1,931 research outputs found
A topological transformation in evolutionary tree search methods based on maximum likelihood combining p-ECR and neighbor joining
Modeling and simulation of the horizontal component of the geomagnetic field by fractional stochastic differential equations in conjunction with empirical mode decomposition
In this paper, we investigate the characteristics and develop a stochastic model for the horizontal component B-x of the magnetic field at 22 stations of the global near-real-time magnetic observatory network INTERMAGNET. The model is in the form of a fractional stochastic differential equation. A method to estimate the parameters on the basis of observed data and to simulate the data using the model is given. The degree of fractional differentiation and the alpha-stability exponent of the process are employed to cluster the stations. The B-x time series possess pronounced local trends, which must be removed before modeling and simulation can be performed. This trend removal is carried out by an empirical mode decomposition. An outcome is an efficient method to simulate the B-x time series by empirical mode decomposition and fractional stochastic differential equation. The numerical results indicate the existence of two distinct clusters of the INTERMAGNET: one in the mid- and low latitudes consistent with the D-st index, and the other above geomagnetic latitude 60 degrees N consistent with the AE index. This clustering corresponds to the inner magnetosphere and the outer magnetosphere, respectively
Human Pol II promoter recognition based on primary sequences and free energy of dinucleotides
<p>Abstract</p> <p>Background</p> <p>Promoter region plays an important role in determining where the transcription of a particular gene should be initiated. Computational prediction of eukaryotic Pol II promoter sequences is one of the most significant problems in sequence analysis. Existing promoter prediction methods are still far from being satisfactory.</p> <p>Results</p> <p>We attempt to recognize the human Pol II promoter sequences from the non-promoter sequences which are made up of exon and intron sequences. Four methods are used: two kinds of multifractal analysis performed on the numeric sequences obtained from the dinucleotide free energy, Z curve analysis and global descriptor of the promoter/non-promoter primary sequences. A total of 141 parameters are extracted from these methods and categorized into seven groups (methods). They are used to generate certain spaces and then each promoter/non-promoter sequence is represented by a point in the corresponding space. All the 120 possible combinations of the seven methods are tested. Based on Fisher's linear discriminant algorithm, with a relatively smaller number of parameters (96 and 117), we get satisfactory discriminant accuracies. Particularly, in the case of 117 parameters, the accuracies for the training and test sets reach 90.43% and 89.79%, respectively. A comparison with five other existing methods indicates that our methods have a better performance. Using the global descriptor method (36 parameters), 17 of the 18 experimentally verified promoter sequences of human chromosome 22 are correctly identified.</p> <p>Conclusion</p> <p>The high accuracies achieved suggest that the methods of this paper are useful for understanding the difficult problem of promoter prediction.</p
Angular Reconstruction of a Lead Scintillating-Fiber Sandwiched Electromagnetic Calorimeter
A new method called Neighbor Cell Deposited Energy Ratio (NCDER) is proposed
to reconstruct incidence position in a single layer for a 3-dimensional imaging
electromagnetic calorimeter (ECAL).This method was applied to reconstruct the
ECAL test beam data for the Alpha Magnetic Spectrometer-02 (AMS-02). The
results show that this method can achieve an angular resolution of 7.36\pm 0.08
/ \sqrt(E) \oplus 0.28 \pm 0.02 degree in the determination of the photons
direction, which is much more precise than that obtained with the
commonly-adopted Center of Gravity(COG) method (8.4 \pm 0.1 /sqrt(E) \oplus
0.8\pm0.3 degree). Furthermore, since it uses only the properties of
electromagnetic showers, this new method could also be used for other type of
fine grain sampling calorimeters.Comment: 6 pages, 8 figure
Above-knee Prosthesis Control Based on Posture Recognition by Support Vector Machine
Abstract-In order for individuals suffering from transfemoral amputation to walk in a variety of circumstances, the above-knee prosthesis based on posture recognition was presented. The body posture of lower limb was classified into four classes, "stair", "sitting", "standing", and "walking". For measure the amputee's movement intent, surface EMG signals which can reflect amputee's movement intent and can be measured without invasion were applied to identify postural adjustments by support vector machine. The result of this study indicates that this method can recognize every postural adjustment with a higher identification rate, and has a great potential in practical application of artificial lower limb
Simultaneous electrical-field-effect modulation of both top and bottom Dirac surface states of epitaxial thin films of three-dimensional topological insulators
It is crucial for the studies of the transport properties and quantum effects
related to Dirac surface states of three-dimensional topological insulators (3D
TIs) to be able to simultaneously tune the chemical potentials of both top and
bottom surfaces of a 3D TI thin film. We have realized this in molecular beam
epitaxy-grown thin films of 3D TIs, as well as magnetic 3D TIs, by fabricating
dual-gate structures on them. The films could be tuned between n-type and
p-type by each gate alone. Combined application of two gates can reduce the
carrier density of a TI film to a much lower level than with only one of them
and enhance the film resistance by 10000 %, implying that Fermi level is tuned
very close to the Dirac points of both top and bottom surface states without
crossing any bulk band. The result promises applications of 3D TIs in field
effect devices.Comment: 19 pages, 4 figures, accepted by Nano Letters, forthcomin
Prognostic Value of Metastatic No.8p LNs in Patients with Gastric Cancer
Background. To evaluate prognostic value of metastatic No.8p LNs in patients with gastric cancer. Methods. From August 2002 to December 2011, a total of 284 gastric cancer patients who underwent gastrectomy with No.8p LNs dissection were analyzed retrospectively in this study. Patients were divided into two groups according to the status of No.8p LNs. Clinicopathological features were collected to conduct the correlation analysis. Follow-up was carried out up to December 31st, 2014. Overall survival was analyzed. Results. Out of 284 patients, metastatic No.8p LNs were found in 24 (8.5%) patients. Compared with other 260 cases, these patients suffered morphologically larger tumor (P=0.003), node stage (P=0.000), and metastatic stage (P=0.000). The 3-year overall survival rate was 26% in No.8p-positive group and 53% in No.8p-negative group. No significant difference of cumulative survival rates existed between the No.8p-positive group and No.8p-negative stage IV group (26% versus 28%, P=0.923). Patients with other distant metastasis or not in No.8p+ group had similar cumulative survival rates (24% versus 28%, P=0.914). Conclusions. Positive No.8p LNs were a poor but not an independent prognostic factor for patients with GC and should be recognized as distant metastasis
Antidiabetic Effect of Salvianolic Acid A on Diabetic Animal Models via AMPK Activation and Mitochondrial Regulation
Physical properties and chemical composition of the cores in the California molecular cloud
We aim to reveal the physical properties and chemical composition of the
cores in the California molecular cloud (CMC), so as to better understand the
initial conditions of star formation. We made a high-resolution column density
map (18.2") with Herschel data, and extracted a complete sample of the cores in
the CMC with the \textsl{fellwalker} algorithm. We performed new
single-pointing observations of molecular lines near 90 GHz with the IRAM 30m
telescope along the main filament of the CMC. In addition, we also performed a
numerical modeling of chemical evolution for the cores under the physical
conditions. We extracted 300 cores, of which 33 are protostellar and 267 are
starless cores. About 51\% (137 of 267) of the starless cores are prestellar
cores. Three cores have the potential to evolve into high-mass stars. The
prestellar core mass function (CMF) can be well fit by a log-normal form. The
high-mass end of the prestellar CMF shows a power-law form with an index
that is shallower than that of the Galactic field stellar
mass function. Combining the mass transformation efficiency ()
from the prestellar core to the star of and the core formation
efficiency (CFE) of 5.5\%, we suggest an overall star formation efficiency of
about 1\% in the CMC. In the single-pointing observations with the IRAM 30m
telescope, we find that 6 cores show blue-skewed profile, while 4 cores show
red-skewed profile. []/[HNC] and []/ in protostellar cores are higher than those in prestellar cores;
this can be used as chemical clocks. The best-fit chemical age of the cores
with line observations is ~years.Comment: Accepted by Astronomy & Astrophysics (A&A
- …