3-[(E)-2-(5,7-Dichloro-8-hydroxy­quinolin-2-yl)vin­yl]-4-hydroxy­phenyl acetate

The two symmetry independent mol­ecules of the title compound, C19H13Cl2NO4, show similar conformations with the acetyl group twisted strongly relative to the remaining, virtually flat (r.m.s. deviations = 0.0173 and 0.0065 Å), part of the mol­ecule. The hydroxyl groups of the 8-hydroxy­quinoline residues are involved in intra­molecular O—H⋯N hydrogen bonds, which, in one case, forms a part of a three-center inter­action. Inter­molecular O—H⋯O hydrogen bonds assemble the mol­ecules into a one-dimensional polymeric structure extended along the a axis. The 4-hydroxy­phenyl group of one mol­ecule forms an O—H⋯O hydrogen bond, in which the hydroxyl H atom is disordered, with its inversion center counterpart

2-(4-Methyl­phen­yl)-1-phenyl­sulfonyl-3-nitro-1,2-dihydro­quinoline

In the title compound, C22H18N2O4S, the dihedral angle between the phenyl­sulfonyl ring and the methyl­phenyl ring is 67.78 (7)°. In the crystal, mol­ecules are linked by weak inter­molecular C—H⋯O inter­actions into a zigzag chain along the [101] direction

دراسة تحليلية لواقع التهرب والتهريب في سورية وأثره على التنمية

تواجه جميع البلدان المتقدمة والمتخلفة مشكلة التهرب والتهريب ففي البعض منها مشكلة صغيرة وفي بعضها الآخر كبيرة, والحقيقة أن هذه المشكلة في سورية من الحجم الكبير, تؤثر سلباً على موارد الدولة وعلى الأداء الاقتصادي وعلى البنية الأخلاقية للمجتمع لذلك فإنّ مسألة التهرب والتهريب يجب أن تأخذ مكانها في برنامج الإصلاح الاقتصادي. إنّ الإصلاح الجيد يشترط أولاً الكشف عن المشكلة والتشهير بها بحيث يصعب الاستمرار في حمايتها وإخفائها ويشترط ثانياً التعرف العلمي الرقمي لواقع التهرب والتهريب, أشكالها وطرائقها وحجومها ومبالغها. وعند التعرف على حجم التهرب الضريبي في سورية والذي يتجاوز 200 مليار ل.س هذا يعني أن عمل الدولة وحرصها على استعادة هذه الأموال والقيام بتوظيفها واستثمارها سوف ينعكس على حياة الناس رفاهاً وازدهاراً, لما لهذه الظاهرة من ارتباط بالأمن الاقتصادي والنمو الاقتصادي وكافة الجوانب الاقتصادية والاجتماعية الأخرى

Inhibitors of Strand Transfer That Prevent Integration and Inhibit Human T-Cell Leukemia Virus Type 1 Early Replication▿

The replication of the retrovirus human T-cell leukemia virus type 1 (HTLV-1) is linked to the development of lymphoid malignancies and inflammatory diseases. Data from in vitro, ex vivo, and in vivo studies have revealed that no specific treatment can prevent or block HTLV-1 replication and therefore that there is no therapy for the prevention and/or treatment of HTLV-1-associated diseases in infected individuals. HTLV-1 and human immunodeficiency virus type 1 (HIV-1) integrases, the enzymes that specifically catalyze the integration of these retroviruses in host cell DNA, share important structural properties, suggesting that compounds that inhibit HIV-1 integration could also inhibit HTLV-1 integration. We developed quantitative assays to test, in vitro and ex vivo, the efficiencies of styrylquinolines and diketo acids, the two main classes of HIV-1 integrase inhibitors. The compounds were tested in vitro in an HTLV-1 strand-transfer reaction and ex vivo by infection of fresh peripheral blood lymphocytes with lethally irradiated HTLV-1-positive cells. In vitro, four styrylquinoline compounds and two diketo acid compounds significantly inhibited HTLV-1 integration in a dose-dependent manner. All compounds active in vitro decreased cell proliferation ex vivo, although at low concentrations; they also dramatically decreased both normalized proviral loads and the number of integration events during experimental ex vivo primary infection. Accordingly, diketo acids and styrylquinolines are the first drugs that produce a specific negative effect on HTLV-1 replication in vitro and ex vivo, suggesting their potential efficiency for the prevention and treatment of HTLV-1-associated diseases

7-arboxylato-8-hydroxy-2-methylquinolinium monohydrate and 7-carboxy-8-hydroxy-2-methylquinolinium chloride monohydrate at 100 K

International audienceBoth 7-carboxylato-8-hydroxy-2-methylquinolinium monohydrate, C11H9NO3.H2O, (1), and 7-carboxy-8-hydroxy-2-methylquinolinium chloride monohydrate, C11H10NO3+.Cl-.H2O, (11), crystallize in the centrosymmetric P (1) over bar space group. Both compounds display an intramolecular O-H ... O hydrogen bond involving the hydroxy group; this hydrogen bond is stronger in (1) due to its zwitterionic character [O ... O = 2.4449 (11) Angstrom in (1) and 2.5881 (12) Angstrom in (11)]. In both crystal structures, the HN+ group participates in the stabilization of the structure via intermolecular hydrogen bonds with water molecules [N ... O = 2.7450 (12) Angstrom in (1) and 2.8025 (14) Angstrom in (11)]. In compound (11), a hydrogen-bond network connects the Cl- anion to the carboxylic acid group [Cl ... O = 2.9641 (11) Angstrom] and to two water molecules [Cl ... O = 3.1485 (10) and 3.2744 (10) Angstrom