Is mastectomy an option in treatment of breast abscesses?

Three cases of severe breast infection are presented. The first patient was admitted with a gangrenous left breast and was in septic shock. She died soon after admission. Thc second case had bilateral breast abscesses and was toxic. She also died after treatment with antibiotics and multiple debridments. The third patient with bilateral severe breast infection had right mastectomy. She made a rapid improvement. It is proposed that mastectomy may be a reasonable option for management of advanced or neglected breast infection or necrotising fasciitis of the breast.Key words: hlastectomj; option, treatment and breast absces

Thermodynamic effects of temperature during roasting of chromite for sodium chromate salts formation

This paper aims to assess the potential effects of roasting temperature on the formation of sodium chromate (Na2CrO4). To perform this task, chromite samples were complexed with NaCl at temperatures ranging from 900 °C to 1 200 °C in the presence of excess oxygen. These experimental conditions were set and assessed based on the predicted phase transformations using Facstage as a prediction tool. The scanning electron microscopy and energy dispersive spectroscopy (SEM-EDS) have revealed the roasting behaviour of chromite to be governed by a fully reacted outside layer and an unreacted core. As per the x-ray diffraction (XRD) results, at lower temperature settings, mineral phases such as hematite and chromium oxide reported as an indication of predicted oxidation of chromite. The key results indicate that the addition of NaCl reduces the equilibrium temperature, thereby fully decomposing the stable and refractory spinel structure of chromite at 1 200 °C

Violence as an impediment to a culture of teaching and learning in some South African schools

School violence in South Africa has a long history. Despite the introduction of a new democratic political dispensation in 1994, it appears that violence in schools has not abated. School violence unfortunately impacts negatively on a culture of learning and teaching. In this project, the nature and extent of violence in schools among a sample of learners was investigated. It was found inter alia that school violence has indeed remained a serious problem among these learners and has impacted deleteriously on the culture of teaching and learning in their schools. Two solutions for the eradication of the problem are suggested. South African Journal of Education Vol.24(2) 2004: 170-17

The Identification of Sustainability Assessment Indicators for Road Infrastructure Projects in Tanzania

The performance of sustainability in infrastructure projects continues to face challenges in its implementation and attainment in developing countries, one of which is the lack of appraisal tools and indicators for the assessment of sustainability. Studies indicate that there are no formal indicators for sustainability assessment on road infrastructure projects in Tanzania, the lack of which limits the determination of whether projects implemented are sustainable or not. Therefore, this study aimed at determining the key sustainability assessment indicators used for road infrastructure projects in Tanzania. A concurrent mixed research approach was adopted in which the sample was purposively selected. A content analysis and descriptive statistics using the Statistical Package for the Social Sciences (SPSS 20.0) were used to analyze qualitative and quantitative data, respectively. The findings indicate that 24 indicators are applicable to Tanzania. Among the highly ranked include “health and safety training to workers”, “health and safety personnel in the project team”, “site barriers and safety warning signs”, “personal protective equipment (PPE) provision”, and “waste collection”. The qualitative results further support the identified sustainability assessment indicators on road infrastructure projects in Tanzania, with one new indicator of “air quality” emerging. The findings inform the government and other relevant stakeholders in the construction industry including planners, designers, and project managers of the key sustainability assessment indicators for roads, which would influence regulation as well as policies to improve the sustainability performance of road projects in Tanzania

Assessment of the Effect of the Oral Iron Chelator Deferiprone on Asymptomatic Plasmodium Falciparum Parasitemia in Humans

While the parenteral iron-chelating agent desferrioxamine B has anti- malarial activity in humans, the usefulness of an orally active chelator for this indication has not been investigated previously in vivo. We conducted a prospective, double-blind, placebo-controlled, cross-over trial of deferiprone (L1; CP20; 1,2-dimethyl-3-hydroxypyridin-4-one) in 25 adult Zambians with asymptomatic Plasmodium falciparum parasitemia. Deferiprone was administered daily for three or four days in divided doses of 75 or 100 mg/kg of body weight, dosages that are effective for treating iron overload. No reduction in asexual intra-erythrocytic parasites was observed during or after deferiprone treatment. The mean peak plasma concentration of deferiprone (108.9 ± 24.9 μmol/L) achieved was within the range demonstrated to inhibit the growth of P. falciparum in vitro, but the systemic exposure as determined by the 24-hr plasma concentration-time curve would not be predicted inhibit growth in vivo. No evidence of deferiprone- associated hematological toxicity was noted in this short-term study of these subjects, all of whom had clinical evidence of normal body iron stores. Because of the risk of neutropenia and other adverse effects with higher doses or prolonged use of the chelator, additional trials of deferiprone as a sole anti-malarial agent would not seem to be justified. In contrast, further efforts are needed to develop other orally active iron-chelating agents specifically for their antimalarial action

Gastric Malignancy Survival in Zambia, Southern Africa: A two year follow up study

Background: Gastric cancer poses a significant global health burden. It is the second most common cause of cancer death worldwide and the ninth leading cause of cancer mortality in Zambia, at a rate of 3.8/100,000; comparable to USA (2/100,000) and UK (3.4/100,000). Survival data on gastric malignancy in Zambia is not known.Objectives: To provide preliminary survival rates of patients with histologically proven gastric adenocarcinoma in Zambia.Study Design: Using our prospective gastric cancer research database, we conducted a retrospective audit of patients diagnosed with gastric cancer at the University Teaching Hospital, Zambia, from June 2010 until January 2012. We contacted patients or their relatives using phone numbers provided at time of enrollment.Main Outcomes: We reviewed age, sex, demographic data (income, education), body mass index, symptoms, duration of symptoms, treatment (surgery, chemotherapy, radiotherapy or combination) and survival outcome.  Analysis was performed using Kaplan-Meier models and log rank test.Results: Fifty one patients were diagnosed with gastric adenocarcinoma during the study period, but follow-up data were available for 50. Median survival was 142 days. Age, sex, income, education, BMI, tumor location, and treatment modality were not significantly associated with overall survival. In Cox regression models, covariates associated with survival were a history of regular alcohol intake (HR 0.49, 95%CI 0.26,0.92; P=0.025) and intestinal type cancer histology (HR 0.40, 95%CI 0.19,0.83; P=0.01).Conclusion: Prognosis of newly diagnosed gastric cancer in Zambia is poor with significant mortality within 1 yearof diagnosis, particularly among patients with weight loss and dysphagia

Self-efficacy enhanced in a cross-cultural context through an initiative in under-resourced schools in KwaZulu-Natal, South Africa

This paper discusses the Khanyisa Programme, an initiative in KwaZulu-Natal, South Africa, where learners from under-resourced schools are supported by teachers and high achievers in Grade 11 and 12 from a previously advantaged state school under apartheid. A qualitative, evaluative study was undertaken to identify key elements in the ongoing success of the programme and collect participant suggestions for improvement. The findings, discussed within the framework of self-efficacy theory, identified enormous gains by Khanyisa learners, leading to vastly improved career prospects