algunos autores han propuesto que la eficacia del equipo del proyecto influye en el ?xito de la gesti?n del proyecto. Sin embargo, esta relaci?n no ha sido bien investigada. Los objetivos de este estudio fueron analizar la relaci?n entre la eficacia del equipo del proyecto y el ?xito de la gesti?n del proyecto y examinar tres variables moderadoras (incertidumbre de la tarea, interdependencia de la tarea y efecto de caos) y la relaci?n entre estas. El estudio se bas? en una muestra de 52 equipos de trabajo minero. Se confirmaron las hip?tesis sugeridas, existe una relaci?n influyente entre la eficacia del equipo del proyecto y el ?xito de la gesti?n del proyecto minero, as? como la importancia de las variables moderadas

The Relationship Between Childhood Physical and Sexual Abuse and Adolescent Cannabis Use: A Systematic Review

Background: Among adolescents, cannabis use is a health concern due to associations with drug addiction and mental health disorders across the life course. It has been shown that childhood maltreatment is associated with drug addiction in adulthood. However, a better understanding of the relationship between maltreatment and drug use may improve targeted prevention and interventions. The aim of this systematic review is to describe the association between exposure to childhood maltreatment, specifically physical and sexual abuse, with adolescent cannabis use. Methods: A systematic search strategy was applied to Embase, PsycINFO, and Ovid MEDLINE(R) databases. Methods followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Abstract and title screening was performed to identify papers which reported an estimate of the association between childhood physical or sexual abuse and adolescent cannabis use. Full text screening of each paper was performed, and data were extracted and study quality assessed. Weighted means meta-analysis was performed on studies reporting odds ratios as effect estimates. Results: Of 8,780 screened articles, 13 were identified for inclusion. Eight papers received a quality rating score indicating lower risk of bias. Eleven papers reported the relationship between childhood sexual abuse and adolescent cannabis use; effect estimates ranged from AOR 0.53-AOR 2.18 (weighted mean OR 1.29, 95% CI 1.08-1.49). The relationship between childhood physical abuse and adolescent cannabis use was reported in 7 papers; effect estimates ranged from AOR 1.25-AOR 1.87 (weighted mean OR 1.39, 95% CI 1.12-1.66). Differences in the strength of the evidence were observed by the method of exposure ascertainment, and there was some evidence of differences in association by gender, age of cannabis initiation, and the severity of the abuse. Conclusions: This systematic review indicates childhood physical or sexual abuse may increase risk of adolescent-onset cannabis use. Few studies considered variation in timing of onset, or by gender. Adolescent cannabis use precedes is strongly associated with increased risk of negative mental health outcomes; further exploration of adolescent cannabis use's place on the causal pathway between childhood abuse and adult mental health problems is warranted to improve intervention

Especies multipropósito perennes con potencial agroforestal en la comunidad Awa, Nariño

La investigación etnobotánica se realizó en el municipio de Ricaurte localizado bajo las coordenadas 1°12′39″ LN 77°59′36″ LO, ubicado a 1810 msnm en el departamento de Nariño. La investigación tuvo como objetivos, la caracterización de los usos de especies perennes multipropósito con potencial agroforestal en la comunidad Awá y la evaluación cuantitativa de las perennes reportadas en el estudio. Para lo cual se emplearon diálogos semi -estructurados y recorridos de campo con informantes claves dentro del grupo; se realizó la clasificación taxonómica y su evaluación cuantitativa mediante tres índices: 1) Valor de Uso de la Especie por Informante (UVsi), 2) Valor de Uso de la Especie (UVs) y 3) Conocimiento Relativo de las Especies por Varios Informantes (RUV). Las 40 especies perennes identificadas en el proyecto, se categorizaron en siete clases de uso, de las cuales el 26 % es para leña, el 21 % para alimento, el 21 % para madera y el 32 % está distribuido en otro tipo de usos y a partir de los índices se determinaron las leñosas más representativas como el guabo (Inga sp.), la guayaba (Psidium guajava L.), el nacedero (Trichanthera gigantea H & B.), y el pomarrosa (Syzygium jambos L.) entre otros. Además, se evidenció la vulnerabilidad que presenta el conocimiento cultural, debido a la pérdida parcial o total dentro de la comunidad indígena, quizás por intereses de otro tipo en las nuevas generaciones, o por influencia de las zonas urbanas aledañas al resguardo indígena

Inverting the handedness of circularly polarized luminescence from light-emitting polymers using film thickness

The emission of circularly polarized light is central to many applications, including data storage, optical quantum computation, biosensing, environmental monitoring, and display technologies. An emerging method to induce (chiral) circularly polarized (CP) electroluminescence from the active layer of polymer light-emitting diodes (polymer OLEDs; PLEDs) involves blending achiral polymers with chiral small-molecule additives, where the handedness/sign of the CP light is controlled by the absolute stereochemistry of the small molecule. Through the in-depth study of such a system we report an interesting chiroptical property: the ability to tune the sign of CP light as a function of active layer thickness for a fixed enantiomer of the chiral additive. We demonstrate that it is possible to achieve both efficient (4.0 cd/A) and bright (8000 cd/m2) CP-PLEDs, with high dissymmetry of emission of both left-handed (LH) and right-handed (RH) light, depending on thickness (thin films, 110 nm: gEL = 0.51, thick films, 160 nm: gEL = -1.05, with the terms "thick" and "thin" representing the upper and lower limits of the thickness regime studied), for the same additive enantiomer. We propose that this arises due to an interplay between localized CP emission originating from molecular chirality and CP light amplification or inversion through a chiral medium. We link morphological, spectroscopic, and electronic characterization in thin films and devices with theoretical studies in an effort to determine the factors that underpin these observations. Through the control of active layer thickness and device architecture, this study provides insights into the mechanisms that result in CP luminescence and high performance from CP-PLEDs, as well as demonstrating new opportunities in CP photonic device design

NCI-MATCH Arms N & P: Phase II study of PI3K beta inhibitor GSK2636771 in patients (pts) with cancers (ca) with PTEN mutation/deletion (mut/del) or PTEN protein loss

Background: The NCI-MATCH trial is the largest national study (1173 sites) for ptswith relapsed/ refractory solid tumors, lymphomas and myeloma, which assigns tar-geted therapies based on individual tumor molecular alterations detected using theadapted Oncomine AmpliSeq panel (143 genes) and immunohistochemistry (IHC).We hypothesized that patients with PTEN-deficient cancers enrolled to Arms N and Pmay benefit from treatment with the PI3K beta-selective inhibitor GSK2636771. Methods: Eligibility: relapsed/refractory ca, good end-organ function, and ECOG PS ≤ 1. Pts were screened for molecular alterations by centralized testing on fresh tumor biopsy and had deleterious PTEN mut/del without loss of expression (Arm N) or complete loss of cytoplasmic and nuclear PTEN staining on IHC (Arm P), and no other aberrations activating the PI3K/MTOR and MAPK pathways (mut in PIK3CA, PIK3R1, BRAF, KRAS, AKT1, TSC1/2, mTOR, RHEB, NF2, NRAS, HRAS). Pts received GSK2636771 400mg/day (28-days cycles). RECIST 1.1 overall response rate (ORR) was the primary endpoint. Results: Of 59 enrolled pts, 56 were eligible and received treatment. Of 22 pts with PTEN mut/del (Arm N: 6 uterine, 2 breast, 2 prostate, 2 head/neck ca, 10 other), all are off treatment as of analysis (14 disease progression, 4 for adverse events [AEs], 4 other). One pt (4.5%) with prostate ca (PTEN deletion, MPRSS2-ERG fusion) attained a partial response (-42%). Of 7 (32%) pts with stable disease (SD), 2 had SD \u3e 6 months (uterine leiomyosarcoma; endometrial carcinoma). Of 34 pts with loss of PTEN protein by IHC (Arm P: 7 prostate, 6 breast, 3 squamous anal ca, 2 cholangiocarcinoma, 16 other), all are off treatment as of analysis (26 disease progression, 4 for AE, 4 other). Of 9 (37.5%) pts with SD, 3 had SD \u3e 6 months (prostate cancer; squamous bladder cancer, squamous anal cancer). Median progression-free survival was 1.8 months for both arms. Gr ≥ 3 treatment-related (tr) reversible toxicities were experienced by 30% (7) and 20% (7) of pts in arms N and P, respectively. No tr Gr 5 toxicities were observed in either arm. Conclusions: Single agent GSK2636771 has very modest activity in ca with PTEN gene mutation/deletion and/or PTEN protein loss