51 research outputs found

    Daily ensemble river discharge reforecasts and real-time forecasts from the operational Global Flood Awareness System

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    Operational global-scale hydrological forecasting systems are used to help manage hydrological extremes such as floods and droughts. The vast amounts of raw data that underpin forecast systems and the ability to generate information on forecast skill have, until now, not been publicly available. As part of the Global Flood Awareness System (GloFAS; https://www.globalfloods.eu/, last access: 3 December 2022) service evolution, in this paper daily ensemble river discharge reforecasts and real-time forecast datasets are made free and openly available through the Copernicus Climate Change Service (C3S) Climate Data Store (CDS). They include real-time forecast data starting on 1 January 2020 updated operationally every day and a 20-year set of reforecasts and associated metadata. This paper describes the model components and configuration used to generate the real-time river discharge forecasts and the reforecasts. An evaluation of ensemble forecast skill using the continuous ranked probability skill score (CRPSS) was also undertaken for river points around the globe. Results show that GloFAS is skilful in over 93 % of catchments in the short (1 to 3 d) and medium range (5 to 15 d) against a persistence benchmark forecast and skilful in over 80 % of catchments out to the extended range (16 to 30 d) against a climatological benchmark forecast. However, the strength of skill varies considerably by location with GloFAS found to have no or negative skill at longer lead times in broad hydroclimatic regions in tropical Africa, western coast of South America, and catchments dominated by snow and ice in high northern latitudes. Forecast skill is summarised as a new headline skill score available as a new layer on the GloFAS forecast Web Map Viewer to aid user interpretation and understanding of forecast quality.</p

    Selective Attenuation of Norepinephrine Release and Stress-Induced Heart Rate Increase by Partial Adenosine A1 Agonism

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    The release of the neurotransmitter norepinephrine (NE) is modulated by presynaptic adenosine receptors. In the present study we investigated the effect of a partial activation of this feedback mechanism. We hypothesized that partial agonism would have differential effects on NE release in isolated hearts as well as on heart rate in vivo depending on the genetic background and baseline sympathetic activity. In isolated perfused hearts of Wistar and Spontaneously Hypertensive Rats (SHR), NE release was induced by electrical stimulation under control conditions (S1), and with capadenoson 6 · 10−8 M (30 µg/l), 6 · 10−7 M (300 µg/l) or 2-chloro-N6-cyclopentyladenosine (CCPA) 10−6 M (S2). Under control conditions (S1), NE release was significantly higher in SHR hearts compared to Wistar (766+/−87 pmol/g vs. 173+/−18 pmol/g, p<0.01). Capadenoson led to a concentration-dependent decrease of the stimulation–induced NE release in SHR (S2/S1 = 0.90±0.08 with capadenoson 6 · 10−8 M, 0.54±0.02 with 6 · 10−7 M), but not in Wistar hearts (S2/S1 = 1.05±0.12 with 6 · 10−8 M, 1.03±0.09 with 6 · 10−7 M). CCPA reduced NE release to a similar degree in hearts from both strains. In vivo capadenoson did not alter resting heart rate in Wistar rats or SHR. Restraint stress induced a significantly greater increase of heart rate in SHR than in Wistar rats. Capadenoson blunted this stress-induced tachycardia by 45% in SHR, but not in Wistar rats. Using a [35S]GTPγS assay we demonstrated that capadenoson is a partial agonist compared to the full agonist CCPA (74+/−2% A1-receptor stimulation). These results suggest that partial adenosine A1-agonism dampens stress-induced tachycardia selectively in rats susceptible to strong increases in sympathetic activity, most likely due to a presynaptic attenuation of NE release

    Oral Contraceptives, Pregnancy, and the Veins

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