Performance of PLS regression coefficients in selecting variables for each response of a multivariate PLS for omics-type data

Multivariate partial least square (PLS) regression allows the modeling of complex biological events, by considering different factors at the same time. It is unaffected by data collinearity, representing a valuable method for modeling high-dimensional biological data (as derived from genomics, proteomics and peptidomics). In presence of multiple responses, it is of particular interest how to appropriately “dissect” the model, to reveal the importance of single attributes with regard to individual responses (for example, variable selection). In this paper, performances of multivariate PLS regression coefficients, in selecting relevant predictors for different responses in omics-type of data, were investigated by means of a receiver operating characteristic (ROC) analysis. For this purpose, simulated data, mimicking the covariance structures of microarray and liquid chromatography mass spectrometric data, were used to generate matrices of predictors and responses. The relevant predictors were set a priori. The influences of noise, the source of data with different covariance structure and the size of relevant predictors were investigated. Results demonstrate the applicability of PLS regression coefficients in selecting variables for each response of a multivariate PLS, in omics-type of data. Comparisons with other feature selection methods, such as variable importance in the projection scores, principal component regression, and least absolute shrinkage and selection operator regression were also provided

Healthy Eating, Activity, Reinforcement, and Training (HEART): A Program for The Meeting Place Clubhouse

An assessment of HEART program which includes... - Program Design & Methodology - Social Marketing Plan - Evaluation Plan - Budgethttps://digital.sandiego.edu/npi-bpl-programdesign/1002/thumbnail.jp

A dispersion theoretical approach to the threshold amplitudes of pion photoproduction

We give predictions for the partial wave amplitudes of pion photoproduction near threshold by means of dispersion relations at fixed t. The free parameters of this approach are determined by a fit to experimental data in the energy range 160 MeV $\le E_{\gamma} \le$ 420 MeV. The observables near threshold are found to be rather sensitive to the amplitudes in the resonance region, in particular to the $\Delta$ (1232) and $N^*$ (1440). We obtain a good agreement with the existing threshold data for both charged and neutral pion production. Our predictions also agree well with the results of chiral perturbation theory, except for neutral pion production off the neutron.Comment: 16 pages LATEX including 4 postscript figure

The position and the residues of the delta resonance pole in pion photoproduction

We have analyzed the $M_{1+}^{(3/2)}$ and $E_{1+}^{(3/2)}$ multipole amplitudes of pion photoproduction in the framework of fixed-$t$ dispersion relations. Applying the speed plot technique to our results for these multipoles, we have determined the position and the residues of the $\Delta$ (1232) resonance pole. The pole is found at total $c.m.$ energy $W = (1211 - 50i)$ MeV on the second Riemann sheet, and the ratio of the electric and magnetic residues is $R_{\Delta} = - 0.035 - 0.046 i$, resulting in an E2/M1 ratio for the "dressed" delta resonance of $- 3.5 \%$.Comment: 16 pages LATEX including 5 postscript figures in a self-extracting uufile archiv

Практический опыт развития комплексной системы экологического просвещения в образовательной организации

В статье представлены разработанные и апробированные в образовательной организации новые подходы, механизмы и инструменты по одному из приоритетных направлений развития страны в части формирования экологического культуры вузовской молодежи с целью повышения познавательной активности, уровня экологических знаний в области гармоничного развития человека и природы, устойчивого интереса к экологическим проблемам современности, воспитания и привития бережного отношения к окружающей природе.The article presents new approaches, mechanisms and tools developed and tested in the educational organization in one of the priority directions of the country's development in terms of forming the ecological culture of university youth in order to increase cognitive activity, the level of ecological knowledge in the field of harmonious development of man and nature, and a steady interest in environmental problems of modernity, upbringing and inculcation of respect for nature

A unitary isobar model for pion photo- and electroproduction on the proton up to 1 GeV

A new operator for pion photo- and electroproduction has been developed for nuclear applications at photon equivalent energies up to 1 GeV. The model contains Born terms, vector mesons and nucleon resonances ($P_{33}(1232)$, $P_{11}(1440)$, $D_{13}(1520)$, $S_{11}(1535)$, $F_{15}(1680)$, and $D_{33}(1700)$). The resonance contributions are included taking into account unitarity to provide the correct phases of the pion photoproduction multipoles. The $Q^2$ dependence of electromagnetic resonance vertices is described with appropriate form factors in the electromagnetic helicity amplitudes. Within this model we have obtained good agreement with the experimental data for pion photo- and electroproduction on the nucleon for both differential cross sections and polarization observables. The model can be used as a starting point to predict and analyze forthcoming data.Comment: 32 pages LaTeX including 23 postscript figures (a few misprints have been corrected

Multipole analysis of pion photoproduction based on fixed t dispersion relations and unitarity

We have analysed pion photoproduction imposing constraints from fixed t dispersion relations and unitarity. Coupled integral equations for the S and P wave multipoles were derived from the dispersion relations and solved by the method of Omnes and Muskhelishvili. The free parameters were determined by a fit to the most recent data for \pi^{+} and \pi^{0} production on the proton as well as \pi^{-} production on the neutron, in the energy We have analysed pion photoproduction imposing constraints from fixed t dispersion relations and unitarity. Coupled integral equations for the S and P wave multipoles were derived from the dispersion relations and solved by the method of Omnes and Muskhelishvili. The free parameters were determined by a fit to the most recent data for \pi^{+} and \pi^{0} production on the proton as well as \pi^{-} production on the neutron, in the energy range 160 MeV \leq E_{\gamma} \leq 420 MeV. The lack of high precision data on the neutron and of polarization observables leads to some limitations of our results. Especially the multipole M_{1-} connected with the Roper resonance P_{11}(1440) cannot be determined to the required precision. Our predictions for the threshold amplitudes are in good agreement with both the data and chiral perturbation theory. In the region of the \Delta(1232) we have determined the ratio of electric quadrupole and magnetic dipole excitation. The position of the resonance pole is obtained in excellent agreement with pion-nucleon scattering, and the complex residues of the multipoles are determined with the speed-plot technique.Comment: 46 pages LATEX including 29 postscript figure

Plasma proteins predict conversion to dementia from prodromal disease.

PublishedJournal ArticleMulticenter StudyResearch Support, Non-U.S. Gov'tBACKGROUND: The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia. METHODS: Three multicenter cohorts of cognitively healthy elderly, mild cognitive impairment (MCI), and AD participants with standardized clinical assessments and structural neuroimaging measures were used. Twenty-six candidate proteins were quantified in 1148 subjects using multiplex (xMAP) assays. RESULTS: Sixteen proteins correlated with disease severity and cognitive decline. Strongest associations were in the MCI group with a panel of 10 proteins predicting progression to AD (accuracy 87%, sensitivity 85%, and specificity 88%). CONCLUSIONS: We have identified 10 plasma proteins strongly associated with disease severity and disease progression. Such markers may be useful for patient selection for clinical trials and assessment of patients with predisease subjective memory complaints.Medical Research Council (MRC)Alzheimer’s Research UKThe National Institute for Health Research (NIHR) Biomedical Research CentreBiomedical Research Unit for DementiaAddNeuroMed through the EU FP6 programInnovative Medicines Initiative Joint Undertaking under an EMIF grantEuropean Union’s Seventh Framework Programme (FP7/2007-2013

Pattern of mRNA expression of β-defensins in basal cell carcinoma

BACKGROUND: Although the human β-defensins hBDs today seem to have diverse functional activities in innate antimicrobial immunity, a few reports also indicated an altered expression of these antimicrobial peptides (AMPs) in tissues of cancers such as oral squamous cell carcinoma. The present work was aimed on the study of hBD gene expression in basal cell carcinoma (BCC) which is the most common cancer in humans. METHODS: Twenty-two non-ulcerated BCCs (12 nodular type, 10 superficial type) have been analysed for the presence of hBD (1–3) mRNA by quantitative real-time RT-PCR. As controls, non-lesional skin specimens of BCC patients as well as samples of healthy subjects were assessed by RT-PCR. RESULTS: hBD-1 levels in healthy controls and non-lesional skin of BCC patients were significantly (P < 0.05) higher than the levels observed in tumour tissue. Moreover, BCCs showed significantly (P < 0.05) increased mRNA expression of hBD-2 as compared to controls. There was no significant (P > 0.05) difference between lesional mRNA levels for hBD-3 and those levels observed in controls. The mRNA expression of hBDs (1–3) found in nodular and superficial BCCs did not significantly (P > 0.05) differ. CONCLUSION: The gene expression patterns of hBD-1 and hBD-2 are for the first time shown to be significantly altered in non-ulcerated BCCs as compared to intra-individual and inter-individual controls, respectively. The present findings may indicate that beside the antimicrobial activity of AMPs, hBDs may also play a role in the pathogenesis of BCC. However, functional and immunohistological studies investigating hBDs in patients with BCC are needed to confirm our data