Spectroscopy of broad absorption line quasars at 3≲z≲53\lesssim z \lesssim 5 -- I: evidence for quasar winds shaping broad/narrow emission line regions

We present an observational study of 22 broad absorption line quasars (BAL QSOs) at $3\lesssim z \lesssim5$ based on optical/near-IR spectroscopy, aiming to investigate quasar winds and their effects. The near-IR spectroscopy covers the \hb\ and/or \mgii\ broad emission lines (BELs) for these quasars, allowing us to estimate their central black hole (BH) masses in a robust way. We found that our BAL QSOs on average do not have a higher Eddington ratio than that from non-BAL QSOs matched in redshift and/or luminosity. In a subset consisting of seven strong BAL QSOs possessing sub-relativistic BAL outflows, we see the prevalence of large \civ-BEL blueshift ($\sim$3100 km s$^{-1}$) and weak \oiii\ emission (particularly the narrow \oiii$\lambda$5007 component), indicative of nuclear outflows affecting the narrow emission-line (NEL) regions. In another subset consisting of thirteen BAL QSOs having simultaneous observations of \mgii\ and \hb, we found a strong correlation between 3000~\AA\ and 5000~\AA\ monochromatic luminosity, consistent with that from non-BAL QSOs matched in redshift and luminosity; however, there is no correlation between \mgii\ and \hb\ in FWHM, likely due to nuclear outflows influencing the BEL regions. Our spectroscopic investigations offer strong evidence that the presence of nuclear outflows plays an important role in shaping the BEL/NEL regions of these quasars and possibly, regulating the growth of central supermassive black holes (SMBHs). We propose that BEL blueshift and BAL could be different manifestations of the same outflow system viewed at different sightlines and/or phases.Comment: 13 pages, 10 figures. Accepted for publication in Ap

An ultra-luminous quasar with a twelve-billion-solar-mass black hole at redshift 6.30

So far, roughly 40 quasars with redshifts greater than z=6 have been discovered. Each quasar contains a black hole with a mass of about one billion solar masses ($10^9 M_\odot$). The existence of such black holes when the Universe was less than 1 billion years old presents substantial challenges to theories of the formation and growth of black holes and the coevolution of black holes and galaxies. Here we report the discovery of an ultra-luminous quasar, SDSS J010013.02+280225.8, at redshift z=6.30. It has an optical and near-infrared luminosity a few times greater than those of previously known z>6 quasars. On the basis of the deep absorption trough on the blue side of the Ly $\alpha$ emission line in the spectrum, we estimate the proper size of the ionized proximity zone associated with the quasar to be 26 million light years, larger than found with other z>6.1 quasars with lower luminosities. We estimate (on the basis of a near-infrared spectrum) that the black hole has a mass of $\sim 1.2 \times 10^{10} M_\odot$, which is consistent with the $1.3 \times 10^{10} M_\odot$ derived by assuming an Eddington-limited accretion rate.Comment: 24 pages, 4 figures plus 4 extended data figures, published in Nature on 26 February 201

Unshifted Metastable He I* Mini-Broad Absorption Line System in the Narrow Line Type 1 Quasar SDSS J080248.18++551328.9

We report the identification of an unusual absorption line system in the quasar SDSS J080248.18$+$551328.9 and present a detailed study of the system, incorporating follow-up optical and NIR spectroscopy. A few tens of absorption lines are detected, including He I*, Fe II* and Ni II* that arise from metastable or excited levels, as well as resonant lines in Mg I, Mg II, Fe II, Mn II, and Ca II. All of the isolated absorption lines show the same profile of width $\Delta v\sim 1,500$km s$^{-1}$ centered at a common redshift as that of the quasar emission lines, such as [O II], [S II], and hydrogen Paschen and Balmer series. With narrow Balmer lines, strong optical Fe II multiplets, and weak [O III] doublets, its emission line spectrum is typical for that of a narrow-line Seyfert 1 galaxy (NLS1). We have derived reliable measurements of the gas-phase column densities of the absorbing ions/levels. Photoionization modeling indicates that the absorber has a density of $n_{\rm H} \sim (1.0-2.5)\times 10^5~ {\rm cm}^{-3}$ and a column density of $N_{\rm H} \sim (1.0-3.2)\times 10^{21} \sim {\rm cm}^{-2}$, and is located at $R\sim100-250$ pc from the central super-massive black hole. The location of the absorber, the symmetric profile of the absorption lines, and the coincidence of the absorption and emission line centroid jointly suggest that the absorption gas is originated from the host galaxy and is plausibly accelerated by stellar processes, such as stellar winds \zhy{and/or} supernova explosions. The implications for the detection of such a peculiar absorption line system in an NLS1 are discussed in the context of co-evolution between super-massive black hole growth and host galaxy build-up.Comment: 28 pages, 16 figures; accepted for publication in Astrophysical Journa

An ultra-luminous quasar at z=5.363 with a ten billion solar mass black hole and a Metal-Rich DLA at z~5

We report the discovery of an ultra-luminous quasar J030642.51+185315.8 (hereafter J0306+1853) at redshift 5.363, which hosts a super-massive black hole (SMBH) with $M_{BH} = (1.07 \pm 0.27) \times10^{10}~M_\odot$. With an absolute magnitude $M_{1450}=-28.92$ and bolometric luminosity $L_{bol}\sim3.4\times10^{14} L_{\odot}$, J0306+1853 is one of the most luminous objects in the early Universe. It is not likely to be a beamed source based on its small flux variability, low radio loudness and normal broad emission lines. In addition, a $z=4.986$ Damped Ly$\alpha$ system (DLA) with $\rm [M/H]=-1.3\pm0.1$, among the most metal rich DLAs at $z \gtrsim 5$, is detected in the absorption spectrum of this quasar. This ultra-luminous quasar puts strong constraint on the bright-end of quasar luminosity function and massive-end of black hole mass function. It will provide a unique laboratory to the study of BH growth and the co-evolution between BH and host galaxy with multi-wavelength follow-up observations. The future high resolution spectra will give more insights to the DLA and other absorption systems along the line-of-sight of J0306+1853.Comment: 5 pages, 3 figures, accepted for publication in ApJ

An agent-based hardware-in-the-loop simulation framework for building controls

In general, a hardware-in-the-loop (HIL) building simulation has lower cost and fewer practical limitations (e.g., scheduling issues) than field tests in occupied buildings, while also overcoming limitations of simulations alone by capturing the full behavior of some physical systems, equipment, and components. However, the implementation of an HIL can be difficult due to the scarcity of appropriate tools. This paper presents an agent-based framework for HIL simulation. It can be used for investigation of controller performance via controller-in-the-loop simulations and also HIL for system synthesis. In the latter case, both controllers and major equipment participate in tests to ensure that dynamics of equipment operation are correctly captured in addition to controller performance. The HIL simulation framework presented allows such actual physical parts to be included in the framework while representing others for which behaviors are better known and modeled in simulation models. The mechanism implemented in the framework to synchronize simulations in software with real-time operation of physical equipment is described. As an example, use of the HIL simulation framework is illustrated through a brief study of speed control of the supply fan in the air handling unit of a variable-air-volume building heating, ventilating and air-conditioning system.</p

A SURVEY OF LUMINOUS HIGH-REDSHIFT QUASARS WITH SDSS AND WISE. II. THE BRIGHT END OF THE QUASAR LUMINOSITY FUNCTION AT z similar to 5

This is the second paper in a series on a new luminous z ~ 5 quasar survey using optical and near-infrared colors. Here we present a new determination of the bright end of the quasar luminosity function (QLF) at z ~ 5. Combining our 45 new quasars with previously known quasars that satisfy our selections, we construct the largest uniform luminous z ~ 5 quasar sample to date, with 99 quasars in the range of 4.7 ≤ z < 5.4 and −29 < M 1450 ≤ −26.8, within the Sloan Digital Sky Survey (SDSS) footprint. We use a modified 1/V a method including flux limit correction to derive a binned QLF, and we model the parametric QLF using maximum likelihood estimation. With the faint-end slope of the QLF fixed as α = −2.03 from previous deeper samples, the best fit of our QLF gives a flatter bright end slope β = −3.58 ± 0.24 and a fainter break magnitude ${M}_{1450}^{* }$ = −26.98 ± 0.23 than previous studies at similar redshift. Combined with previous work at lower and higher redshifts, our result is consistent with a luminosity evolution and density evolution model. Using the best-fit QLF, the contribution of quasars to the ionizing background at z ~ 5 is found to be 18%–45% with a clumping factor C of 2–5. Our sample suggests an evolution of radio loud fraction with optical luminosity but no obvious evolution with redshift

Anti-PD-1 immunotherapy combined with stereotactic body radiation therapy and GM-CSF for the treatment of advanced malignant PEComa: A case report

BackgroundPerivascular epithelioid cell neoplasm (PEComa) is a rare mesenchymal tumour. Due to its low incidence, a standard treatment regimen for PEComa has not yet been established. Radiotherapy has a synergistic effect with PD-1 inhibitors and GM-CSF. We treated advanced malignant PEComa with a triple regimen of PD-1 inhibitor, SBRT and GM-CSF to provide better therapeutic effect.Case presentationA 63-year-old woman was diagnosed with malignant PEComa after presenting with postmenopausal vaginal bleeding. Despite two surgeries, the neoplasm eventually metastasized throughout the body. We formulated triple therapy with SBRT, a PD-1 inhibitor, and GM-CSF for the patient. The patient’s local symptoms were controlled at the radiotherapy site, and the lesions at the unirradiated sites were also relieved.ConclusionsFor the first time, a triple regimen of PD-1 inhibitor, SBRT and GM-CSF was used in the treatment of malignant PEComa and achieved good efficacy. Considering the lack of prospective clinical studies in PEComa, we believe that this triple therapy is a good-quality regimen for advanced malignant PEComa

The physical constraints on a new LoBAL QSO at z=4.82

Very few low-ionization broad absorption line (LoBAL) QSOs have been found at high redshifts to date. One high-redshift LoBAL QSO, J0122+1216, was recently discovered at the Lijiang 2.4-m Telescope with an initial redshift determination of 4.76. Aiming to investigate its physical properties, we carried out follow-up observations in the optical and near-IR spectroscopy. Near-IR spectra from UKIRT and P200 confirms that it is a LoBAL, with a new redshift determination of $4.82\pm0.01$ based on the \mgii~ emission-line. The new \mgii~ redshift determination reveals strong blueshifts and asymmetry of the high-ionization emission lines. We estimated a black hole mass of $\sim 2.3\times 10^9 M_\odot$ and Eddington ratio of $\sim 1.0$ according to the empirical \mgii-based single-epoch relation and bolometric correction factor. It is possible that strong outflows are the result of an extreme quasar environment driven by the high Eddington ratio. A lower limit on the outflowing kinetic power ($>0.9\% L_{Edd}$) was derived from both emission and absorption lines, indicating these outflows play a significant role in the feedback process to regulate the growth of its black hole as well as host galaxy evolution.Comment: 12 pages, 10 figures. Accepted for publication in The Astrophysical Journa

Integrated bioinformatics identifies key mediators in cytokine storm and tissue remodeling during Vibrio mimicus infection in yellow catfish (Pelteobagrus fulvidraco)

IntroductionThe pathogenesis of Vibrio mimicus infection in yellow catfish (Pelteobagrus fulvidraco) remains poorly understood, particularly regarding the impact of infection with the pathogen on primary target organs such as the skin and muscle.MethodsIn this study, we aim to analyze the pathological intricacies of the skin and muscle of yellow catfish after being infected with V. mimicus using a 1/10 LC50 seven-day post-infection model. Furthermore, we have utilized integrated bioinformatics to comprehensively elucidate the regulatory mechanisms and identify the key regulatory genes implicated in this phenomenon.ResultsOur histopathological examination revealed significant pathological changes in the skin and muscle, characterized by necrosis and inflammation. Moreover, tissue remodeling occurred, with perimysium degeneration and lesion invasion into the muscle along the endomysium, accompanied by a transformation of type I collagen into a mixture of type I and type III collagens in the perimysium and muscle bundles. Our eukaryotic transcriptomic and 4D label-free analyses demonstrated a predominantly immune pathway response in both the skin and muscle, with downregulation observed in several cell signaling pathways that focused on focal adhesion-dominated cell signaling pathways. The upregulated genes included interleukins (IL)-1 and -6, chemokines, and matrix metallopeptidases (mmp)-9 and -13, while several genes were significantly downregulated, including col1a and col1a1a. Further analysis revealed that these pathways were differentially regulated, with mmp-9 and mmp-13 acting as the potential core regulators of cytokine and tissue remodeling pathways. Upregulation of NF-κB1 and FOSL-1 induced by IL-17C and Nox 1/2-based NADPH oxidase may have held matrix metallopeptidase and cytokine-related genes. Also, we confirmed these relevant regulatory pathways by qPCR and ELISA in expanded samples.DiscussionOur findings unequivocally illustrate the occurrence of a cytokine storm and tissue remodeling, mediated by interleukins, chemokines, and MMPs, in the surface of yellow catfish infected with V. mimicus. Additionally, we unveil the potential bidirectional regulatory role of MMP-9 and MMP-13. These results provide novel perspectives on the intricate immune response to V. mimicus infection in yellow catfish and highlight potential targets for developing therapies

Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project Consortium

Although there is a clear relationship between family history (FH) and the risk of gastric cancer (GC), quantification is still needed in relation to different histological types and anatomical sites, and in strata of covariates. The objective was to analyze the risk of GC according to first-degree FH in a uniquely large epidemiological consortium of GC. This investigation includes 5946 cases and 12,776 controls from 17 studies of the Stomach Cancer Pooling (StoP) Project consortium. Summary odds ratios (OR) and the corresponding 95% confidence intervals (CIs) were calculated by pooling study-specific ORs using fixed-effect model meta-analysis techniques. Stratified analyses were carried out by sex, age, tumor location and histological type, smoking habit, socioeconomic status, alcohol intake and fruit consumption. The pooled OR for GC was 1.84 (95% CI: 1.64-2.04; I2 = 6.1%, P heterogeneity = 0.383) in subjects with vs. those without first-degree relatives with GC. No significant differences were observed among subgroups of sex, age, geographic area or study period. Associations tended to be stronger for non-cardia (OR = 1.82; 95% CI: 1.59-2.05 for subjects with FH) than for cardia GC (OR = 1.38; 95% CI: 0.98-1.77), and for the intestinal (OR = 1.92; 95% CI: 1.62-2.23) than for the diffuse histotype (OR = 1.62; 95% CI: 1.28-1.96). This analysis confirms the effect of FH on the risk of GC, reporting an approximately doubled risk, and provides further quantification of the risk of GC according to the subsite and histotype. Considering these findings, accounting for the presence of FH to carry out correct prevention and diagnosis measures is of the utmost importance